Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads (Q24291512)

2

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K Sugamura

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C H Heldin

4

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P ten Dijke

5

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S Itoh

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

6

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language of work or name

English

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publication date

1 August 2001

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published in

The EMBO Journal

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volume

20

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issue

15

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page(s)

4132-42

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cites work

1 reference

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

19 March 2017

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A mechanism of suppression of TGF-beta/SMAD signaling by NF-kappa B/RelA

19 March 2017

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Possible involvement of a novel STAM-associated molecule "AMSH" in intracellular signal transduction mediated by cytokines

19 March 2017

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Roles of pathway-specific and inhibitory Smads in activin receptor signaling

19 March 2017

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TGF-beta signal transduction

19 March 2017

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Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

19 March 2017

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Vascular MAD s: Two novel MAD -related genes selectively inducible by flow in human vascular endothelium

19 March 2017

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Receptor-associated Mad homologues synergize as effectors of the TGF-beta response

19 March 2017

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The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

19 March 2017

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Mad-related genes in the human

19 March 2017

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Activin A induces apoptotic cell death

19 March 2017

1 reference

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Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

19 March 2017

1 reference

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TGF-β signalling from cell membrane to nucleus through SMAD proteins

19 March 2017

1 reference

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BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6

19 March 2017

1 reference

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Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells

19 March 2017

1 reference

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ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling

19 March 2017

1 reference

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Smads: transcriptional activators of TGF-beta responses

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Transforming growth factor beta1 induces nuclear export of inhibitory Smad7

19 March 2017

1 reference

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Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors

19 March 2017

1 reference

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Induction of inhibitory Smad6 and Smad7 mRNA by TGF-beta family members

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Opposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Characterization of functional domains within Smad4/DPC4

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Phosphorylation of Ser165 in TGF-beta type I receptor modulates TGF-beta1-induced cellular responses

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Transcriptional control by the TGF-beta/Smad signaling system

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Positive and negative regulation of TGF-beta signaling

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Smad7 differentially regulates transforming growth factor beta-mediated signaling pathways

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Role of p300, a transcriptional coactivator, in signalling of TGF-beta

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Intracellular signaling of osteogenic protein-1 through Smad5 activation

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Induction of Smad6 mRNA by bone morphogenetic proteins

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Bone morphogenetic proteins: an unconventional approach to isolation of first mammalian morphogens.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of chordin to BMP-4.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Fused protein domains inhibit DNA binding by LexA

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Silencing of TGF-beta signalling by the pseudoreceptor BAMBI.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Smad6 functions as an intracellular antagonist of some TGF-beta family members during Xenopus embryogenesis.

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

The bone morphogenetic protein family: multifunctional cellular regulators in the embryo and adult

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

30 May 2018

TGF-β receptor signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Smad6 inhibits signalling by the TGF-β superfamily

30 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=149146

Interdependent SMAD and JNK signaling in transforming growth factor-beta-mediated transcription

29 November 2018

1 reference

12 December 2020

Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling

1 reference

12 December 2020

Signal transduction by bone morphogenetic proteins

1 reference

12 December 2020

The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation

1 reference

12 December 2020

Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression

1 reference

12 December 2020

Transforming growth factor-beta induces collagenase-3 expression by human gingival fibroblasts via p38 mitogen-activated protein kinase

1 reference

12 December 2020