Naturally Occurring Variants of Human Aldo-Keto Reductases with Reduced In Vitro Metabolism of Daunorubicin and Doxorubicin (Q24299666)

DOI

10.1124/JPET.110.173179

https://api.crossref.org/works/10.1124/JPET.110.173179

daunorubicin metabolic process

12 July 2024

main subject

1 reference

Gene Ontology release 2020-05-02

Gene Ontology ID

GO:0044597

Aldo-keto reductase family 1 member B

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aldo-keto reductase family 1 member B10

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Aldo-keto reductase family 1 member C1

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Aldo-keto reductase family 7 member A2

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Carbonyl reductase 4

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aldo-keto reductase family 1 member C2

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Aldo-keto reductase family 1 member C4

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aldo-keto reductase family 1 member C3

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doxorubicin metabolic process

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1 reference

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Onkar S. Bains

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:20837989

12 July 2024

Thomas A. Grigliatti

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:20837989

12 July 2024

Ronald E. Reid

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:20837989

12 July 2024

K. Wayne Riggs

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:20837989

12 July 2024

language of work or name

English

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publication date

December 2010

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13 September 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:20837989

full work available at URL

12 July 2024

http://intl-jpet.aspetjournals.org/cgi/content/abstract/335/3/533

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:20837989

https://syndication.highwire.org/content/doi/10.1124/jpet.110.173179

12 July 2024

1 reference

DOI

10.1124/JPET.110.173179

https://api.crossref.org/works/10.1124/JPET.110.173179

Journal of Pharmacology and Experimental Therapeutics

12 July 2024

published in

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volume

335

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issue

3

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page(s)

533-45

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cites work

Genetic polymorphisms in the carbonyl reductase 3 gene CBR3 and the NAD(P)H:quinone oxidoreductase 1 gene NQO1 in patients who developed anthracycline-related congestive heart failure after childhood cancer

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An introduction to the metabolic determinants of anthracycline cardiotoxicity.

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Anthracycline cardiotoxicity in breast cancer patients: synergism with trastuzumab and taxanes

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Role of anthracyclines in the era of targeted therapy

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Genotyping the risk of anthracycline-induced cardiotoxicity

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Reduction of drug ketones by dihydrodiol dehydrogenases, carbonyl reductase and aldehyde reductase of human liver

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7 January 2021

The molecular pharmacology of doxorubicin in vivo

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Human aldo-keto reductases: Function, gene regulation, and single nucleotide polymorphisms

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7 January 2021

Human carbonyl reductase 4 is a mitochondrial NADPH-dependent quinone reductase

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7 January 2021

An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target for the treatment of hormone dependent and hormone

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7 January 2021

Increased resistance of tumor cells to daunorubicin after transfection of cDNAs coding for anthracycline inactivating enzymes.

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7 January 2021

Aldo-keto reductases in which the conserved catalytic histidine is substituted

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7 January 2021

A new nomenclature for the aldo-keto reductase superfamily

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7 January 2021

Crystal structure of human prostaglandin F synthase (AKR1C3)

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7 January 2021

Expression and characterization of four recombinant human dihydrodiol dehydrogenase isoforms: oxidation of trans-7, 8-dihydroxy-7,8-dihydrobenzo[a]pyrene to the activated o-quinone metabolite benzo[a]pyrene-7,8-dione

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7 January 2021

Retention of NADPH-linked quinone reductase activity in an aldo-keto reductase following mutation of the catalytic tyrosine

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https://api.crossref.org/works/10.1124/JPET.110.173179

7 January 2021

Daunorubicin continuous infusion induces more toxicity than bolus infusion in acute lymphoblastic leukemia induction regimen: a randomized study

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7 January 2021

Identification of a novel NADH-specific aldo-keto reductase using sequence and structural homologies.

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7 January 2021

Roles of the C-terminal domains of human dihydrodiol dehydrogenase isoforms in the binding of substrates and modulators: probing with chimaeric enzymes

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7 January 2021

Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members

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Carbonyl reductases and pluripotent hydroxysteroid dehydrogenases of the short-chain dehydrogenase/reductase superfamily

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The aldo-keto reductase superfamily and its role in drug metabolism and detoxification

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7 January 2021

The use of liposomal daunorubicin (DaunoXome) in acute myeloid leukemia

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Characterization of a novel variant (S145C/L311V) of 3 ??-hydroxysteroid/dihydrodiol dehydrogenase in human liver

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7 January 2021

Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3)

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7 January 2021

Purification and characterization of akr1b10 from human liver: role in carbonyl reduction of xenobiotics

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7 January 2021

Two allelic variants of aldo-keto reductase 1A1 exhibit reduced in vitro metabolism of daunorubicin

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7 January 2021

Aldo-keto reductase 1C2 fails to metabolize doxorubicin and daunorubicin in vitro

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7 January 2021

Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver

1 reference

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7 January 2021

Two nonsynonymous single nucleotide polymorphisms of human carbonyl reductase 1 demonstrate reduced in vitro metabolism of daunorubicin and doxorubicin

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7 January 2021

Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism

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7 January 2021

Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology

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7 January 2021

Aldo-keto reductases and bioactivation/detoxication.

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7 January 2021

Cardiotoxicity of Cancer Therapy

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7 January 2021

Anthracycline-induced cardiotoxicity: course, pathophysiology, prevention and management

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7 January 2021

Multiplicity of mammalian reductases for xenobiotic carbonyl compounds

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7 January 2021

Pharmacokinetic-pharmacodynamic relationships of the anthracycline anticancer drugs.

1 reference

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7 January 2021

Identifiers

DOI

10.1124/JPET.110.173179

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017

1 reference

Consolidated OpenCitations Corpus – April 2017