Wingless-type MMTV integration site family, member 3A (Q21985642)

http://www.ebi.ac.uk/interpro/protein/P27467

Wnt protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

protein domain specific binding

1 reference

14 February 2019

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

signaling receptor binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

frizzled binding

1 reference

31 January 2017

Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P27467

receptor ligand activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

frizzled binding

1 reference

31 January 2017

Wnt5a regulates distinct signalling pathways by binding to Frizzled2

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P27467

protein binding

16 references

14 February 2019

Identification of key residues and regions important for porcupine-mediated Wnt acylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt3a binds to several sFRPs in the nanomolar range

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt3a binds to several sFRPs in the nanomolar range

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Identification of ptpro as a novel target gene of Wnt signaling and its potential role as a receptor for Wnt

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Tiki1 is required for head formation via Wnt cleavage-oxidation and inactivation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Characterization of a Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Structural Studies of Wnts and Identification of an LRP6 Binding Site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

transcription coactivator activity

1 reference

14 February 2019

Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

frizzled binding

Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt5a regulates distinct signalling pathways by binding to Frizzled2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

endoplasmic reticulum lumen

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

1 reference

14 February 2019

extracellular region

3 references

cell surface

1 reference

14 February 2019

Wnt family proteins are secreted and associated with the cell surface

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

Wnt signalosome

IC

NAS

extracellular space

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

synapse

1 reference

14 February 2019

Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

glutamatergic synapse

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Activity-dependent synaptic Wnt release regulates hippocampal long term potentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

EXP

biological process

somitogenesis

3 references

14 February 2019

Wnt3a links left-right determination with segmentation and anteroposterior axis elongation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt3a plays a major role in the segmentation clock controlling somitogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt-3a regulates somite and tailbud formation in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

hemopoiesis

1 reference

14 February 2019

A role for Wnt signalling in self-renewal of haematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of protein phosphorylation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

Wnt signaling pathway involved in forebrain neuroblast division

1 reference

14 February 2019

A local Wnt-3a signal is required for development of the mammalian hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of skeletal muscle tissue development

1 reference

14 February 2019

Beta-catenin is essential and sufficient for skeletal myogenesis in P19 cells

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

axis elongation involved in somitogenesis

1 reference

14 February 2019

An LDL-receptor-related protein mediates Wnt signalling in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of canonical Wnt signaling pathway

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt-10b, uniquely among Wnts, promotes epithelial differentiation and shaft growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of collateral sprouting in absence of injury

1 reference

14 February 2019

Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

mammary gland development

1 reference

14 February 2019

Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

platelet activation

1 reference

14 February 2019

Canonical Wnt signaling negatively regulates platelet function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

heart looping

1 reference

14 February 2019

Wnt3a links left-right determination with segmentation and anteroposterior axis elongation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

14 February 2019

Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of protein localization to plasma membrane

1 reference

14 February 2019

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

cardiac muscle cell fate commitment

1 reference

14 February 2019

AW551984: a novel regulator of cardiomyogenesis in pluripotent embryonic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

animal organ morphogenesis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

mesoderm development

1 reference

14 February 2019

Wnt-3a regulates somite and tailbud formation in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

cell proliferation in forebrain

1 reference

14 February 2019

Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

dopaminergic neuron differentiation

1 reference

14 February 2019

The role of Nurr1 in the development of dopaminergic neurons and Parkinson's disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

negative regulation of fat cell differentiation

Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

regulation of microtubule cytoskeleton organization

1 reference

14 February 2019

Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

negative regulation of dopaminergic neuron differentiation

1 reference

14 February 2019

Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

cell proliferation in midbrain

1 reference

14 February 2019

Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

in utero embryonic development

1 reference

14 February 2019

A re-examination of two skeletal mutants of the mouse, vestigial-tail (vt) and congenital hydrocephalus (ch)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

negative regulation of axon extension involved in axon guidance

1 reference

14 February 2019

Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of transcription, DNA-templated

3 references

14 February 2019

Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

A Role for WNT Proteins in Induction of Dermomyotome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2 -mobilization in Human Embryonic Kidney 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

regulation of axonogenesis

1 reference

14 February 2019

Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of B cell proliferation

1 reference

14 February 2019

Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

post-anal tail morphogenesis

1 reference

14 February 2019

Wnt-3a regulates somite and tailbud formation in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

negative regulation of neuron projection development

1 reference

14 February 2019

Wnt5a Controls Neurite Development in Olfactory Bulb Interneurons

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

paraxial mesodermal cell fate commitment

1 reference

14 February 2019

Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

negative regulation of neurogenesis

1 reference

14 February 2019

Wnt regulation of progenitor maturation in the cortex depends on Shh or fibroblast growth factor 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of protein tyrosine kinase activity

1 reference

14 February 2019

Dishevelled-2 docks and activates Src in a Wnt-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of DNA-binding transcription factor activity

