Signal-regulatory protein alpha (Q21986793)

Immunoglobulin-like domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Immunoglobulin subtype, protein family

1 reference

Immunoglobulin V-set domain, protein family

1 reference

Immunoglobulin C1-set, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Immunoglobulin/major histocompatibility complex, conserved site, protein family

1 reference

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

1 reference

14 February 2019

protein binding

3 references

14 February 2019

CMRF-35-like molecule-1, a novel mouse myeloid receptor, can inhibit osteoclast formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

14 February 2019

BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

14 February 2019

Tethering of apoptotic cells to phagocytes through binding of CD47 to Src homology 2 domain-bearing protein tyrosine phosphatase substrate-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

GTPase regulator activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

protein binding involved in heterotypic cell-cell adhesion

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

cell-cell adhesion mediator activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

protein antigen binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

protein tyrosine kinase binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

1 reference

14 February 2019

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97797&geneProductId=UniProtKB:P97797

1 reference

24 April 2018

integral component of plasma membrane

TAS

1 reference

24 April 2018

Tethering of apoptotic cells to phagocytes through binding of CD47 to Src homology 2 domain-bearing protein tyrosine phosphatase substrate-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97797&geneProductId=UniProtKB:P97797

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

1 reference

14 February 2019

cell surface

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

phagocytosis, recognition

biological process

1 reference

14 February 2019

Tethering of apoptotic cells to phagocytes through binding of CD47 to Src homology 2 domain-bearing protein tyrosine phosphatase substrate-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

positive regulation of phagocytosis

1 reference

24 April 2018

Tethering of apoptotic cells to phagocytes through binding of CD47 to Src homology 2 domain-bearing protein tyrosine phosphatase substrate-1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P97797&geneProductId=UniProtKB:P97797

phagocytosis, engulfment

1 reference

14 February 2019

Tethering of apoptotic cells to phagocytes through binding of CD47 to Src homology 2 domain-bearing protein tyrosine phosphatase substrate-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

cell-matrix adhesion

1 reference

14 February 2019

SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

cytoskeleton organization

1 reference

14 February 2019

SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

hematopoietic progenitor cell differentiation

1 reference

14 February 2019

Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

actin filament organization

1 reference

14 February 2019

SHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motility

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

cell migration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

negative regulation of protein phosphorylation

1 reference

14 February 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

regulation of gene expression

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

positive regulation of cell-cell adhesion

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

regulation of interferon-gamma production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

regulation of interleukin-1 beta production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

regulation of interleukin-6 production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

regulation of tumor necrosis factor production

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

negative regulation of interferon-beta production

1 reference

14 February 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

negative regulation of interleukin-6 production

1 reference

14 February 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

negative regulation of tumor necrosis factor production

1 reference

14 February 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

heterotypic cell-cell adhesion

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

monocyte extravasation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

negative regulation of nitric oxide biosynthetic process

1 reference

14 February 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

regulation of nitric oxide biosynthetic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

negative regulation of JNK cascade

1 reference

14 February 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

negative regulation of inflammatory response

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

positive regulation of phagocytosis

regulation of catalytic activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

positive regulation of T cell activation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

cellular response to hydrogen peroxide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

negative regulation of ERK1 and ERK2 cascade

1 reference

14 February 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

cellular response to lipopolysaccharide

1 reference

14 February 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

cellular response to interferon-gamma

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

cellular response to interleukin-1

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

cellular response to interleukin-12

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

negative regulation of macrophage inflammatory protein 1 alpha production

1 reference

14 February 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

negative regulation of chemokine (C-C motif) ligand 5 production

1 reference

14 February 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

granulocyte migration

IGI

1 reference

14 February 2019

Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

IGI

cell-cell adhesion

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

negative regulation of cytokine production involved in inflammatory response

IGI

negative regulation of I-kappaB phosphorylation

1 reference

14 February 2019

LPS-induced down-regulation of signal regulatory protein {alpha} contributes to innate immune activation in macrophages

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P97797

has part(s)

immunoglobulin subtype

1 reference

immunoglobulin V-set domain

1 reference

immunoglobulin-like domain

1 reference

immunoglobulin C1-set

1 reference

Immunoglobulin/major histocompatibility complex, conserved site

1 reference