Current Insights into Molecular Mechanisms of Alzheimer Disease and Their Implications for Therapeutic Approaches (Q22241945)

PubMed

7 February 2023

Samir Kumar-Singh

3

Samir

Kumar-Singh

1 reference

PubMed

7 February 2023

Bianca Van Broeck

1

Bianca

Van Broeck

1 reference

PubMed

17622778

Neurodegenerative Diseases

7 February 2023

language of work or name

English

0 references

publication date

2007

0 references

published in

0 references

volume

4

0 references

issue

5

0 references

page(s)

349-365

0 references

cites work

Cell biology of protein misfolding: the examples of Alzheimer's and Parkinson's diseases

1 reference

An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants.

21 January 2018

1 reference

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

21 January 2018

1 reference

Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).

21 January 2018

1 reference

Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-Secretase complex

21 January 2018

1 reference

TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity

21 January 2018

1 reference

Identification of a new presenilin-dependent zeta-cleavage site within the transmembrane domain of amyloid precursor protein.

21 January 2018

1 reference

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

21 January 2018

1 reference

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

21 January 2018

1 reference

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

21 January 2018

1 reference

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

21 January 2018

1 reference

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression

21 January 2018

1 reference

Wild-type presenilin 1 protects against Alzheimer disease mutation-induced amyloid pathology.

21 January 2018

1 reference

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

21 January 2018

1 reference

Mean age-of-onset of familial alzheimer disease caused by presenilin mutations correlates with both increased Abeta42 and decreased Abeta40.

21 January 2018

1 reference

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

21 January 2018

1 reference

Human presenilin-1, but not familial Alzheimer's disease (FAD) mutants, facilitate Caenorhabditis elegans Notch signalling independently of proteolytic processing

21 January 2018

1 reference

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

21 January 2018

1 reference

APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

21 January 2018

1 reference

APP duplication is sufficient to cause early onset Alzheimer's dementia with cerebral amyloid angiopathy

21 January 2018

1 reference

Promoter mutations that increase amyloid precursor-protein expression are associated with Alzheimer disease

21 January 2018

1 reference

Genetic risk and transcriptional variability of amyloid precursor protein in Alzheimer's disease

21 January 2018

1 reference

Unusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease

21 January 2018

1 reference

Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease

21 January 2018

1 reference

Pathogenic APP mutations near the gamma-secretase cleavage site differentially affect Abeta secretion and APP C-terminal fragment stability.

21 January 2018

1 reference

Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease

21 January 2018

1 reference

Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology.

21 January 2018

1 reference

Abeta42 is essential for parenchymal and vascular amyloid deposition in mice

21 January 2018

1 reference

Abeta40 inhibits amyloid deposition in vivo.

21 January 2018

1 reference

In vitro studies of Flemish, Dutch, and wild-type beta-amyloid provide evidence for two-staged neurotoxicity

21 January 2018

1 reference

Dense-core senile plaques in the Flemish variant of Alzheimer's disease are vasocentric

21 January 2018

1 reference

Presenilin 1 mutations activate gamma 42-secretase but reciprocally inhibit epsilon-secretase cleavage of amyloid precursor protein (APP) and S3-cleavage of notch

21 January 2018

1 reference

Separation of presenilin function in amyloid beta-peptide generation and endoproteolysis of Notch

21 January 2018

1 reference

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

21 January 2018

1 reference

Skeletal and CNS defects in Presenilin-1-deficient mice

21 January 2018

1 reference

Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1.

21 January 2018

1 reference

Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression.

21 January 2018

1 reference

PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations

21 January 2018

1 reference

Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations

21 January 2018

1 reference

A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations

21 January 2018

1 reference

Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling

21 January 2018

1 reference

Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production

21 January 2018

1 reference

Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment

21 January 2018

1 reference

Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios.

21 January 2018

1 reference

A novel presenilin 1 mutation associated with Pick's disease but not beta-amyloid plaques

21 January 2018

1 reference

Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations

21 January 2018

1 reference

Frontotemporal dementia and parkinsonism associated with the IVS1 1G->A mutation in progranulin: a clinicopathologic study

21 January 2018

1 reference

Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17

21 January 2018

1 reference

Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21

21 January 2018

1 reference

Cerebral microvascular pathology in aging and Alzheimer's disease

21 January 2018

1 reference

Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls

21 January 2018

1 reference

Abeta is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis.

