The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex (Q24299205)

protein serine/threonine kinase activity

GOA release 2020-03-11

1 reference

Journal of Clinical Investigation

GOA release 2020-03-11

author name string

Chao-Ling Yang

series ordinal

1

0 references

Xiaoman Zhu

series ordinal

2

0 references

David H Ellison

series ordinal

3

0 references

language of work or name

English

0 references

publication date

November 2007

0 references

published in

0 references

volume

117

0 references

issue

11

0 references

page(s)

3403-11

0 references

cites work

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WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis

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Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4

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The Na :Cl- cotransporter is activated and phosphorylated at the amino-terminal domain upon intracellular chloride depletion

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WNK4 regulates the balance between renal NaCl reabsorption and K secretion

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Regulation of WNK1 by an autoinhibitory domain and autophosphorylation

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WNK kinases, a novel protein kinase subfamily in multi-cellular organisms

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Human hypertension caused by mutations in WNK kinases

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WNK1 affects surface expression of the ROMK potassium channel independent of WNK4

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The WNK1 and WNK4 protein kinases that are mutated in Gordon's hypertension syndrome phosphorylate and activate SPAK and OSR1 protein kinases

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WNK kinases regulate thiazide-sensitive Na-Cl cotransport

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WNK protein kinases modulate cellular Cl- flux by altering the phosphorylation state of the Na-K-Cl and K-Cl cotransporters

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WNK1 kinase isoform switch regulates renal potassium excretion.

27 September 2017

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WNK3, a kinase related to genes mutated in hereditary hypertension with hyperkalaemia, regulates the K channel ROMK1 (Kir1.1).

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Mechanisms of WNK1 and WNK4 interaction in the regulation of thiazide-sensitive NaCl cotransport

27 September 2017

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Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells

27 September 2017

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Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells

27 September 2017

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Molecular physiology and pathophysiology of electroneutral cation-chloride cotransporters.

27 September 2017

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Role of WNK kinases in regulating tubular salt and potassium transport and in the development of hypertension

27 September 2017

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Sodium and potassium handling by the aldosterone-sensitive distal nephron: the pivotal role of the distal and connecting tubule

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045602

WNK kinases: molecular regulators of integrated epithelial ion transport

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045602

Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3).

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045602

Negative regulators of sodium transport in the kidney: key factors in understanding salt-sensitive hypertension?

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045602

Molecular mechanisms of human hypertension

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045602

Mammalian distal tubule: physiology, pathophysiology, and molecular anatomy

27 September 2017

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045602

Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045602

A new kindred with pseudohypoaldosteronism type II and a novel mutation (564D>H) in the acidic motif of the WNK4 gene

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045602

Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density

29 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2045602

A molecular switch controlling renal sodium and potassium excretion

29 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17975670

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Wnk4 controls blood pressure and potassium homeostasis via regulation of mass and activity of the distal convoluted tubule

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17975670

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/ ) knockin mouse model

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17975670