Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis (Q24304952)

Parkinson disease (autosomal recessive, early onset) 7

GOA release 2020-03-11

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GOA release 2020-03-11

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Ole P Ottersen

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Ted M. Dawson

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object named as

Ted M Dawson

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Darren J Moore

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object named as

Darren J Moore

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author name string

Li Zhang

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Mika Shimoji

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Bobby Thomas

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Seong-Woon Yu

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Neena I Marupudi

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Reidun Torp

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Ingeborg A Torgner

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Valina L Dawson

Mitochondria in the etiology and pathogenesis of parkinson's disease

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language of work or name

English

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publication date

15 July 2005

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published in

Human Molecular Genetics

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volume

14

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issue

14

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page(s)

2063-73

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cites work

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7 January 2021

DJ-1( PARK7), a novel gene for autosomal recessive, early onset parkinsonism

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Improved methods to isolate and subfractionate rat liver mitochondria. Lipid composition of the inner and outer membrane

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An electron microscopic study of MPTP-induced inclusion bodies in an old monkey

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Widespread expression of Huntington's disease gene (IT15) protein product

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Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition

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Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells

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Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

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Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1

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Mitochondrial involvement in Parkinson's disease

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Different modes of expression of AMPA and NMDA receptors in hippocampal synapses

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

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Targeting programmed cell death in neurodegenerative diseases

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DJ-1 has a role in antioxidative stress to prevent cell death

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Parkinson's disease. First of two parts

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Parkinson's disease. Second of two parts

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The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: A member of the DJ-1/ThiJ/PfpI superfamily

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7 January 2021

The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization

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7 January 2021

Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

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7 January 2021

The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early onset Parkinson's disease

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7 January 2021

L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system

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7 January 2021

Crystal structures of human DJ-1 and Escherichia coli Hsp31, which share an evolutionarily conserved domain

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7 January 2021

Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age.

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7 January 2021

Differential Effects of Parkinson's Disease-associated Mutations on Stability and Folding of DJ-1

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7 January 2021

Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function

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7 January 2021

Mitochondrial dysfunction and oxidative damage in parkin-deficient mice

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7 January 2021

Synapsin I (protein I), a nerve terminal-specific phosphoprotein. III. Its association with synaptic vesicles studied in a highly purified synaptic vesicle preparation

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7 January 2021

Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis

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7 January 2021

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

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7 January 2021

The DJ-1L166P mutant protein associated with early onset Parkinson's disease is unstable and forms higher-order protein complexes

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7 January 2021

Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress

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7 January 2021

A missense mutation (L166P) in DJ-1, linked to familial Parkinson's disease, confers reduced protein stability and impairs homo-oligomerization.

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7 January 2021

Mediation of poly(ADP-ribose) polymerase-1-dependent cell death by apoptosis-inducing factor

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7 January 2021

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

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7 January 2021

Molecular Pathways of Neurodegeneration in Parkinson's Disease

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alpha-Synuclein locus triplication causes Parkinson's disease

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Hereditary early-onset Parkinson's disease caused by mutations in PINK1

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

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Rare genetic mutations shed light on the pathogenesis of Parkinson disease

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7 January 2021

DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

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7 January 2021

Synuclein: a neuron-specific protein localized to the nucleus and presynaptic nerve terminal

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7 January 2021

Organization of AMPA receptor subunits at a glutamate synapse: a quantitative immunogold analysis of hair cell synapses in the rat organ of Corti

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7 January 2021

The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease.

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7 January 2021