21 January 2018

1 reference

Chronic reduction of cerebral blood flow in the adult rat: late-emerging CA1 cell loss and memory dysfunction

21 January 2018

1 reference

Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration.

21 January 2018

1 reference

Acute gamma-secretase inhibition improves contextual fear conditioning in the Tg2576 mouse model of Alzheimer's disease.

21 January 2018

1 reference

Chronic treatment with the gamma-secretase inhibitor LY-411,575 inhibits beta-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation

21 January 2018

1 reference

BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

1 reference

In vivo inhibition of Abeta production by memapsin 2 (beta-secretase) inhibitors

21 January 2018

1 reference

A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity

21 January 2018

1 reference

Cyclohexanehexol inhibitors of Abeta aggregation prevent and reverse Alzheimer phenotype in a mouse model.

21 January 2018

1 reference

Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death

21 January 2018

1 reference

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

21 January 2018

1 reference

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

21 January 2018

1 reference

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

21 January 2018

1 reference

Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

21 January 2018

1 reference

Tau protein phosphorylation as a therapeutic target in Alzheimer's disease

21 January 2018

1 reference

Transgenic mouse models with tau pathology to test therapeutic agents for Alzheimer's disease.

21 January 2018

1 reference

Angiogenesis in life, disease and medicine

21 January 2018

1 reference

Molecular and cellular mechanisms of neuroprotection by vascular endothelial growth factor

21 January 2018

1 reference

Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS.

21 January 2018

1 reference

Vascular endothelial growth factor in Alzheimer's disease and experimental cerebral ischemia

21 January 2018

1 reference

Co-accumulation of vascular endothelial growth factor with beta-amyloid in the brain of patients with Alzheimer's disease

21 January 2018

1 reference

Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1

21 January 2018

1 reference

Transgenic overexpression of platelet-derived growth factor-C in the mouse heart induces cardiac fibrosis, hypertrophy, and dilated cardiomyopathy

21 January 2018

1 reference

Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis

21 January 2018

1 reference

Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice.

21 January 2018

1 reference

Abnormal bone growth and selective translational regulation in basic fibroblast growth factor (FGF-2) transgenic mice

21 January 2018

1 reference

Neuritic involvement within bFGF immunopositive plaques of Alzheimer's disease

21 January 2018

1 reference

VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death

21 January 2018

1 reference

CARP, a cardiac ankyrin repeat protein, is up-regulated during wound healing and induces angiogenesis in experimental granulation tissue

21 January 2018

1 reference

Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling

21 January 2018

1 reference

Rosiglitazone facilitates angiogenic progenitor cell differentiation toward endothelial lineage: a new paradigm in glitazone pleiotropy

21 January 2018

1 reference

Endothelial PAS domain protein 1 gene promotes angiogenesis through the transactivation of both vascular endothelial growth factor and its receptor, Flt-1.

21 January 2018

1 reference

Expression of the oxygen-regulated protein ORP150 accelerates wound healing by modulating intracellular VEGF transport.

21 January 2018

1 reference

PC cell-derived growth factor (PCDGF/GP88, progranulin) stimulates migration, invasiveness and VEGF expression in breast cancer cells

21 January 2018

1 reference

Trophic factors counteract elevated FGF-2-induced inhibition of adult neurogenesis

21 January 2018

1 reference

7 January 2021

Increased intrathecal levels of the angiogenic factors VEGF and TGF-beta in Alzheimer's disease and vascular dementia

1 reference

7 January 2021

Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1.

1 reference

7 January 2021

Stabilized HIF-1alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer

1 reference

7 January 2021

Neovascularization of ischemic tissues by gene delivery of the extracellular matrix protein Del-1

1 reference

7 January 2021

Dementia with prominent frontotemporal features associated with L113P presenilin 1 mutation

1 reference

7 January 2021

Genetics and pathology of alpha-secretase site AbetaPP mutations in the understanding of Alzheimer's disease.

1 reference

7 January 2021

release_vlsalierrbctjmnipyyu7e3v4a

Identifiers

DOI

10.1159/000105156

0 references

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/vlsalierrbctjmnipyyu7e3v4a

24 November 2022

mapped directly with Wikidata item