Disabled 2, mitogen-responsive phosphoprotein (Q21982744)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P98078

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

PTB/PI domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

AP-2 adaptor complex binding

1 reference

9 May 2019

Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

clathrin binding

1 reference

9 May 2019

Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

integrin binding

1 reference

9 May 2019

Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

protein C-terminus binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

protein binding

13 references

9 May 2019

Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

Regulation of the Wnt signaling pathway by disabled-2 (Dab2)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

The NECAP PHear domain increases clathrin accessory protein binding potential

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

Dab2 links CIN85 with clathrin-mediated receptor internalization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

p67 isoform of mouse disabled 2 protein acts as a transcriptional activator during the differentiation of F9 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

Cloning and characterization of mouse disabled 2 interacting protein 2, a mouse orthologue of human NOSTRIN

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

Spatial regulation of VEGF receptor endocytosis in angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

Regulation of the Wnt signaling pathway by disabled-2 (Dab2)

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

phosphatidylinositol binding

1 reference

9 May 2019

Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

phosphatidylinositol-4,5-bisphosphate binding

1 reference

9 May 2019

Crystal structures of the Dab homology domains of mouse disabled 1 and 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

SMAD binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

clathrin coat of coated pit

cell component

1 reference

9 May 2019

Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

1 reference

9 May 2019

intracellular membrane-bounded organelle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

apical plasma membrane

1 reference

9 May 2019

The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

cytoplasmic vesicle

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

1 reference

9 May 2019

clathrin-coated vesicle

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

fibrillar center

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

perinuclear region of cytoplasm

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

1 reference

9 May 2019

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

1 reference

14 February 2019

plasma membrane

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

positive regulation of SMAD protein signal transduction

IBA

biological process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

cellular response to transforming growth factor beta stimulus

2 references

9 May 2019

Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

positive regulation of transforming growth factor beta receptor signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

1 reference

9 May 2019

myeloid cell differentiation

IEP

1 reference

9 May 2019

Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

positive regulation of protein phosphorylation

IEP

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

endoderm development

1 reference

24 April 2018

Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98078&geneProductId=UniProtKB:P98078

excretion

1 reference

9 May 2019

Dual roles for the Dab2 adaptor protein in embryonic development and kidney transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

1 reference

9 May 2019

positive regulation of receptor internalization

1 reference

9 May 2019

Spatial regulation of VEGF receptor endocytosis in angiogenesis

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

negative regulation of androgen receptor signaling pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

negative regulation of extrinsic apoptotic signaling pathway

1 reference

9 May 2019

Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

in utero embryonic development

1 reference

9 May 2019

Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

Wnt signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

1 reference

9 May 2019

negative regulation of protein binding

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

leading edge cell differentiation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

1 reference

9 May 2019

positive regulation of transcription, DNA-templated

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

positive regulation of endocytosis

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

protein transport

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

1 reference

9 May 2019

positive regulation of early endosome to late endosome transport

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

positive regulation of integrin-mediated signaling pathway

1 reference

9 May 2019

Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

pinocytosis

1 reference

24 April 2018

Endocytosis of megalin by visceral endoderm cells requires the Dab2 adaptor protein

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98078&geneProductId=UniProtKB:P98078

positive regulation of Wnt signaling pathway, planar cell polarity pathway

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

cell morphogenesis involved in differentiation

1 reference

9 May 2019

Disabled-2 is essential for endodermal cell positioning and structure formation during mouse embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

negative regulation of transcription, DNA-templated

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

negative regulation of canonical Wnt signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

positive regulation of transcription elongation from RNA polymerase II promoter

1 reference

9 May 2019

Disabled-2 (Dab2) mediates transforming growth factor beta (TGFbeta)-stimulated fibronectin synthesis through TGFbeta-activated kinase 1 and activation of the JNK pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

positive regulation of receptor recycling

1 reference

9 May 2019

Type II Transforming Growth Factor-β Receptor Recycling Is Dependent upon the Clathrin Adaptor Protein Dab2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

positive regulation of cell adhesion

apoptotic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

1 reference

9 May 2019

receptor-mediated endocytosis

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

negative regulation of neuron projection development

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

negative regulation of cell growth

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

positive regulation of aldosterone biosynthetic process

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

response to steroid hormone

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

negative regulation of epithelial cell proliferation

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

negative regulation of ERK1 and ERK2 cascade

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

cellular response to epidermal growth factor stimulus

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

positive regulation of substrate adhesion-dependent cell spreading

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

9 May 2019

Disabled-2 is transcriptionally regulated by ICSBP and augments macrophage spreading and adhesion.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

regulation of Rho-dependent protein serine/threonine kinase activity

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

positive regulation of aldosterone secretion

1 reference

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

receptor-mediated endocytosis

IBA

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98078

1 reference

InterPro Release 71.0