Functions of the adapter protein Cas: signal convergence and the determination of cellular responses (Q24291815)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607844 AND SRC:MED&resulttype=core&format=json

12 November 2019

review article

1 reference

title

Functions of the adapter protein Cas: signal convergence and the determination of cellular responses (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607844 AND SRC:MED&resulttype=core&format=json

BCAR1 scaffold protein, Cas family member

12 November 2019

main subject

1 reference

regulation of apoptotic process

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Rebecca B Riggins

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607844 AND SRC:MED&resulttype=core&format=json

12 November 2019

author name string

Bouton AH

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607844 AND SRC:MED&resulttype=core&format=json

12 November 2019

Bruce-Staskal PJ

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607844 AND SRC:MED&resulttype=core&format=json

12 November 2019

language of work or name

English

0 references

publication date

1 October 2001

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607844 AND SRC:MED&resulttype=core&format=json

12 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607844 AND SRC:MED&resulttype=core&format=json

12 November 2019

volume

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607844 AND SRC:MED&resulttype=core&format=json

12 November 2019

issue

44

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607844 AND SRC:MED&resulttype=core&format=json

12 November 2019

page(s)

6448-6458

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11607844 AND SRC:MED&resulttype=core&format=json

Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin.

12 November 2019

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BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells

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PKC-dependent activation of FAK and src induces tyrosine phosphorylation of Cas and formation of Cas-Crk complexes

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Regulation of c-SRC activity and function by the adapter protein CAS

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The role of SRC-CAS interactions in cellular transformation: ectopic expression of the carboxy terminus of CAS inhibits SRC-CAS interaction but has no effect on cellular transformation

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Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration

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Tyrosine phosphorylation of p130(cas) by bombesin, lysophosphatidic acid, phorbol esters, and platelet-derived growth factor. Signaling pathways and formation of a p130(cas)-Crk complex

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Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3'-kinase and formation of a p130(Cas).Crk complex

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Suppression of ultraviolet irradiation-induced apoptosis by overexpression of focal adhesion kinase in Madin-Darby canine kidney cells

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PR-39, a syndecan-inducing antimicrobial peptide, binds and affects p130(Cas).

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Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells

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Extracellular-regulated kinase activation and CAS/Crk coupling regulate cell migration and suppress apoptosis during invasion of the extracellular matrix

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Focal adhesions - the cytoskeletal connection

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BCR/ABL-induced leukemogenesis causes phosphorylation of Hef1 and its association with Crkl

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An immunoglobulin superfamily-like domain unique to the Yersinia pseudotuberculosis invasin protein is required for stimulation of bacterial uptake via integrin receptors

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7 January 2021

A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A

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7 January 2021

The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway

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7 January 2021

Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells

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7 January 2021

Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas

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7 January 2021

CCKA receptor activation stimulates p130(Cas) tyrosine phosphorylation, translocation, and association with Crk in rat pancreatic acinar cells.

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7 January 2021

Plasminogen activator inhibitor-1 and prognosis in primary breast cancer

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7 January 2021

Integrins and anoikis

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7 January 2021

Surfing pathogens and the lessons learned for actin polymerization.

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7 January 2021

Cell adhesion regulates the interaction between the docking protein p130(Cas) and the 14-3-3 proteins

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7 January 2021

Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST.

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7 January 2021

Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST

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7 January 2021

Integrin signaling: specificity and control of cell survival and cell cycle progression

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7 January 2021

p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor.

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7 January 2021

Cas mediates transcriptional activation of the serum response element by Src.

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7 January 2021

Src kinase plays an essential role in integrin-mediated tyrosine phosphorylation of Crk-associated substrate p130Cas

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7 January 2021

Protein tyrosine phosphatase-dependent proteolysis of focal adhesion complexes in endothelial cell apoptosis

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p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase

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p130(Cas), an assembling molecule of actin filaments, promotes cell movement, cell migration, and cell spreading in fibroblasts

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Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex

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7 January 2021

CAS/Crk coupling serves as a "molecular switch" for induction of cell migration

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7 January 2021

Src family kinases are required for integrin but not PDGFR signal transduction.

