PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? (Q24296651)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17290298 AND SRC:MED&resulttype=core&format=json

25 December 2019

review article

1 reference

title

PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond? (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17290298 AND SRC:MED&resulttype=core&format=json

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

25 December 2019

main subject

inflammation

0 references

1 reference

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

innate immune response

1 reference

GOA release 2020-03-11

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17290298 AND SRC:MED&resulttype=core&format=json

25 December 2019

author name string

Christian Rommel

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17290298 AND SRC:MED&resulttype=core&format=json

25 December 2019

Hong Ji

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17290298 AND SRC:MED&resulttype=core&format=json

25 December 2019

language of work or name

English

0 references

publication date

9 February 2007

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17290298 AND SRC:MED&resulttype=core&format=json

Nature Reviews Immunology

25 December 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17290298 AND SRC:MED&resulttype=core&format=json

25 December 2019

volume

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17290298 AND SRC:MED&resulttype=core&format=json

25 December 2019

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17290298 AND SRC:MED&resulttype=core&format=json

25 December 2019

page(s)

191-201

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17290298 AND SRC:MED&resulttype=core&format=json

A new grammar for drug discovery

25 December 2019

cites work

1 reference

The phosphoinositide 3-kinase pathway

31 March 2020

1 reference

Synthesis and function of 3-phosphorylated inositol lipids

31 March 2020

1 reference

The phosphoinositide (PI) 3-kinase family

31 March 2020

1 reference

Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement

31 March 2020

1 reference

Phosphoinositide 3-kinase in immunological systems

31 March 2020

1 reference

The p85 regulatory subunit controls sequential activation of phosphoinositide 3-kinase by Tyr kinases and Ras.

31 March 2020

1 reference

Signalling by PI3K isoforms: insights from gene-targeted mice.

31 March 2020

1 reference

Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.

31 March 2020

1 reference

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

31 March 2020

1 reference

p84, a new Gbetagamma-activated regulatory subunit of the type IB phosphoinositide 3-kinase p110gamma

31 March 2020

1 reference

Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma

31 March 2020

1 reference

A novel phosphoinositide 3 kinase activity in myeloid-derived cells is activated by G protein beta gamma subunits

31 March 2020

1 reference

Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit.

31 March 2020

1 reference

PI3Kγ Modulates the Cardiac Response to Chronic Pressure Overload by Distinct Kinase-Dependent and -Independent Effects

31 March 2020

1 reference

Phosphoinositide 3-kinases as targets for therapeutic intervention

31 March 2020

1 reference

Phosphoinositide 3-kinase signalling--which way to target?

31 March 2020

1 reference

Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction

31 March 2020

1 reference

Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold

31 March 2020

1 reference

Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase.

31 March 2020

1 reference

A crucial role for the p110delta subunit of phosphatidylinositol 3-kinase in B cell development and activation

31 March 2020

1 reference

Essential, nonredundant role for the phosphoinositide 3-kinase p110delta in signaling by the B-cell receptor complex.

31 March 2020

1 reference

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha

31 March 2020

1 reference

Phosphoinositide 3-kinase controls early and late events in mammalian cell division

31 March 2020

1 reference

Positive and Negative Roles of p85α and p85β Regulatory Subunits of Phosphoinositide 3-Kinase in Insulin Signaling

31 March 2020

1 reference

Increased insulin sensitivity in mice lacking p85beta subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

31 March 2020

1 reference

Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation.

31 March 2020

1 reference

Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction

31 March 2020

1 reference

Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration

31 March 2020

1 reference

Defective dendritic cell migration and activation of adaptive immunity in PI3Kgamma-deficient mice

31 March 2020

1 reference

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

31 March 2020

1 reference

Phosphoinositide 3-kinase gamma is an essential amplifier of mast cell function

31 March 2020

1 reference

Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents.

31 March 2020

1 reference

PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

31 March 2020

1 reference

Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis.

31 March 2020

1 reference

Inhibiting inflammation in rheumatoid arthritis

31 March 2020

1 reference

Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases

31 March 2020

1 reference

Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model

31 March 2020

1 reference

Evolving concepts of rheumatoid arthritis

31 March 2020

1 reference

The T cell cometh: interplay between adaptive immunity and cytokine networks in rheumatoid arthritis

31 March 2020

1 reference

The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease

31 March 2020

1 reference

A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?

31 March 2020

1 reference

B cells in rheumatoid synovitis

31 March 2020

1 reference

Analysis of cytokine expression in rheumatoid synovium has provided new insights into the pathogenesis of rheumatoid arthritis and new therapeutic opportunities

31 March 2020

1 reference

Dendritic cells in rheumatoid arthritis

31 March 2020

1 reference

Mast cells in autoimmune disease

31 March 2020

1 reference

Mast cells: a cellular link between autoantibodies and inflammatory arthritis

31 March 2020

1 reference

Mast cells in inflammatory arthritis

31 March 2020

1 reference

Seeing the wood for the trees: the forgotten role of neutrophils in rheumatoid arthritis

31 March 2020

1 reference

Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis.

31 March 2020

1 reference

Genetics of rheumatoid arthritis: is there a scientific explanation for the human leukocyte antigen association?

31 March 2020

1 reference

Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis

31 March 2020

1 reference

The HLA-DRB1 locus as a genetic component in giant cell arteritis. Mapping of a disease-linked sequence motif to the antigen binding site of the HLA-DR molecule

31 March 2020

1 reference

CD4 CD7- CD28- T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity

31 March 2020

1 reference

Treatment of rheumatoid arthritis with the selective costimulation modulator abatacept: twelve-month results of a phase iib, double-blind, randomized, placebo-controlled trial

31 March 2020

1 reference

The evolving clinical profile of abatacept (CTLA4-Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis

31 March 2020

1 reference

Synovial tissue macrophage populations and articular damage in rheumatoid arthritis

31 March 2020

1 reference

Synovial tissue macrophages and joint erosion in rheumatoid arthritis

31 March 2020

1 reference

A new role for the p85-phosphatidylinositol 3-kinase regulatory subunit linking FRAP to p70 S6 kinase activation.

