Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action (Q24302566)

Regulatory associated protein of MTOR complex 1

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mechanistic target of rapamycin kinase

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Eukaryotic translation initiation factor 4E binding protein 1

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positive regulation of protein serine/threonine kinase activity

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Mechanistic target of rapamycin kinase

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Target of rapamycin homolog CELE_B0261.2

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1

Kenta Hara

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author name string

Yoshiko Maruki

2

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Xiaomeng Long

3

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Ken-ichi Yoshino

4

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Noriko Oshiro

5

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Sujuti Hidayat

6

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Chiharu Tokunaga

7

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Joseph Avruch

8

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Kazuyoshi Yonezawa

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

9

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language of work or name

English

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publication date

26 July 2002

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published in

Cell

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volume

110

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issue

2

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page(s)

177-89

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cites work

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

The p70 S6 kinase integrates nutrient and growth signals to control translational capacity.

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

TOR controls translation initiation and early G1 progression in yeast

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Control of p70 s6 kinase by kinase activity of FRAP in vivo

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Alpha 4 associates with protein phosphatases 2A, 4, and 6

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Amino acids stimulate phosphorylation of p70S6k and organization of rat adipocytes into multicellular clusters

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Functional genomic analysis of C. elegans chromosome I by systematic RNA interference

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Regulation of eIF-4E BP1 phosphorylation by mTOR.

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Cloning and characterization of a nuclear S6 kinase, S6 kinase-related kinase (SRK); a novel nuclear target of Akt

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

PHAS/4E-BPs as regulators of mRNA translation and cell proliferation

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Characterization of S6K2, a novel kinase homologous to S6K1

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

TOR deficiency in C. elegans causes developmental arrest and intestinal atrophy by inhibition of mRNA translation

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Mammalian target of rapamycin-dependent phosphorylation of PHAS-I in four (S/T)P sites detected by phospho-specific antibodies

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

B cell receptor-associated protein alpha4 displays rapamycin-sensitive binding directly to the catalytic subunit of protein phosphatase 2A

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Characterization of the phosphoproteins and protein kinase activity in mTOR immunoprecipitates.

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Bidirectional modulation of insulin action by amino acids

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

TOR, a central controller of cell growth

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cells

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

The WD repeat: a common architecture for diverse functions

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Carboxyl-terminal region conserved among phosphoinositide-kinase-related kinases is indispensable for mTOR function in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Specific interference by ingested dsRNA

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Amino acid availability regulates p70 S6 kinase and multiple translation factors

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

The fission yeast TOR homolog, tor1 , is required for the response to starvation and other stresses via a conserved serine

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic beta-cells. A possible role in protein translation and mitogenic signaling

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

1 reference

https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

Regulation of cellular growth by the Drosophila target of rapamycin dTOR

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https://api.crossref.org/works/10.1016/S0092-8674(02)00833-4

7 January 2021

10.1016/S0092-8674(02)00833-4

Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

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Consolidated OpenCitations Corpus – April 2017

PubMed publication ID

12150926

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Consolidated OpenCitations Corpus – April 2017