Thyroid hormone receptor alpha (Q21986929)

Zinc finger, NHR/GATA-type

1 reference

thyroid hormone receptor

1 reference

Nuclear hormone receptor, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, nuclear hormone receptor-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

14 February 2019

Characterization of a novel thyroid hormone receptor alpha variant involved in the regulation of myoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

steroid receptor RNA activator RNA binding

1 reference

24 April 2018

An RNA-binding domain in the thyroid hormone receptor enhances transcriptional activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

DNA-binding transcription factor activity

zinc ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

1 reference

14 February 2019

transcription cis-regulatory region binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

1 reference

14 February 2019

steroid hormone receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

1 reference

14 February 2019

nuclear receptor activity

1 reference

24 April 2018

TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

protein binding

4 references

14 February 2019

The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

chromatin DNA binding

1 reference

14 February 2019

Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

thyroid hormone binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

3 references

14 February 2019

ISS

14 February 2019

The c-erb-A gene encodes a thyroid hormone receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

protein-containing complex binding

1 reference

14 February 2019

Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

protein homodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

sequence-specific DNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

protein heterodimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

protein dimerization activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

transcription cis-regulatory region binding

RNA polymerase II transcription regulatory region sequence-specific DNA binding

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

single-stranded RNA binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

nuclear receptor activity

The T3R alpha gene encoding a thyroid hormone receptor is essential for post-natal development and thyroid hormone production

7 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

1 January 2018

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

1 January 2018

TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

transcription factor binding

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

nuclear receptor coactivator activity

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

signaling receptor activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

nuclear receptor activity

The T3R alpha gene encoding a thyroid hormone receptor is essential for post-natal development and thyroid hormone production

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

cell component

nucleus

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

24 April 2018

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

24 April 2018

Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

cytoplasm

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

24 April 2018

24 April 2018

Characterization of a novel thyroid hormone receptor alpha variant involved in the regulation of myoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

mitochondrion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

nucleus

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

RNA polymerase II transcription regulator complex

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

positive regulation of myotube differentiation

biological process

1 reference

24 April 2018

Characterization of a novel thyroid hormone receptor alpha variant involved in the regulation of myoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

regulation of myeloid cell apoptotic process

1 reference

14 February 2019

Erythroid defects in TRalpha-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

1 reference

14 February 2019

regulation of heart contraction

ossification

2 references

14 February 2019

The T3R alpha gene encoding a thyroid hormone receptor is essential for post-natal development and thyroid hormone production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

female courtship behavior

1 reference

14 February 2019

The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

cytoplasmic sequestering of transcription factor

1 reference

24 April 2018

Characterization of a novel thyroid hormone receptor alpha variant involved in the regulation of myoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

positive regulation of canonical Wnt signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

transcription, DNA-templated

IC

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

1 reference

24 April 2018

thyroid gland development

1 reference

24 April 2018

Congenital hypothyroid Pax8(-/-) mutant mice can be rescued by inactivating the TRalpha gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

regulation of lipid catabolic process

1 reference

14 February 2019

A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

type I pneumocyte differentiation

1 reference

24 April 2018

Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

learning or memory

1 reference

14 February 2019

Behavioral inhibition and impaired spatial learning and memory in hypothyroid mice lacking thyroid hormone receptor alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

animal organ morphogenesis

1 reference

24 April 2018

Different functions for the thyroid hormone receptors TRalpha and TRbeta in the control of thyroid hormone production and post-natal development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

response to cold

1 reference

14 February 2019

A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

erythrocyte differentiation

1 reference

14 February 2019

Erythroid defects in TRalpha-/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

negative regulation of transcription, DNA-templated

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

Mixed lineage kinase 2 enhances trans-repression of Alien and nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

cartilage condensation

1 reference

14 February 2019

The T3R alpha gene encoding a thyroid hormone receptor is essential for post-natal development and thyroid hormone production

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

positive regulation of female receptivity

1 reference

14 February 2019

The two thyroid hormone receptor genes have opposite effects on estrogen-stimulated sex behaviors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

regulation of thyroid hormone mediated signaling pathway

1 reference

14 February 2019

A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

steroid hormone mediated signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

intracellular receptor signaling pathway

1 reference

24 April 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

negative regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

positive regulation of transcription by RNA polymerase II

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

24 April 2018

Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?protein=P63058&geneProductId=UniProtKB:P63058

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

thyroid hormone mediated signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

multicellular organism development

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

brain development

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

hormone-mediated signaling pathway

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

animal organ morphogenesis

cell differentiation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

response to lipid

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

positive regulation of transcription by RNA polymerase II

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

type I pneumocyte differentiation

positive regulation of cold-induced thermogenesis

1 reference

14 February 2019

Type-2 iodothyronine 5'deiodinase (D2) in skeletal muscle of C57Bl/6 mice. II. Evidence for a role of D2 in the hypermetabolism of thyroid hormone receptor alpha-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P63058

Nuclear hormone receptor, ligand-binding domain

has part(s)

1 reference

nuclear hormone receptor-type zinc finger

1 reference