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7 January 2021

Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells

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7 January 2021

Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone

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7 January 2021

A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein

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7 January 2021

Fibroblast growth factor receptor-1-mediated endothelial cell proliferation is dependent on the Src homology (SH) 2/SH3 domain-containing adaptor protein Crk

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7 January 2021

Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae

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7 January 2021

The docking protein HEF1 is an apoptotic mediator at focal adhesion sites

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7 January 2021

Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain

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7 January 2021

Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments

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7 January 2021

Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry

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7 January 2021

Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas)

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7 January 2021

NSP1 defines a novel family of adaptor proteins linking integrin and tyrosine kinase receptors to the c-Jun N-terminal kinase/stress-activated protein kinase signaling pathway

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7 January 2021

Binding of Transforming Protein, P47 gag-crk , to a Broad Range of Phosphotyrosine-containing Proteins

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7 January 2021

Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins

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7 January 2021

Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins

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7 January 2021

Characterization of p47gag-crk, a novel oncogene product with sequence similarity to a putative modulatory domain of protein-tyrosine kinases and phospholipase C.

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7 January 2021

Evidence that SH2 domains promote processive phosphorylation by protein-tyrosine kinases

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7 January 2021

v-src-Induced Cell Shape Changes in Rat Fibroblasts Require New Gene Transcription and Precede Loss of Focal Adhesions

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7 January 2021

The integrin alpha 7 cytoplasmic domain regulates cell migration, lamellipodia formation, and p130CAS/Crk coupling

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7 January 2021

Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes

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7 January 2021

Rho-dependent and -independent tyrosine phosphorylation of focal adhesion kinase, paxillin and p130Cas mediated by Ret kinase

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7 January 2021

Requirements for localization of p130cas to focal adhesions

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7 January 2021

Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase

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7 January 2021

CIZ, a zinc finger protein that interacts with p130(cas) and activates the expression of matrix metalloproteinases

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7 January 2021

Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts.

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7 January 2021

Galpha12 and Galpha13 stimulate Rho-dependent tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130 Crk-associated substrate

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7 January 2021

Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs

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7 January 2021

Epidermal growth factor modulates tyrosine phosphorylation of p130Cas. Involvement of phosphatidylinositol 3'-kinase and actin cytoskeleton

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7 January 2021

Integrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle

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7 January 2021

Integrin signalling: a new Cas(t) of characters enters the stage

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7 January 2021

Induced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.

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7 January 2021

The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions

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7 January 2021

Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas

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7 January 2021

Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs

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7 January 2021

SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading

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7 January 2021

Analysis of FAK-associated signaling pathways in the regulation of cell cycle progression

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7 January 2021

Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins

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7 January 2021

Nerve growth factor stimulates the tyrosine phosphorylation of endogenous Crk-II and augments its association with p130Cas in PC-12 cells

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7 January 2021

Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways

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7 January 2021

p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene

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7 January 2021

Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins

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7 January 2021

Melanoma Growth Stimulatory Activity Signaling through the Class II Interleukin-8 Receptor Enhances the Tyrosine Phosphorylation of Crk-Associated Substrate, p130, and a 70-Kilodalton Protein

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7 January 2021

Analysis of protein kinase specificity by peptide libraries and prediction of in vivo substrates

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7 January 2021

Use of an oriented peptide library to determine the optimal substrates of protein kinases

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7 January 2021

ErbB2 is necessary for induction of carcinoma cell invasion by ErbB family receptor tyrosine kinases

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7 January 2021

Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates

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7 January 2021

Tyrosine phosphorylation and association of p130Cas and c-Crk II by ANG II in vascular smooth muscle cells

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7 January 2021

C3G, a guanine nucleotide-releasing protein expressed ubiquitously, binds to the Src homology 3 domains of CRK and GRB2/ASH proteins

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7 January 2021

Integrin-mediated signal transduction in cells lacking focal adhesion kinase p125FAK.

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7 January 2021

Identification of BCAR3 by a random search for genes involved in antiestrogen resistance of human breast cancer cells

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7 January 2021

Bcar1/p130Cas protein and primary breast cancer: prognosis and response to tamoxifen treatment.

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7 January 2021

BCAR1/p130Cas expression in untreated and acquired tamoxifen-resistant human breast carcinomas.

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7 January 2021

c-Src protein expression is increased in human breast cancer. An immunohistochemical and biochemical analysis

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7 January 2021

Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

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7 January 2021

Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix

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7 January 2021

Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR

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7 January 2021

CAS/Crk signalling mediates uptake of Yersinia into human epithelial cells

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7 January 2021

Transmembrane tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas

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7 January 2021

c-Src signaling induced by the adapters Sin and Cas is mediated by Rap1 GTPase

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7 January 2021

Dissociation of FAK/p130(CAS)/c-Src complex during mitosis: role of mitosis-specific serine phosphorylation of FAK

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7 January 2021

Src and Cas mediate JNK activation but not ERK1/2 and p38 kinases by reactive oxygen species

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7 January 2021

Growth hormone stimulates the tyrosine phosphorylation and association of p125 focal adhesion kinase (FAK) with JAK2. Fak is not required for stat-mediated transcription

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7 January 2021