Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3 (Q22008053)

protein homodimerization activity

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

I W Leung

1

I W

Leung

1 reference

PubMed

PubMed publication ID

9829970

7 February 2023

N Lassam

series ordinal

2

author given names

N

author last names

Lassam

1 reference

PubMed

PubMed publication ID

9829970

Journal of Biological Chemistry

7 February 2023

language of work or name

English

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publication date

4 December 1998

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published in

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volume

273

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issue

49

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page(s)

32408-15

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cites work

The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.

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MST/MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase

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Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2

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Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 activation inhibited by kinase negative forms of MLK3 and DLK mixed lineage kinases

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Dual leucine zipper-bearing kinase (DLK) activates p46SAPK and p38mapk but not ERK2.

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Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains

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Complete nucleotide sequence, expression, and chromosomal localisation of human mixed-lineage kinase 2

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Identification of a dual leucine zipper kinase involved in rat fracture repair

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Cloning of a novel putative protein kinase having a leucine zipper domain from human brain

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Molecular Cloning and Functional Expression of a cDNA Encoding a New Member of Mixed Lineage Protein Kinase from Human Brain

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A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases

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The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins

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High resolution NMR solution structure of the leucine zipper domain of the c-Jun homodimer

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Crystal structure of the heterodimeric bZIP transcription factor c-Fos-c-Jun bound to DNA

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A carboxyl terminal leucine zipper is required for tyrosine hydroxylase tetramer formation

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Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe

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Leucine zipper-like domain regulates the autophosphorylation and the transforming activity of P130gag-fps

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Receptor signaling: dimerization and beyond

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Effect of dimerization on signal transduction and biological function of oncogenic Ros, insulin, and insulin-like growth factor I receptors.

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Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin

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The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3

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The complexity of Raf-1 regulation

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Mechanisms regulating Raf-1 activity in signal transduction pathways

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Activation of the Raf-1 kinase cascade by coumermycin-induced dimerization.

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Oligomerization activates c-Raf-1 through a Ras-dependent mechanism

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HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway

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7 January 2021

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6

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Signaling from the small GTP-binding proteins Rac1 and Cdc42 to the c-Jun N-terminal kinase/stress-activated protein kinase pathway. A role for mixed lineage kinase 3/protein-tyrosine kinase 1, a novel member of the mixed lineage kinase family

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Mutations in the leucine zipper of the human immunodeficiency virus type 1 transmembrane glycoprotein affect fusion and infectivity

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7 January 2021