Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6 (Q24299331)

Bone morphogenetic protein 2

GOA release 2020-03-11

1 reference

negative regulation of osteoblast differentiation

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

Toru Ogasawara

1

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Hiroshi Kawaguchi

2

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Shigeki Jinno

3

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Kazuto Hoshi

4

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Keiji Itaka

5

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Tsuyoshi Takato

6

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Kozo Nakamura

7

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Hiroto Okayama

Molecular and Cellular Biology

8

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language of work or name

English

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publication date

August 2004

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published in

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volume

24

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issue

15

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page(s)

6560-8

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cites work

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A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

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CDK inhibitors: positive and negative regulators of G1-phase progression

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Cdk6-cyclin D3 complex evades inhibition by inhibitor proteins and uniquely controls cell's proliferation competence

19 March 2017

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Negative regulation of BMP/Smad signaling by Tob in osteoblasts

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Smad1 interacts with homeobox DNA-binding proteins in bone morphogenetic protein signaling

19 March 2017

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Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

19 March 2017

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G1 phase progression: cycling on cue

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

7 April 2017

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Runx2 is a common target of transforming growth factor beta1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12.

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A pcl-like cyclin activates the Res2p-Cdc10p cell cycle "start" transcriptional factor complex in fission yeast

27 September 2017

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Inhibition of E-selectin gene expression by transforming growth factor beta in endothelial cells involves coactivator integration of Smad and nuclear factor kappaB-mediated signals

27 September 2017

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SIP1, a novel zinc finger/homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes

27 September 2017

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Identification of a novel bone morphogenetic protein-responsive gene that may function as a noncoding RNA.

27 September 2017

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Role of morphogenetic proteins in skeletal tissue engineering and regeneration

27 September 2017

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SMADs: mediators and regulators of TGF-beta signaling

27 September 2017

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Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.

30 May 2018

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Overexpression of Cdk6-cyclin D3 highly sensitizes cells to physical and chemical transformation

30 May 2018

1 reference

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The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation

29 November 2018

1 reference

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Smad-mediated transcription is required for transforming growth factor-beta 1-induced p57(Kip2) proteolysis in osteoblastic cells

29 November 2018

1 reference

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Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith–Wiedemann syndrome

29 November 2018

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Tumor suppressor genes

1 reference

12 December 2020

p57(Kip2) is degraded through the proteasome in osteoblasts stimulated to proliferation by transforming growth factor beta1

1 reference

12 December 2020

Interaction and functional cooperation of NF-kappa B with Smads. Transcriptional regulation of the junB promoter

1 reference

12 December 2020

Regulation of bone formation and vision by LRP5

1 reference

12 December 2020