Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling (Q24298930)

1

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Xuchu Li

2

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Michael T Henzl

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Lesa J Beamer

4

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Mark Hannink

Gigaxonin interacts with tubulin folding cofactor B and controls its degradation through the ubiquitin-proteasome pathway

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language of work or name

English

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publication date

9 August 2006

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published in

The EMBO Journal

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volume

25

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issue

15

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page(s)

3605-17

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cites work

1 reference

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19 March 2017

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Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway

19 March 2017

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BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase

19 March 2017

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Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

19 March 2017

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

19 March 2017

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Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

19 March 2017

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19 March 2017

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19 March 2017

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

19 March 2017

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Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast

19 March 2017

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Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region

19 March 2017

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Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model

19 March 2017

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19 March 2017

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Crystal structure of the Kelch domain of human Keap1

19 March 2017

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19 March 2017

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Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron

19 March 2017

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Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase

19 March 2017

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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

19 March 2017

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The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm

19 March 2017

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Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription

19 March 2017

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Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene

19 March 2017

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Use of TLS parameters to model anisotropic displacements in macromolecular refinement

19 March 2017

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19 March 2017

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Oxidants, oxidative stress and the biology of ageing

22 April 2017

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The gene encoding gigaxonin, a new member of the cytoskeletal BTB/kelch repeat family, is mutated in giant axonal neuropathy

19 March 2017

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The finer things in X-ray diffraction data collection

19 March 2017

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19 March 2017

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Efficient anisotropic refinement of macromolecular structures using FFT

22 April 2017

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19 March 2017

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The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2

19 March 2017

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Main-chain bond lengths and bond angles in protein structures

19 March 2017

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Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer

19 March 2017

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Oxidative and electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1

7 April 2017

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The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase

7 April 2017

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Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers

7 April 2017

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

7 April 2017

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Pathways of Oxidative Damage

7 April 2017

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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

7 April 2017

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Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors

7 April 2017

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CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.

7 April 2017

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Nrf2 as a target for cancer chemoprevention

27 September 2017

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Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2

27 September 2017

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Specific patterns of electrophile adduction trigger Keap1 ubiquitination and Nrf2 activation

27 September 2017

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Nrf2 Possesses a redox-insensitive nuclear export signal overlapping with the leucine zipper motif.

27 September 2017

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27 September 2017

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Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane

21 January 2018

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Axis determination by inhibition of Wnt signaling in Xenopus

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A keaper and a striker maintain epidermal homeostasis

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Clinical and molecular findings in patients with giant axonal neuropathy (GAN)

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PubMed

https://pubmed.ncbi.nlm.nih.gov/16888629

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/SJ.EMBOJ.7601243

1 reference

1 reference

1 reference

PubMed publication ID

16888629

1 reference