NK6 homeobox 1 (Q21987308)

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mammalian protein found in Mus musculus

Nkx6-1
homeodomain transcription factor Nkx6.1
homeobox protein NK-6 homolog A
Drosophila NK transcription factor related, gene family 6, locus 1
homeobox protein Nkx-6.1
NK6 transcription factor related, locus 1

Language	Label	Description	Also known as
English	NK6 homeobox 1	mammalian protein found in Mus musculus	Nkx6-1 homeodomain transcription factor Nkx6.1 homeobox protein NK-6 homolog A Drosophila NK transcription factor related, gene family 6, locus 1 homeobox protein Nkx-6.1 NK6 transcription factor related, locus 1

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

Homeobox protein NKX-6.1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99MA9

Homeobox-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q99MA9

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

basic helix-loop-helix transcription factor

1 reference

based on heuristic

inferred from protein domain or family

Helix-turn-helix motif, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox domain, metazoa, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

DNA-binding transcription repressor activity, RNA polymerase II-specific

determination method or standard

4 references

24 April 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MA9&geneProductId=UniProtKB:Q99MA9

determination method or standard

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MA9&geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

DNA-binding transcription factor activity

determination method or standard

4 references

7 November 2018

Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MA9&geneProductId=UniProtKB:Q99MA9

determination method or standard

7 November 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MA9&geneProductId=UniProtKB:Q99MA9

determination method or standard

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MA9&geneProductId=UniProtKB:Q99MA9

determination method or standard

7 November 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MA9&geneProductId=UniProtKB:Q99MA9

determination method or standard

sequence-specific DNA binding

determination method or standard

RNA polymerase II cis-regulatory region sequence-specific DNA binding

determination method or standard

3 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

DNA-binding transcription factor activity

determination method or standard

5 references

14 February 2019

Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

sequence-specific DNA binding

determination method or standard

4 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

determination method or standard

8 references

7 November 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MA9&geneProductId=UniProtKB:Q99MA9

determination method or standard

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MA9&geneProductId=UniProtKB:Q99MA9

determination method or standard

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MA9&geneProductId=UniProtKB:Q99MA9

determination method or standard

7 November 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MA9&geneProductId=UniProtKB:Q99MA9

determination method or standard

7 November 2018

Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MA9&geneProductId=UniProtKB:Q99MA9

determination method or standard

7 November 2018

The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MA9&geneProductId=UniProtKB:Q99MA9

determination method or standard

7 November 2018

Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MA9&geneProductId=UniProtKB:Q99MA9

determination method or standard

7 November 2018

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q99MA9&geneProductId=UniProtKB:Q99MA9

determination method or standard

determination method or standard

9 references

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

The foxa2 gene controls the birth and spontaneous degeneration of dopamine neurons in old age

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

biological process

cell differentiation

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

positive regulation of glial cell differentiation

determination method or standard

1 reference

14 February 2019

Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

response to nicotine

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

oligodendrocyte differentiation

determination method or standard

1 reference

14 February 2019

Generation of oligodendrocyte precursor cells from mouse dorsal spinal cord independent of Nkx6 regulation and Shh signaling

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

negative regulation of glial cell differentiation

determination method or standard

1 reference

14 February 2019

Multiple dorsoventral origins of oligodendrocyte generation in the spinal cord and hindbrain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

cellular response to cytokine stimulus

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

multicellular organism development

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

cellular response to peptide hormone stimulus

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

positive regulation of neuron differentiation

determination method or standard

1 reference

14 February 2019

A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

central nervous system neuron differentiation

determination method or standard

1 reference

14 February 2019

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

regulation of neuron migration

determination method or standard

1 reference

14 February 2019

Nkx6-1 controls the identity and fate of red nucleus and oculomotor neurons in the mouse midbrain

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

smoothened signaling pathway

determination method or standard

1 reference

14 February 2019

FKBP8 cell-autonomously controls neural tube patterning through a Gli2- and Kif3a-dependent mechanism

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

type B pancreatic cell development

determination method or standard

1 reference

14 February 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

endocrine pancreas development

determination method or standard

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

regulation of transcription by RNA polymerase II

determination method or standard

3 references

14 February 2019

Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

regulation of insulin secretion

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

neuron migration

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

type B pancreatic cell differentiation

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

type B pancreatic cell proliferation

determination method or standard

cell differentiation

determination method or standard

3 references

14 February 2019

NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

NKX6 transcription factor activity is required for alpha- and beta-cell development in the pancreas

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q99MA9

determination method or standard

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000042716

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000042716

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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