ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance (Q24304398)

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Qingang Wu

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Taoling Zeng

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Qi Lin

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Yikai Qiao

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Qun Wang

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Mingdong Liu

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Xin Zhang

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Lan Ren

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Sheng Zhang

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Yihua Pei

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Zhenyu Yin

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Feng Ding

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Hong-Rui Wang

ATR: an essential regulator of genome integrity

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language of work or name

English

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publication date

2014

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published in

Nature Communications

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volume

5

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page(s)

4901

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cites work

1 reference

The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer

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Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

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Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription

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RETRACTED: p73alpha regulation by Chk1 in response to DNA damage

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Lats2 phosphorylates p21/CDKN1A after UV irradiation and regulates apoptosis.

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A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

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Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation

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Regulation of planar cell polarity by Smurf ubiquitin ligases

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Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

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Regulation of cell polarity and protrusion formation by targeting RhoA for degradation

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Ubiquitin ligase Smurf1 controls osteoblast activity and bone homeostasis by targeting MEKK2 for degradation

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E3 Ubiquitin Ligase Smurf1 Mediates Core-binding Factor α1/Runx2 Degradation and Plays A Specific Role in Osteoblast Differentiation

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Ubiquitination of tumor necrosis factor receptor-associated factor 4 (TRAF4) by Smad ubiquitination regulatory factor 1 (Smurf1) regulates motility of breast epithelial and cancer cells

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A Smurf1 tale: function and regulation of an ubiquitin ligase in multiple cellular networks

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Genome profiling of pancreatic adenocarcinoma

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CKIP-1 acts as a colonic tumor suppressor by repressing oncogenic Smurf1 synthesis and promoting Smurf1 autodegradation

21 January 2018

1 reference

Identification of SMURF1 as a possible target for 7q21.3-22.1 amplification detected in a pancreatic cancer cell line by in-house array-based comparative genomic hybridization.

21 January 2018

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SMURF1 plays a role in EGF-induced breast cancer cell migration and invasion.

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SMURF1 amplification promotes invasiveness in pancreatic cancer

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Smurf2 induces ubiquitin-dependent degradation of Smurf1 to prevent migration of breast cancer cells

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Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility

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Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.

21 January 2018

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Rho GTPases in cell biology

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GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

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Rho GTPases: biochemistry and biology

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Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility

21 January 2018

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Loss of RhoB expression in human lung cancer progression.

21 January 2018

1 reference

A distinct role of RhoB in gastric cancer suppression

21 January 2018

1 reference

Expression loss and revivification of RhoB gene in ovary carcinoma carcinogenesis and development

21 January 2018

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In vivo restoration of RhoB expression leads to ovarian tumor regression.

21 January 2018

1 reference

NSC126188, a piperazine alkyl derivative, induces apoptosis via upregulation of RhoB in HeLa cells.

21 January 2018

1 reference

RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells

21 January 2018

1 reference

RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage

21 January 2018

1 reference

NSC126188 induces apoptosis of prostate cancer PC-3 cells through inhibition of Akt membrane translocation, FoxO3a activation, and RhoB transcription

21 January 2018

1 reference

Upregulation of RhoB via c-Jun N-terminal kinase signaling induces apoptosis of the human gastric carcinoma NUGC-3 cells treated with NSC12618.

21 January 2018

1 reference

miR-21 targets the tumor suppressor RhoB and regulates proliferation, invasion and apoptosis in colorectal cancer cells

21 January 2018

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RhoB induces apoptosis via direct interaction with TNFAIP1 in HeLa cells

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Actin' up: RhoB in cancer and apoptosis

21 January 2018

1 reference

Binding of RhoA by the C2 domain of E3 ligase Smurf1 is essential for Smurf1-regulated RhoA ubiquitination and cell protrusive activity

21 January 2018

1 reference

Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signaling

21 January 2018

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PKA/Smurf1 signaling-mediated stabilization of Nur77 is required for anticancer drug cisplatin-induced apoptosis

21 January 2018

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21 January 2018

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Pivotal role of the C2 domain of the Smurf1 ubiquitin ligase in substrate selection

21 January 2018

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Checkpoint kinase 1 in DNA damage response and cell cycle regulation

21 January 2018

1 reference

The C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathway

21 January 2018

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21 January 2018

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RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation

21 January 2018

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Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.

21 January 2018

1 reference

Apoptosis and cancer: the genesis of a research field

21 January 2018

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Genome-wide array-based comparative genomic hybridization analysis of pancreatic adenocarcinoma: identification of genetic indicators that predict patient outcome

21 January 2018

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Degradation of RhoA by Smurf1 ubiquitin ligase

21 January 2018

1 reference

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

21 January 2018

1 reference

7 January 2021

The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis

1 reference

7 January 2021

Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice

1 reference

7 January 2021

The activation of p38 MAPK primarily contributes to UV-induced RhoB expression by recruiting the c-Jun and p300 to the distal CCAAT box of the RhoB promoter

1 reference

7 January 2021