Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12 (Q22254620)

28 March 2023

S C Johnston

2

S C

Johnston

1 reference

28 March 2023

J Tang

3

J

Tang

1 reference

28 March 2023

M Stahl

4

M

Stahl

1 reference

28 March 2023

J F Tobin

5

J F

Tobin

1 reference

28 March 2023

W S Somers

6

W S

Somers

1 reference

Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface

28 March 2023

language of work or name

English

0 references

publication date

17 July 2000

0 references

published in

The EMBO Journal

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volume

19

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issue

14

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page(s)

3530-41

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cites work

1 reference

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Efficiency of signalling through cytokine receptors depends critically on receptor orientation

19 March 2017

1 reference

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Epstein–Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin

19 March 2017

1 reference

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The X-ray structure of a growth hormone-prolactin receptor complex

19 March 2017

1 reference

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Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells

19 March 2017

1 reference

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Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor

19 March 2017

1 reference

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Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells

19 March 2017

1 reference

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Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

19 March 2017

1 reference

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Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells

19 March 2017

1 reference

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Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme

19 March 2017

1 reference

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Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

19 March 2017

1 reference

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Raster3D: photorealistic molecular graphics

19 March 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

19 March 2017

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Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

21 January 2018

1 reference

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Crystallographic R factor refinement by molecular dynamics

19 March 2017

1 reference

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The CCP4 suite: programs for protein crystallography

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Analysis of the multiple interactions between IL-12 and the high affinity IL-12 receptor complex

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

The immunoglobulin fold. Structural classification, sequence patterns and common core

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Homology of the p40 subunit of natural killer cell stimulatory factor (NKSF) with the extracellular domain of the interleukin-6 receptor

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

A hot spot of binding energy in a hormone-receptor interface

19 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Anatomy of hot spots in protein interfaces

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Structural design and molecular evolution of a cytokine receptor superfamily

7 April 2017

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

7 April 2017

https://api.crossref.org/works/10.1093/EMBOJ/19.14.3530

The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Characterization of the receptor binding determinants of granulocyte colony stimulating factor

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

A mixed-charge pair in human interleukin 4 dominates high-affinity interaction with the receptor alpha chain

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Hematopoietic receptor complexes

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Two distinct and independent sites on IL-6 trigger gp 130 dimer formation and signalling

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Improved vectors for stable expression of foreign genes in mammalian cells by use of the untranslated leader sequence from EMC virus

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Differential utilization of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-alpha.

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Identification of a critical ligand binding determinant of the human erythropoietin receptor. Evidence for common ligand binding motifs in the cytokine receptor family

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

Oligomerization of Chicken Acetylcholinesterase Does Not Require Intersubunit Disulfide Bonds

27 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=313992

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

27 September 2017

1 reference

https://api.crossref.org/works/10.1093/EMBOJ/19.14.3530

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/EMBOJ/19.14.3530

PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/EMBOJ/19.14.3530

AMoRe: an automated package for molecular replacement

21 January 2018

1 reference

https://api.crossref.org/works/10.1093/EMBOJ/19.14.3530

21 January 2018

1 reference

12 December 2020

Comparison of a structural and a functional epitope

1 reference

12 December 2020

The conformational stability of a non-covalent dimer of a platelet-derived growth factor-B mutant lacking the two cysteines involved in interchain disulfide bonds

1 reference

12 December 2020

High affinity interleukin-6 receptor is a hexameric complex consisting of two molecules each of interleukin-6, interleukin-6 receptor, and gp-130

1 reference

12 December 2020

IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses

1 reference

12 December 2020

Reduced incidence and severity of collagen-induced arthritis in interleukin-12-deficient mice

1 reference

12 December 2020

Identification of a Ligand-binding Site on the Granulocyte Colony-stimulating Factor Receptor by Molecular Modeling and Mutagenesis

1 reference

12 December 2020

Interleukin-12: a cytokine at the interface of inflammation and immunity

1 reference

12 December 2020

The Immunoglobulin Fold

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/19.14.3530

0 references

PMC publication ID

313992

0 references