1 reference

14 February 2019

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2 -mobilization in Human Embryonic Kidney 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

extracellular matrix organization

1 reference

14 February 2019

Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

BMP signaling pathway

1 reference

14 February 2019

A critical role for sFRP proteins in maintaining caudal neural tube closure in mice via inhibition of BMP signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of neural precursor cell proliferation

1 reference

14 February 2019

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

osteoblast differentiation

1 reference

14 February 2019

CCN1/Cyr61 is regulated by the canonical Wnt signal and plays an important role in Wnt3A-induced osteoblast differentiation of mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

skeletal muscle cell differentiation

1 reference

14 February 2019

BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

canonical Wnt signaling pathway

35 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

An LDL-receptor-related protein mediates Wnt signalling in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt5a regulates distinct signalling pathways by binding to Frizzled2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Characterization of mouse dishevelled (Dvl) proteins in Wnt/Wingless signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Dishevelled-2 docks and activates Src in a Wnt-dependent manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt signaling in heart valve development and osteogenic gene induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/β-catenin signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt signaling in heart valve development and osteogenic gene induction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt/Lrp/beta-catenin signaling suppresses adipogenesis by inhibiting mutual activation of PPARgamma and C/EBPalpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt3a binds to several sFRPs in the nanomolar range

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt and steroid pathways control glutamate signalling by regulating glutamine synthetase activity in osteoblastic cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Axin contains three separable domains that confer intramolecular, homodimeric, and heterodimeric interactions involved in distinct functions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2 -mobilization in Human Embryonic Kidney 293 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

COP9 signalosome assembly

1 reference

14 February 2019

Wnt induces LRP6 signalosomes and promotes dishevelled-dependent LRP6 phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

dorsal/ventral neural tube patterning

1 reference

14 February 2019

Wnt-3a regulates somite and tailbud formation in the mouse embryo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

platelet aggregation

1 reference

14 February 2019

Canonical Wnt signaling negatively regulates platelet function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

midbrain development

1 reference

14 February 2019

Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of protein kinase activity

1 reference

14 February 2019

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of cell-cell adhesion mediated by cadherin

1 reference

14 February 2019

Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of hepatocyte proliferation

1 reference

14 February 2019

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

neurogenesis

1 reference

14 February 2019

Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

spinal cord association neuron differentiation

positive regulation of cytokine production

1 reference

14 February 2019

Canonical and noncanonical Wnt proteins program dendritic cell responses for tolerance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

cell-cell signaling

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

somatic stem cell division

1 reference

14 February 2019

A role for Wnt signalling in self-renewal of haematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation

1 reference

14 February 2019

Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

axon guidance

1 reference

14 February 2019

Wnt regulates axon behavior through changes in microtubule growth directionality: a new role for adenomatous polyposis coli

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

determination of left/right symmetry

1 reference

14 February 2019

Wnt3a links left-right determination with segmentation and anteroposterior axis elongation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

inner ear morphogenesis

1 reference

14 February 2019

Wnt-dependent regulation of inner ear morphogenesis is balanced by the opposing and supporting roles of Shh.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of cell population proliferation

regulation of cell differentiation

1 reference

14 February 2019

A role for Wnt signalling in self-renewal of haematopoietic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

hippocampus development

1 reference

14 February 2019

A local Wnt-3a signal is required for development of the mammalian hippocampus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

signal transduction

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

anterior/posterior pattern specification

1 reference

14 February 2019

Anteriorization of neural fate by inhibitor of beta-catenin and T cell factor (ICAT), a negative regulator of Wnt signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

positive regulation of transcription by RNA polymerase II

Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells

7 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

BCL9 is an essential component of canonical Wnt signaling that mediates the differentiation of myogenic progenitors during muscle regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

calcium ion transmembrane transport via low voltage-gated calcium channel

1 reference

14 February 2019

LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P27467

6 references

31 January 2017

31 January 2017

An LDL-receptor-related protein mediates Wnt signalling in mice

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P27467

31 January 2017

Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P27467

31 January 2017

Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P27467

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P27467

31 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P27467

31 January 2017

negative regulation of canonical Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P27467

1 reference

31 January 2017

positive regulation of core promoter binding

1 reference

14 February 2019

Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

regulation of RNA biosynthetic process

1 reference

14 February 2019

mrhl RNA, a long noncoding RNA, negatively regulates Wnt signaling through its protein partner Ddx5/p68 in mouse spermatogonial cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

regulation of signaling receptor activity

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

Wnt signaling pathway

Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

14 February 2019

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

neuron differentiation

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

cell fate commitment

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

negative regulation of neuron death

1 reference

14 February 2019

Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P27467

Wnt protein, conserved site

has part(s)

1 reference

InterPro Release 71.0