PAX interacting (with transcription-activation domain) protein 1 (Q21988404)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q6NZQ4

BRCT domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

6 references

14 February 2019

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

14 February 2019

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

14 February 2019

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

14 February 2019

Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

14 February 2019

PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

14 February 2019

The transcription factor Pax5 regulates its target genes by recruiting chromatin-modifying proteins in committed B cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

cell component

nuclear matrix

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

1 reference

14 February 2019

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

1 reference

14 February 2019

TAS

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

5 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

14 February 2019

PTIP promotes chromatin changes critical for immunoglobulin class switch recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

IDA

14 February 2019

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

IDA

14 February 2019

PTIP, a novel BRCT domain-containing protein interacts with Pax2 and is associated with active chromatin

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

IDA

MLL3/4 complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

chromosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

1 reference

14 February 2019

response to ionizing radiation

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

positive regulation of histone H3-K36 methylation

1 reference

14 February 2019

PTIP promotes chromatin changes critical for immunoglobulin class switch recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

DNA recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

1 reference

14 February 2019

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6NZQ4&geneProductId=UniProtKB:Q6NZQ4

1 reference

27 March 2018

chorion development

1 reference

14 February 2019

An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

DNA damage response, signal transduction by p53 class mediator

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

positive regulation of transcription initiation from RNA polymerase II promoter

PTIP promotes chromatin changes critical for immunoglobulin class switch recombination

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

14 February 2019

Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6NZQ4&geneProductId=UniProtKB:Q6NZQ4

1 reference

27 March 2018

positive regulation of histone acetylation

1 reference

14 February 2019

PTIP promotes chromatin changes critical for immunoglobulin class switch recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

vasculogenesis

1 reference

14 February 2019

An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

positive regulation of isotype switching

1 reference

14 February 2019

PTIP promotes chromatin changes critical for immunoglobulin class switch recombination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

histone H3-K4 methylation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

positive regulation of histone H3-K4 methylation

regulation of cell cycle G2/M phase transition

1 reference

14 February 2019

Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

positive regulation of response to DNA damage stimulus

1 reference

14 February 2019

Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

adipose tissue development

1 reference

14 February 2019

Histone methylation regulator PTIP is required for PPARgamma and C/EBPalpha expression and adipogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

positive regulation of isotype switching to IgG isotypes

1 reference

14 February 2019

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

positive regulation of protein ubiquitination

1 reference

14 February 2019

PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

DNA repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

1 reference

14 February 2019

endothelial cell migration

1 reference

14 February 2019

An allelic series uncovers novel roles of the BRCT domain-containing protein PTIP in mouse embryonic vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q6NZQ4

negative regulation of DNA-binding transcription factor activity

1 reference

14 January 2019

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q6NZQ4&geneProductId=UniProtKB:Q6NZQ4

1 reference

InterPro Release 71.0