miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT (Q24292808)

positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Nahum Sonenberg

11

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author name string

Marc R Fabian

1

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Maja K Cieplak

2

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Filipp Frank

3

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Masahiro Morita

4

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Jonathan Green

5

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Tharan Srikumar

6

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Bhushan Nagar

7

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Tadashi Yamamoto

8

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Brian Raught

9

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Thomas F Duchaine

Nature Structural & Molecular Biology

10

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language of work or name

English

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publication date

November 2011

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published in

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volume

18

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issue

11

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page(s)

1211-7

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cites work

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

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A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing

20 April 2017

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mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes

20 April 2017

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Identification of novel argonaute-associated proteins

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The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins

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Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

20 April 2017

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The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing

20 April 2017

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The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing

20 April 2017

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Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing

20 April 2017

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Structural basis of binding of P-body-associated proteins GW182 and ataxin-2 by the Mlle domain of poly(A)-binding protein

20 April 2017

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Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation

20 April 2017

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Poly(A) nuclease interacts with the C-terminal domain of polyadenylate-binding protein domain from poly(A)-binding protein

20 April 2017

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Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein

20 April 2017

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Human Ccr4-Not complexes contain variable deadenylase subunits

20 April 2017

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CCR4-NOT deadenylates mRNA associated with RNA-induced silencing complexes in human cells

20 April 2017

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Deadenylation is prerequisite for P-body formation and mRNA decay in mammalian cells

20 April 2017

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A specific role for the C-terminal region of the Poly(A)-binding protein in mRNA decay

20 April 2017

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Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae

20 April 2017

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CNOT2 depletion disrupts and inhibits the CCR4-NOT deadenylase complex and induces apoptotic cell death

20 April 2017

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Interaction of antiproliferative protein Tob with the CCR4-NOT deadenylase complex

20 April 2017

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Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth

20 April 2017

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Regulation of mRNA translation and stability by microRNAs

20 April 2017

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Gene silencing by microRNAs: contributions of translational repression and mRNA decay

20 April 2017

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GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay

20 April 2017

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The role of GW/P-bodies in RNA processing and silencing

21 January 2018

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A role for the P-body component GW182 in microRNA function

21 January 2018

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Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression.

21 January 2018

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The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression

21 January 2018

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A C-terminal silencing domain in GW182 is essential for miRNA function

21 January 2018

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Functional dissection of the human TNRC6 (GW182-related) family of proteins

21 January 2018

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The GW182 protein family in animal cells: new insights into domains required for miRNA-mediated gene silencing

21 January 2018

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Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression

21 January 2018

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The silencing domain of GW182 interacts with PABPC1 to promote translational repression and degradation of microRNA targets and is required for target release

21 January 2018

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Pervasive and cooperative deadenylation of 3'UTRs by embryonic microRNA families.

21 January 2018

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PAN3 encodes a subunit of the Pab1p-dependent poly(A) nuclease in Saccharomyces cerevisiae

21 January 2018

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Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps

21 January 2018

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Open source system for analyzing, validating, and storing protein identification data

21 January 2018

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MicroRNA Inhibition of Translation Initiation in Vitro by Targeting the Cap-Binding Complex eIF4F

21 January 2018

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Multifunctional deadenylase complexes diversify mRNA control

21 January 2018

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miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs

31 March 2020

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GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets

31 March 2020

1 reference

Repeating structure of cytoplasmic poly(A)-ribonucleoprotein

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21984185