31 March 2020

1 reference

Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase

31 March 2020

1 reference

Phosphatidylinositol 3-kinase regulates the CD4/CD8 T cell differentiation ratio

31 March 2020

1 reference

Systemic lupus erythematosus and B-cell hematologic neoplasm

31 March 2020

1 reference

Impaired Fas response and autoimmunity in Pten /- mice

31 March 2020

1 reference

Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion

31 March 2020

1 reference

Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing

31 March 2020

1 reference

Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases

31 March 2020

1 reference

The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells

31 March 2020

1 reference

Cutting edge: the phosphoinositide 3-kinase p110 delta is critical for the function of CD4 CD25 Foxp3 regulatory T cells

31 March 2020

1 reference

Autoantibody specificities of immune complexes sequestered in articular cartilage of patients with rheumatoid arthritis and osteoarthritis

31 March 2020

1 reference

Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis

31 March 2020

1 reference

B-cell targeting in rheumatoid arthritis and other autoimmune diseases

31 March 2020

1 reference

Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells

31 March 2020

1 reference

Essential role for the p110 isoform in phosphoinositide 3-kinase activation and cell proliferation in acute myeloid leukemia

31 March 2020

1 reference

31 March 2020

1 reference

Mechanisms of Disease: the complement system and the pathogenesis of systemic lupus erythematosus

31 March 2020

1 reference

31 March 2020

1 reference

Is there a difference between chronic airway inflammation in chronic severe asthma and chronic obstructive pulmonary disease?

31 March 2020

1 reference

Neutrophils and immunity: challenges and opportunities

31 March 2020

1 reference

IL-17A-producing neutrophil-regulatory Tn lymphocytes

31 March 2020

1 reference

Degradation of human articular cartilage by neutrophils in synovial fluid

31 March 2020

1 reference

Polymorphonuclear granulocytes in rheumatic tissue destruction. II. Demonstration of PMNs in rheumatoid nodules by electron microscopy

31 March 2020

1 reference

Polymorphonuclear granulocytes in rheumatic tissue destruction. VI. The occurrence of PMNs in menisci of patients with rheumatoid arthritis

31 March 2020

1 reference

Polymorphonuclear granulocytes in rheumatic tissue destruction. III. an electron microscopic study of PMNs at the pannus-cartilage junction in rheumatoid arthritis

31 March 2020

1 reference

Role of polymorphs in inflammatory cartilage destruction in adjuvant arthritis of rats

31 March 2020

1 reference

Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genes

31 March 2020

1 reference

Effect of adalimumab on neutrophil function in patients with rheumatoid arthritis

31 March 2020

1 reference

Neutrophil recruitment in mast cell-dependent inflammation: inhibitory mechanisms of glucocorticoids

31 March 2020

1 reference

The role of endothelial PI3Kgamma activity in neutrophil trafficking

31 March 2020

1 reference

Mechanisms and implications of phosphoinositide 3-kinase delta in promoting neutrophil trafficking into inflamed tissue.

31 March 2020

1 reference

Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils

31 March 2020

1 reference

Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells

31 March 2020

1 reference

Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis

31 March 2020

1 reference

Development, migration, and survival of mast cells

31 March 2020

1 reference

Critical role of mast cells in inflammatory diseases and the effect of acute stress

31 March 2020

1 reference

Demonstration of mast cell chemotactic activity in synovial fluid from rheumatoid patients

31 March 2020

1 reference

Mast cells in the development of adaptive immune responses

31 March 2020

1 reference

Aggregation of the human high affinity immunoglobulin G receptor (FcgammaRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms.

31 March 2020

1 reference

Chemokines in rheumatic diseases

31 March 2020

1 reference

Chemokines: immunology's high impact factors

31 March 2020

1 reference

New concepts in the immunopathogenesis of multiple sclerosis

31 March 2020

1 reference

Immunology of multiple sclerosis

31 March 2020

1 reference

31 March 2020

1 reference

Phosphoinositide 3-kinase in disease: timing, location, and scaffolding

31 March 2020

1 reference

Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase

31 March 2020

1 reference

Gbetagammas and the Ras binding domain of p110gamma are both important regulators of PI(3)Kgamma signalling in neutrophils

31 March 2020

1 reference

NOX enzymes and the biology of reactive oxygen

31 March 2020

1 reference

The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

31 March 2020

1 reference

The role of phosphoinositides and phosphorylation in regulation of NADPH oxidase

31 March 2020

1 reference

A novel assay system implicates PtdIns(3,4)P(2), PtdIns(3)P, and PKC delta in intracellular production of reactive oxygen species by the NADPH oxidase

31 March 2020

1 reference

Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins

31 March 2020

1 reference

Integrated signalling pathways for mast-cell activation

31 March 2020

1 reference

Phosphoinositide 3-kinase gamma: a key modulator in inflammation and allergy

31 March 2020

1 reference

Signaling through PI3Kγ: a common platform for leukocyte, platelet and cardiovascular stress sensing

31 March 2020

1 reference

The phospholipase C gamma 1-dependent pathway of Fc epsilon RI-mediated mast cell activation is regulated independently of phosphatidylinositol 3-kinase

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRI2036

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17290298 AND SRC:MED&resulttype=core&format=json

Dimensions Publication ID

25 December 2019

1000993324

0 references

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017