Evidence for the slow reaction of hypoxia-inducible factor prolyl hydroxylase 2 with oxygen (Q24299724)

6

0 references

Refaat B. Hamed

Refaat B Hamed

3

0 references

Emily Flashman

Emily Flashman

1

0 references

Carsten Krebs

Carsten Krebs

5

0 references

J. Martin Bollinger Jr.

4

J Martin Bollinger

0 references

author name string

Lee M Hoffart

Studies on the activity of the hypoxia-inducible-factor hydroxylases using an oxygen consumption assay

2

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language of work or name

English

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publication date

October 2010

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published in

FEBS Journal

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volume

277

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issue

19

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page(s)

4089-99

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cites work

1 reference

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HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1alpha in normoxia

19 March 2017

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FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

19 March 2017

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A conserved family of prolyl-4-hydroxylases that modify HIF

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C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

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Structural basis for binding of hypoxia-inducible factor to the oxygen-sensing prolyl hydroxylases

19 March 2017

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Crystal structure of a clavaminate synthase-Fe(II)-2-oxoglutarate-substrate-NO complex: evidence for metal centered rearrangements

19 March 2017

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19 March 2017

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Structure of a cephalosporin synthase

19 March 2017

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

19 March 2017

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Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor

19 March 2017

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Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

19 March 2017

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Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

19 March 2017

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Hypoxia-inducible factor prolyl hydroxylase 2 has a high affinity for ferrous iron and 2-oxoglutarate

19 March 2017

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Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases

19 March 2017

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Hydroxylation of HIF-1: oxygen sensing at the molecular level

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FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes

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Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells

19 March 2017

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Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

19 March 2017

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Characterization and comparative analysis of the EGLN gene family

19 March 2017

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The Expression and Distribution of the Hypoxia-Inducible Factors HIF-1α and HIF-2α in Normal Human Tissues, Cancers, and Tumor-Associated Macrophages

19 March 2017

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19 March 2017

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Purification and characterization of hypoxia-inducible factor 1

27 September 2017

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

19 March 2017

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Oxygen sensing by HIF hydroxylases

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Investigating the dependence of the hypoxia-inducible factor hydroxylases (factor inhibiting HIF and prolyl hydroxylase domain 2) on ascorbate and other reducing agents

7 April 2017

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Using NMR solvent water relaxation to investigate metalloenzyme-ligand binding interactions

27 September 2017

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Substrate positioning controls the partition between halogenation and hydroxylation in the aliphatic halogenase, SyrB2.

27 September 2017

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Substrate-triggered formation and remarkable stability of the C-H bond-cleaving chloroferryl intermediate in the aliphatic halogenase, SyrB2

27 September 2017

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Kinetic characterization and identification of a novel inhibitor of hypoxia-inducible factor prolyl hydroxylase 2 using a time-resolved fluorescence resonance energy transfer-based assay technology

27 September 2017

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The human oxygen sensing machinery and its manipulation

27 September 2017

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Kinetic rationale for selectivity toward N- and C-terminal oxygen-dependent degradation domain substrates mediated by a loop region of hypoxia-inducible factor prolyl hydroxylases

27 September 2017

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Direct spectroscopic evidence for a high-spin Fe(IV) intermediate in tyrosine hydroxylase

27 September 2017

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Non-heme Fe(IV)-oxo intermediates

27 September 2017

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Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase

27 September 2017

1 reference

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The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases

27 September 2017

1 reference

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Stalking intermediates in oxygen activation by iron enzymes: motivation and method

27 September 2017

1 reference

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Structural studies on 2-oxoglutarate oxygenases and related double-stranded beta-helix fold proteins

27 September 2017

1 reference

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Signalling hypoxia by HIF hydroxylases

27 September 2017

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The 2-His-1-carboxylate facial triad: a versatile platform for dioxygen activation by mononuclear non-heme iron(II) enzymes.

27 September 2017

1 reference

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Determination and comparison of specific activity of the HIF-prolyl hydroxylases

27 September 2017

1 reference

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Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates

27 September 2017

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Geometric and electronic structure/function correlations in non-heme iron enzymes

27 September 2017

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Dynamic states of the DNA repair enzyme AlkB regulate product release

27 September 2017

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CD and MCD of CytC3 and taurine dioxygenase: role of the facial triad in alpha-KG-dependent oxygenases

30 May 2018

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Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system

30 May 2018

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A stereochemical concept for the catalytic mechanism of prolylhydroxylase: applicability to classification and design of inhibitors.

30 May 2018

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Incorporation of oxygen into the succinate co-product of iron(II) and 2-oxoglutarate dependent oxygenases from bacteria, plants and humans

21 January 2018

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The first direct characterization of a high-valent iron intermediate in the reaction of an alpha-ketoglutarate-dependent dioxygenase: a high-spin FeIV complex in taurine/alpha-ketoglutarate dioxygenase (TauD) from Escherichia coli

21 January 2018

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Evidence for hydrogen abstraction from C1 of taurine by the high-spin Fe(IV) intermediate detected during oxygen activation by taurine:alpha-ketoglutarate dioxygenase (TauD).

21 January 2018

1 reference

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Kinetic dissection of the catalytic mechanism of taurine:alpha-ketoglutarate dioxygenase (TauD) from Escherichia coli

21 January 2018

1 reference

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Steady-state and transient kinetic analyses of taurine/alpha-ketoglutarate dioxygenase: effects of oxygen concentration, alternative sulfonates, and active-site variants on the FeIV-oxo intermediate

21 January 2018

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Rapid freeze-quench 57Fe Mössbauer spectroscopy: monitoring changes of an iron-containing active site during a biochemical reaction

21 January 2018

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Mechanism of Taurine: α-Ketoglutarate Dioxygenase (TauD) fromEscherichia coli

21 January 2018

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Stopped-Flow Kinetic Analysis ofEscherichia coliTaurine/α-Ketoglutarate Dioxygenase: Interactions with α-Ketoglutarate, Taurine, and Oxygen†

21 January 2018

1 reference

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Two interconverting Fe(IV) intermediates in aliphatic chlorination by the halogenase CytC3

21 January 2018

1 reference

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One motif--many different reactions

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20840591

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1742-4658.2010.07804.X

1 reference

1 reference

1 reference

PubMed publication ID

20840591

1 reference