P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac (Q24294423)

GOA release 2020-03-11

guanine

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author

Hediye Erdjument-Bromage

series ordinal

6

object named as

Hediye Erdjument-Bromage

author given names

Hediye

author last names

Erdjument-Bromage

1 reference

26 October 2023

7

Paul Tempst

Paul

Tempst

1 reference

26 October 2023

Phillip Thomas Hawkins

8

Phillip T Hawkins

Phillip T

Hawkins

1 reference

26 October 2023

1

Heidi C E Welch

Heidi C E

Welch

1 reference

26 October 2023

Len R Stephens

9

Len R

Stephens

1 reference

26 October 2023

2

W John Coadwell

W John

Coadwell

1 reference

26 October 2023

Christian D Ellson

3

Christian D

Ellson

1 reference

26 October 2023

G John Ferguson

series ordinal

4

author given names

G John

author last names

Ferguson

1 reference

26 October 2023

Simon R Andrews

series ordinal

5

author given names

Simon R

author last names

Andrews

1 reference

Phosphoinositide 3-kinase-dependent and -independent activation of the small GTPase Rac2 in human neutrophils

26 October 2023

language of work or name

English

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publication date

22 March 2002

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published in

Cell

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volume

108

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issue

6

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page(s)

809-21

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cites work

1 reference

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7 January 2021

Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation

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The small GTP-binding protein Rac promotes the dissociation of gelsolin from actin filaments in neutrophils

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Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases

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7 January 2021

The GTPase superfamily: a conserved switch for diverse cell functions

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Translocation of the Rac1 guanine nucleotide exchange factor Tiam1 induced by platelet-derived growth factor and lysophosphatidic acid

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7 January 2021

Moving in mysterious ways

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Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

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7 January 2021

Control of intramolecular interactions between the pleckstrin homology and Dbl homology domains of Vav and Sos1 regulates Rac binding.

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7 January 2021

PtdIns(3)P regulates the neutrophil oxidase complex by binding to the PX domain of p40phox

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7 January 2021

Ca2 /calmodulin-dependent protein kinase II regulates Tiam1 by reversible protein phosphorylation

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Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components

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7 January 2021

Characterization of membrane-localized and cytosolic Rac-GTPase-activating proteins in human neutrophil granulocytes: contribution to the regulation of NADPH oxidase

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7 January 2021

Lck regulates Vav activation of members of the Rho family of GTPases

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7 January 2021

Role of substrates and products of PI 3-kinase in regulating activation of Rac-related guanosine triphosphatases by Vav

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7 January 2021

Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13

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7 January 2021

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

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7 January 2021

G protein beta gamma subunit-dependent Rac-guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm)

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7 January 2021

Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices

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Rho family GTP-binding proteins in growth cone signalling

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7 January 2021

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

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Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro

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7 January 2021

Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.

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7 January 2021

Crystal structure and functional analysis of Ras binding to its effector phosphoinositide 3-kinase gamma

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7 January 2021

A comparative analysis of the phosphoinositide binding specificity of pleckstrin homology domains

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7 January 2021

Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways

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7 January 2021

Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

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7 January 2021

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

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7 January 2021

EPS8 and E3B1 transduce signals from Ras to Rac

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7 January 2021

The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101

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7 January 2021

Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B

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Regulation of phospholipase C by G proteins

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7 January 2021

Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton

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7 January 2021

Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway

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7 January 2021

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

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7 January 2021

alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase

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