Pim-2 phosphorylation of p21(Cip1/WAF1) enhances its stability and inhibits cell proliferation in HCT116 cells (Q24304170)

GOA release 2020-03-11

protein stabilization

1 reference

GOA release 2020-03-11

1 reference

Zeping Wang

1

0 references

Yandong Zhang

2

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Juan Jenny Gu

3

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Christine Davitt

4

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Raymond Reeves

5

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Nancy S Magnuson

International Journal of Biochemistry & Cell Biology

6

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language of work or name

English

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publication date

June 2010

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published in

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volume

42

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issue

6

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page(s)

1030-8

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cites work

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Pim-2 upregulation: biological implications associated with disease progression and perinueral invasion in prostate cancer

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Lost in transcription: p21 repression, mechanisms, and consequences

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Lymphocyte transformation by Pim-2 is dependent on nuclear factor-kappaB activation

19 March 2017

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The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death

19 March 2017

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The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor

19 March 2017

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Evidence for the involvement of pim-2, a new common proviral insertion site, in progression of lymphomas

19 March 2017

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PIM-2 is an independent regulator of chondrocyte survival and autophagy in the epiphyseal growth plate

19 March 2017

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Pim serine/threonine kinases regulate the stability of Socs-1 protein

19 March 2017

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Delineation of prognostic biomarkers in prostate cancer

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The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

7 April 2017

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Multiple roles of the cell cycle inhibitor p21(CDKN1A) in the DNA damage response.

7 April 2017

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A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma

27 September 2017

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Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis-inducing ability

27 September 2017

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Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as potent, highly selective, and orally bioavailable inhibitors of the human protooncogene proviral insertion site in moloney murine leukemia virus (PIM) kinases

27 September 2017

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Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

27 September 2017

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Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells

27 September 2017

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p21(WAF1/CIP1) and cancer: a shifting paradigm?

27 September 2017

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p21 in cancer: intricate networks and multiple activities

27 September 2017

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P21 and p27: roles in carcinogenesis and drug resistance

27 September 2017

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Pim-1 kinase-dependent phosphorylation of p21Cip1/WAF1 regulates its stability and cellular localization in H1299 cells

27 September 2017

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The intricacies of p21 phosphorylation: protein/protein interactions, subcellular localization and stability

27 September 2017

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Cytoplasmic p21WAF1/CIP1 correlates with Akt activation and poor response to tamoxifen in breast cancer.

27 September 2017

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The survival kinases Akt and Pim as potential pharmacological targets

27 September 2017

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The Pim kinases control rapamycin-resistant T cell survival and activation

27 September 2017

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Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients.

27 September 2017

1 reference

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New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?

27 September 2017

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The role of the cyclin-dependent kinase inhibitor p21 in apoptosis.

27 September 2017

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Pim-1: a serine/threonine kinase with a role in cell survival, proliferation, differentiation and tumorigenesis.

27 September 2017

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A molecular compendium of genes expressed in multiple myeloma

27 September 2017

1 reference

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AKT/PKB phosphorylation of p21Cip/WAF1 enhances protein stability of p21Cip/WAF1 and promotes cell survival

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862799

Akt-dependent phosphorylation of p21(Cip1) regulates PCNA binding and proliferation of endothelial cells

27 September 2017

1 reference

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Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells

27 September 2017

1 reference

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p21(WAF1/Cip1): more than a break to the cell cycle?

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862799

Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination

27 September 2017

1 reference

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Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862799

In vivo analysis of Pim-1 deficiency

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862799

Proviral tagging in E mu-myc transgenic mice lacking the Pim-1 proto-oncogene leads to compensatory activation of Pim-2.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862799

Inhibition of cyclin-dependent kinases by p21

27 September 2017

1 reference

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p21--negative regulator of the cell cycle

27 September 2017

1 reference

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Complementation tagging of cooperating oncogenes in knockout mice

27 September 2017

1 reference

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p21(Waf1/Cip1/Sdi1) mediates shear stress-dependent antiapoptotic function

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862799

Cytoplasmic p21Cip1 Is Involved in Ras-induced Inhibition of the ROCK/LIMK/Cofilin Pathway

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2862799

Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc

30 May 2018

1 reference

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Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

30 May 2018

1 reference

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Pim-1 and Pim-2 kinases are required for efficient pre-B-cell transformation by v-Abl oncogene

30 May 2018

1 reference

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Pim kinase substrate identification and specificity

29 November 2018

1 reference

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Molecular determinants of Akt-induced keratinocyte transformation

29 November 2018

1 reference

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The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation

29 November 2018

1 reference

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PKCeta associates with cyclin E/cdk2/p21 complex, phosphorylates p21 and inhibits cdk2 kinase in keratinocytes.

29 November 2018

1 reference

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29 November 2018

1 reference

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29 November 2018

1 reference

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Transcriptional Regulation of the p21(WAF1/CIP1)Gene

29 November 2018

1 reference

12 December 2020

The conflicting roles of the cdk inhibitor p21(CIP1/WAF1) in apoptosis

1 reference

12 December 2020

Identification of heterologous translocation partner genes fused to the BCL6 gene in diffuse large B-cell lymphomas: 5'-RACE and LA - PCR analyses of biopsy samples

1 reference

12 December 2020

Procaspase 3/p21 complex formation to resist fas-mediated cell death is initiated as a result of the phosphorylation of p21 by protein kinase A

1 reference

12 December 2020