Peutz-Jeghers LKB1 mutants fail to activate GSK-3beta, preventing it from inhibiting Wnt signaling (Q24296680)

negative regulation of canonical Wnt signaling pathway

GOA release 2020-03-11

1 reference

Serine/threonine kinase 11

GOA release 2020-03-11

1 reference

Molecular Genetics and Genomics

GOA release 2020-03-11

author

Stilianos Antonarakis

series ordinal

3

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Christelle Borel

series ordinal

2

object named as

Christelle Borel

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author name string

Nathalie Lin-Marq

series ordinal

1

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language of work or name

English

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publication date

April 2005

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published in

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volume

273

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issue

2

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page(s)

184-96

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cites work

Correlation of Staining for LKB1 and COX-2 in Hamartomatous Polyps and Carcinomas from Patients with Peutz–Jeghers Syndrome

1 reference

Crossref

https://api.crossref.org/works/10.1007/S00438-005-1124-Y

Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

21 January 2018

1 reference

12 December 2020

Interaction of activator of G-protein signaling 3 (AGS3) with LKB1, a serine/threonine kinase involved in cell polarity and cell cycle progression: phosphorylation of the G-protein regulatory (GPR) motif as a regulatory mechanism for the interaction

1 reference

12 December 2020

GSK-3: tricks of the trade for a multi-tasking kinase

1 reference

12 December 2020

Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice

1 reference

12 December 2020

Caught up in a Wnt storm: Wnt signaling in cancer

1 reference

12 December 2020

Robust estimators for expression analysis

1 reference

12 December 2020

The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry

1 reference

12 December 2020

The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death

1 reference

12 December 2020

Mutations and impaired function of LKB1 in familial and non-familial Peutz-Jeghers syndrome and a sporadic testicular cancer.

1 reference

12 December 2020

Increased risk for cancer in patients with the Peutz-Jeghers syndrome

1 reference

12 December 2020

Regulation of GSK-3: a cellular multiprocessor

1 reference

12 December 2020

LKB1 tumor suppressor protein: PARtaker in cell polarity

1 reference

12 December 2020

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

1 reference

12 December 2020

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

1 reference

12 December 2020

1 reference

12 December 2020

Analysis of high density expression microarrays with signed-rank call algorithms

1 reference

12 December 2020

Molecular cloning and characterization of human podocalyxin-like protein. Orthologous relationship to rabbit PCLP1 and rat podocalyxin

1 reference

12 December 2020

Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow

1 reference

12 December 2020

Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex

1 reference

12 December 2020

Smooth muscle expresses bone morphogenetic protein (Vgr-1/BMP-6) in human fetal intestine

1 reference

12 December 2020

High-level transgene expression in human hematopoietic progenitors and differentiated blood lineages after transduction with improved lentiviral vectors

1 reference

12 December 2020

Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors.

1 reference

12 December 2020

Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients.

1 reference

12 December 2020

LKB1 (XEEK1) regulates Wnt signalling in vertebrate development

1 reference

12 December 2020

Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis

1 reference

12 December 2020

LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo

1 reference

12 December 2020

Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development

1 reference

12 December 2020

Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene

1 reference

12 December 2020

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

1 reference

12 December 2020

Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'-phosphate kinase/PTEN pathway.

1 reference

12 December 2020

Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity

1 reference

12 December 2020

Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

1 reference

12 December 2020

LKB1, a protein kinase regulating cell proliferation and polarity

1 reference

12 December 2020

Perinatal hypoxia-ischemia decreased neuronal but increased cerebral vascular endothelial IGFBP3 expression

1 reference

12 December 2020

Peutz-Jeghers syndrome is caused by mutations in a novel serine threoninekinase

1 reference

12 December 2020

Mechanism and function of signal transduction by the Wnt/beta-catenin and Wnt/Ca2 pathways

1 reference

12 December 2020

Analysis of SM22alpha-deficient mice reveals unanticipated insights into smooth muscle cell differentiation and function

1 reference

12 December 2020

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

1 reference

12 December 2020

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

1 reference

12 December 2020

Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome.

1 reference

12 December 2020

Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD

1 reference

12 December 2020

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

1 reference

12 December 2020

Elastic fiber homeostasis requires lysyl oxidase-like 1 protein

1 reference

12 December 2020

Immunolocalization of beta catenin in intestinal polyps of Peutz-Jeghers and juvenile polyposis syndromes

1 reference

12 December 2020

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

1 reference

12 December 2020

Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis

1 reference

12 December 2020

Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice

1 reference

12 December 2020

Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins

1 reference

12 December 2020

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

1 reference

12 December 2020

Growth suppression by Lkb1 is mediated by a G(1) cell cycle arrest

1 reference

12 December 2020

Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

1 reference

12 December 2020

LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest

1 reference

12 December 2020

Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1

1 reference

12 December 2020

Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis

1 reference

12 December 2020

A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity

1 reference

12 December 2020

Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

1 reference

12 December 2020

Cloning and characterization of a novel serine/threonine protein kinase expressed in early Xenopus embryos

1 reference

12 December 2020

Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways.

1 reference

12 December 2020

A serine/threonine kinase gene defective in Peutz-Jeghers syndrome

1 reference

12 December 2020

LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1

1 reference

12 December 2020

Cdc42 regulates GSK-3beta and adenomatous polyposis coli to control cell polarity

1 reference

12 December 2020

Causal relationship between the loss of RUNX3 expression and gastric cancer

1 reference

12 December 2020

Very high risk of cancer in familial Peutz-Jeghers syndrome

1 reference

12 December 2020

The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase

1 reference

12 December 2020

Reduction of Cell Surface Fibronectin (LETS Protein) Correlates with Tumorigenicity of Hamster Fibroblasts Transformed by Herpes Simplex Virus Type 2

1 reference

12 December 2020

LKB1--a master tumour suppressor of the small intestine and beyond

1 reference

12 December 2020

Smad4/DPC4-mediated tumor suppression through suppression of angiogenesis

1 reference

12 December 2020

Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366

1 reference

12 December 2020

Loss of cytoplasmic retention ability of mutant LKB1 found in Peutz-Jeghers syndrome patients

1 reference

12 December 2020