PML/RARalpha targets promoter regions containing PU.1 consensus and RARE half sites in acute promyelocytic leukemia (Q24299511)

2

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Jiantao Shi

3

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Xuehua Zhu

4

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Miaomiao He

5

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Xiaohong Jia

6

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Xianwen Yang

7

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Fei Qiu

8

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Wen Jin

9

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Maoxiang Qian

10

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Hai Fang

11

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Jianqing Mi

12

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Xuzhi Yang

13

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Huasheng Xiao

14

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Mark Minden

15

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Yanzhi Du

16

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Zhu Chen

17

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Ji Zhang

PMLRAR homodimers: distinct DNA binding properties and heteromeric interactions with RXR

18

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language of work or name

English

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publication date

17 February 2010

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published in

Cancer Cell

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volume

17

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issue

2

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page(s)

186-97

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RXR is an essential component of the oncogenic PML/RARA complex in vivo

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PML-RARA-RXR oligomers mediate retinoid and rexinoid/cAMP cross-talk in acute promyelocytic leukemia cell differentiation

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PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis

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ATRA resolves the differentiation block in t(15;17) acute myeloid leukemia by restoring PU.1 expression

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