Mix1 homeobox-like 1 (Xenopus laevis) (Q21987246)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9WUI0

Homeobox domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Homeobox, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

RNA polymerase II cis-regulatory region sequence-specific DNA binding

3 references

27 March 2018

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

27 March 2018

Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

27 March 2018

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

sequence-specific DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

1 reference

9 May 2019

protein homodimerization activity

1 reference

9 May 2019

Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

DNA-binding transcription activator activity, RNA polymerase II-specific

10 references

27 March 2018

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

27 March 2018

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

27 March 2018

Transcriptional activation by the Mixl1 homeodomain protein in differentiating mouse embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

27 March 2018

Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

27 March 2018

Pdgfrα and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

9 May 2019

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Pdgfrα and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Transcriptional activation by the Mixl1 homeodomain protein in differentiating mouse embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

cis-regulatory region sequence-specific DNA binding

1 reference

9 May 2019

Pdgfrα and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

protein binding

1 reference

9 May 2019

Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

identical protein binding

1 reference

9 May 2019

Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

RNA polymerase II cis-regulatory region sequence-specific DNA binding

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

4 references

9 May 2019

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

DNA-binding transcription activator activity, RNA polymerase II-specific

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

12 references

10 September 2018

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

10 September 2018

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

10 September 2018

Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

10 September 2018

Pdgfrα and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

10 September 2018

Transcriptional activation by the Mixl1 homeodomain protein in differentiating mouse embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

7 November 2018

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

7 November 2018

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

7 November 2018

Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

7 November 2018

Transcriptional activation by the Mixl1 homeodomain protein in differentiating mouse embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

7 November 2018

Pdgfrα and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells.

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

protein homodimerization activity

5 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

27 March 2018

Ensembl genome database project

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

27 March 2018

Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

27 March 2018

Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

nucleus

6 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Ensembl genome database project

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

biological process

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

1 reference

9 May 2019

endoderm development

1 reference

9 May 2019

Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

1 reference

9 May 2019

endodermal cell differentiation

1 reference

9 May 2019

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

1 reference

27 March 2018

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

1 reference

9 May 2019

heart development

1 reference

9 May 2019

Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

positive regulation of mesoderm development

2 references

gastrulation

1 reference

9 May 2019

Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

hematopoietic progenitor cell differentiation

1 reference

9 May 2019

Transcriptional activation by the Mixl1 homeodomain protein in differentiating mouse embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

negative regulation of hematopoietic progenitor cell differentiation

1 reference

9 May 2019

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

cell migration involved in gastrulation

1 reference

9 May 2019

Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

digestive tract development

1 reference

9 May 2019

Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

endoderm formation

1 reference

9 May 2019

Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

positive regulation of transcription by RNA polymerase II

5 references

9 May 2019

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

Norwegian University of Science and Technology, Systems Biology team

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Pdgfrα and Flk1 are direct target genes of Mixl1 in differentiating embryonic stem cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Enforced expression of Mixl1 during mouse ES cell differentiation suppresses hematopoietic mesoderm and promotes endoderm formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Transcriptional activation by the Mixl1 homeodomain protein in differentiating mouse embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

9 May 2019

Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

transcription by RNA polymerase II

1 reference

27 March 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9WUI0&geneProductId=UniProtKB:Q9WUI0

hemopoiesis

1 reference

9 May 2019

Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

hematopoietic progenitor cell differentiation

hemopoiesis

endodermal cell differentiation

cell migration involved in gastrulation

negative regulation of hematopoietic progenitor cell differentiation

positive regulation of mesoderm development

Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

14 February 2019

Transcriptional activation by the Mixl1 homeodomain protein in differentiating mouse embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9WUI0

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9WUI0

Homeobox, conserved site

1 reference

InterPro Release 71.0