Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2/3 complex and enhances actin polymerization by WASP (Q24302943)

identical protein binding

GOA release 2020-03-11

1 reference

Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein

GOA release 2020-03-11

Rainer Cramer

2

0 references

Anne Ridley

object named as

Anne J Ridley

series ordinal

4

0 references

Laurent Blanchoin

series ordinal

3

object named as

Laurent Blanchoin

0 references

author name string

Giles O C Cory

series ordinal

1

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language of work or name

English

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publication date

May 2003

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published in

Molecular Cell

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volume

11

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issue

5

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page(s)

1229-39

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cites work

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The Arp2/3 complex nucleates actin filament branches from the sides of pre-existing filaments

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Direct observation of dendritic actin filament networks nucleated by Arp2/3 complex and WASP/Scar proteins.

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Inducible recruitment of Cdc42 or WASP to a cell-surface receptor triggers actin polymerization and filopodium formation

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Role of accurate mass measurement ( /- 10 ppm) in protein identification strategies employing MS or MS/MS and database searching.

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Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein

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Analysis of phospho- and glycopolypeptides with infrared matrix-assisted laser desorption and ionization

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

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Arp2/3 complex requires hydrolyzable ATP for nucleation of new actin filaments

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Activation of the CDC42 effector N-WASP by the Shigella flexneri IcsA protein promotes actin nucleation by Arp2/3 complex and bacterial actin-based motility

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A novel neural Wiskott-Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2/3 complex activation independent of Cdc42

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Evaluation of two-dimensional differential gel electrophoresis for proteomic expression analysis of a model breast cancer cell system

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Activation by Cdc42 and PIP(2) of Wiskott-Aldrich syndrome protein (WASp) stimulates actin nucleation by Arp2/3 complex

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Influence of the C terminus of Wiskott-Aldrich syndrome protein (WASp) and the Arp2/3 complex on actin polymerization

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7 January 2021

The verprolin-like central (vc) region of Wiskott-Aldrich syndrome protein induces Arp2/3 complex-dependent actin nucleation.

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Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein

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7 January 2021

CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles

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7 January 2021

Requirement for Rho GTPases and PI 3-kinases during apoptotic cell phagocytosis by macrophages

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Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages

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Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex

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7 January 2021

Interaction of WASP/Scar proteins with actin and vertebrate Arp2/3 complex

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7 January 2021

WIP regulates N-WASP-mediated actin polymerization and filopodium formation

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Phosphorylation of WAVE downstream of mitogen-activated protein kinase signaling

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7 January 2021

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

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7 January 2021

The interaction of Arp2/3 complex with actin: nucleation, high affinity pointed end capping, and formation of branching networks of filaments

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7 January 2021

Protein kinase CK2: a challenge to canons

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7 January 2021

Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex

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The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly

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Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate

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7 January 2021

Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway

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7 January 2021

Identification of another actin-related protein (Arp) 2/3 complex binding site in neural Wiskott-Aldrich syndrome protein (N-WASP) that complements actin polymerization induced by the Arp2/3 complex activating (VCA) domain of N-WASP.

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7 January 2021

Requirement of the basic region of N-WASP/WAVE2 for actin-based motility.

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7 January 2021

Sustained activation of N-WASP through phosphorylation is essential for neurite extension

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7 January 2021

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

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7 January 2021

The Wiskott-Aldrich syndrome protein directs actin-based motility by stimulating actin nucleation with the Arp2/3 complex

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7 January 2021

Motility determinants in WASP family proteins

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7 January 2021

Activation of the Arp2/3 complex by the Listeria acta protein. Acta binds two actin monomers and three subunits of the Arp2/3 complex.

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7 January 2021

Different WASP family proteins stimulate different Arp2/3 complex-dependent actin-nucleating activities

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7 January 2021