Par-3 family cell polarity regulator (Q21987386)

http://www.ebi.ac.uk/interpro/protein/Q99NH2

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

PDZ domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Par3/HAL, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

5 references

14 February 2019

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

14 February 2019

The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

14 February 2019

Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

14 February 2019

FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

14 February 2019

Loss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

protein kinase C binding

1 reference

24 April 2018

Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99NH2&geneProductId=UniProtKB:Q99NH2

lipid binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

1 reference

14 February 2019

protein phosphatase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

identical protein binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

phosphatidylinositol binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

cell component

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

1 reference

14 February 2019

cell-cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

3 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

14 February 2019

E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

bicellular tight junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

14 February 2019

14 February 2019

The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

1 reference

14 February 2019

spindle

1 reference

14 February 2019

PAR-3 defines a central subdomain of the cortical actin cap in mouse eggs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

internode region of axon

1 reference

14 February 2019

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

Schmidt-Lanterman incisure

1 reference

14 February 2019

Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

cell junction

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

14 February 2019

14 February 2019

Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

lateral loop

1 reference

14 February 2019

Pals1 is a major regulator of the epithelial-like polarization and the extension of the myelin sheath in peripheral nerves

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

1 reference

14 February 2019

endomembrane system

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

1 reference

14 February 2019

apical junction complex

1 reference

24 April 2018

Nectins localize Willin to cell-cell junctions

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99NH2&geneProductId=UniProtKB:Q99NH2

adherens junction

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99NH2&geneProductId=UniProtKB:Q99NH2

3 references

24 April 2018

24 April 2018

FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99NH2&geneProductId=UniProtKB:Q99NH2

24 April 2018

Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99NH2&geneProductId=UniProtKB:Q99NH2

soma

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

axonal growth cone

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

3 references

14 February 2019

14 February 2019

PAR-3 defines a central subdomain of the cortical actin cap in mouse eggs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

adherens junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

4 references

14 February 2019

14 February 2019

Association of ASIP/mPAR-3 with adherens junctions of mouse neuroepithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

14 February 2019

FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

apical plasma membrane

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

protein-containing complex

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

biological process

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

1 reference

14 February 2019

positive regulation of receptor internalization

1 reference

14 February 2019

Spatial regulation of VEGF receptor endocytosis in angiogenesis

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

centrosome localization

1 reference

14 February 2019

Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

negative regulation of peptidyl-threonine phosphorylation

1 reference

14 February 2019

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

regulation of actin filament-based process

1 reference

14 February 2019

Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

myelination in peripheral nervous system

1 reference

14 February 2019

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

cell division

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

1 reference

14 February 2019

establishment or maintenance of cell polarity

TAS

1 reference

14 February 2019

The mammalian homologue of the Caenorhabditis elegans polarity protein PAR-6 is a binding partner for the Rho GTPases Cdc42 and Rac1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

positive regulation of myelination

TAS

1 reference

14 February 2019

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

cell cycle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

1 reference

14 February 2019

apical constriction

1 reference

14 February 2019

Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

microtubule cytoskeleton organization

1 reference

24 April 2018

Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99NH2&geneProductId=UniProtKB:Q99NH2

wound healing, spreading of cells

1 reference

14 February 2019

Par3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

cell-cell adhesion

IC

1 reference

14 February 2019

Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

regulation of cellular localization

IC

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

microtubule cytoskeleton organization

cell adhesion

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

protein localization

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

establishment of cell polarity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

establishment or maintenance of epithelial cell apical/basal polarity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

establishment of centrosome localization

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99NH2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99NH2

PDZ domain

1 reference

InterPro Release 71.0