Differential regulation of TGF-beta signaling through Smad2, Smad3 and Smad4 (Q24297637)

SMAD family member 2

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transforming growth factor beta 1

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positive regulation of transcription, DNA-templated

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author name string

Anny Kretschmer

1

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Kristin Moepert

2

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Sibylle Dames

3

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Maria Sternberger

4

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Joerg Kaufmann

5

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Anke Klippel

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

6

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language of work or name

English

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publication date

2 October 2003

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published in

Oncogene

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volume

22

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issue

43

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page(s)

6748-63

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cites work

1 reference

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Smads as transcriptional co-modulators

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Signal transduction by the TGF-beta superfamily

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Response of normal and oncogene-transformed human mammary epithelial cells to transforming growth factor beta 1 (TGF-beta 1): lack of growth-inhibitory effect on cells expressing the simian virus 40 large-T antigen

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Cell differentiation by extracellular matrix components.

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Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line

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The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

21 January 2018

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Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program

21 January 2018

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E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

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A role for transcriptional repression of p21CIP1 by c-Myc in overcoming transforming growth factor beta -induced cell-cycle arrest

21 January 2018

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Sedimentation studies reveal a direct role of phosphorylation in Smad3:Smad4 homo- and hetero-trimerization

21 January 2018

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Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction

21 January 2018

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Direct interaction of c-Myc with Smad2 and Smad3 to inhibit TGF-beta-mediated induction of the CDK inhibitor p15(Ink4B)

21 January 2018

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High-pressure liquid chromatography in polynucleotide synthesis

21 January 2018

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Progressive abrogation of TGF-beta 1 and EGF growth control is associated with tumour progression in ras-transfected human keratinocytes

21 January 2018

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The Hallmarks of Cancer

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Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-beta in cells lacking the CDK inhibitor p15

21 January 2018

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Stoichiometry of active smad-transcription factor complexes on DNA

21 January 2018

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Distinct oligomeric states of SMAD proteins in the transforming growth factor-beta pathway

21 January 2018

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The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity

21 January 2018

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Id2 is a retinoblastoma protein target and mediates signalling by Myc oncoproteins

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Down-regulation of Id-1 expression is associated with TGF beta 1-induced growth arrest in prostate epithelial cells

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How cells read TGF-beta signals

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Transcriptional control by the TGF-beta/Smad signaling system

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From mono- to oligo-Smads: the heart of the matter in TGF-beta signal transduction

21 January 2018

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TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

21 January 2018

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Epithelial to mesenchymal transition in Madin-Darby canine kidney cells is accompanied by down-regulation of Smad3 expression, leading to resistance to transforming growth factor-beta-induced growth arrest.

21 January 2018

1 reference

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Smad2 role in mesoderm formation, left-right patterning and craniofacial development

21 January 2018

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Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts

21 January 2018

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Transforming growth factor beta 1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation

21 January 2018

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Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control

21 January 2018

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TGF-beta signaling from receptors to the nucleus

21 January 2018

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Epidermal organization and differentiation of HaCaT keratinocytes in organotypic coculture with human dermal fibroblasts

21 January 2018

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TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

21 January 2018

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The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

21 January 2018

1 reference

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Targeted disruption in murine cells reveals variable requirement for Smad4 in transforming growth factor beta-related signaling.

21 January 2018

1 reference

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Repression of p15INK4b expression by Myc through association with Miz-1

21 January 2018

1 reference

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GeneBlocs are powerful tools to study and delineate signal transduction processes that regulate cell growth and transformation

21 January 2018

1 reference

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TGF-beta signaling: positive and negative effects on tumorigenesis

21 January 2018

1 reference

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Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo

21 January 2018

1 reference

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Myc downregulation by transforming growth factor beta required for activation of the p15(Ink4b) G(1) arrest pathway.

21 January 2018

1 reference

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Functions of mammalian Smad genes as revealed by targeted gene disruption in mice

21 January 2018

1 reference

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Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2.

21 January 2018

1 reference

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Suppression of keratin 15 expression by transforming growth factor beta in vitro and by cutaneous injury in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206791

Environmental-dependent acceleration of a developmental switch: the floral transition

21 January 2018

1 reference

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21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206791

Expression of TGF-beta signaling genes in the normal, premalignant, and malignant human trophoblast: loss of smad3 in choriocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206791

Reconstitution of Smad3 restores TGF-beta response of tissue inhibitor of metalloprotease-1 upregulation in human choriocarcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206791

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206791

Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta

21 January 2018

1 reference

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Regulation of Smad signalling by protein associations and signalling crosstalk

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206791

Negative effect of the transcriptional activator GAL4

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206791

Smithsonian closure plan under fire

21 January 2018

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206791

inferred from DOI database lookup

7 January 2021

based on heuristic

Smad7-dependent regulation of heme oxygenase-1 by transforming growth factor-beta in human renal epithelial cells

1 reference

https://api.crossref.org/works/10.1038/SJ.ONC.1206791