Protein arginine N-methyltransferase 5 (Q21981670)

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mammalian protein found in Mus musculus

protein arginine N-methyltransferase 5
Jak-binding protein 1
SKB1 homolog
shk1 kinase-binding protein 1 homolog
Prmt5
histone-arginine N-methyltransferase PRMT5

Language	Label	Description	Also known as
English	Protein arginine N-methyltransferase 5	mammalian protein found in Mus musculus	protein arginine N-methyltransferase 5 Jak-binding protein 1 SKB1 homolog shk1 kinase-binding protein 1 homolog Prmt5 histone-arginine N-methyltransferase PRMT5

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

S-adenosyl-L-methionine-dependent methyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIG8

Protein arginine N-methyltransferase PRMT5

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIG8

PRMT5, TIM barrel domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PRMT5 arginine-N-methyltransferase family

1 reference

based on heuristic

inferred from protein domain or family

PRMT5, oligomerisation domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

transcription corepressor activity

determination method or standard

1 reference

9 May 2019

Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

core promoter sequence-specific DNA binding

determination method or standard

1 reference

24 April 2018

Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIG8&geneProductId=UniProtKB:Q8CIG8

determination method or standard

ribonucleoprotein complex binding

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

transferase activity

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

chromatin binding

determination method or standard

1 reference

9 May 2019

The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

protein binding

determination method or standard

5 references

9 May 2019

The histone- and PRMT5-associated protein COPR5 is required for myogenic differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

Nuclear Cyclin D1/CDK4 Kinase Regulates CUL4 Expression and Triggers Neoplastic Growth via Activation of the PRMT5 Methyltransferase

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

Friend of Prmt1, a novel chromatin target of protein arginine methyltransferases

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

methyltransferase activity

determination method or standard

3 references

9 May 2019

Spliceosome Sm proteins D1, D3, and B/B' are asymmetrically dimethylated at arginine residues in the nucleus

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

protein heterodimerization activity

determination method or standard

1 reference

9 May 2019

Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

histone-arginine N-methyltransferase activity

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

identical protein binding

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

protein-containing complex binding

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

determination method or standard

1 reference

9 May 2019

Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

determination method or standard

3 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

determination method or standard

3 references

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

determination method or standard

5 references

5 June 2018

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIG8&geneProductId=UniProtKB:Q8CIG8

determination method or standard

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIG8&geneProductId=UniProtKB:Q8CIG8

determination method or standard

5 June 2018

Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIG8&geneProductId=UniProtKB:Q8CIG8

determination method or standard

5 June 2018

Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIG8&geneProductId=UniProtKB:Q8CIG8

determination method or standard

5 June 2018

Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIG8&geneProductId=UniProtKB:Q8CIG8

determination method or standard

Golgi apparatus

determination method or standard

histone methyltransferase complex

determination method or standard

2 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

protein-containing complex

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

determination method or standard

6 references

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

Transcription factor positive regulatory domain 4 (PRDM4) recruits protein arginine methyltransferase 5 (PRMT5) to mediate histone arginine methylation and control neural stem cell proliferation and differentiation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

biological process

histone H4-R3 methylation

determination method or standard

1 reference

9 May 2019

Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

rhythmic process

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIG8&geneProductId=UniProtKB:Q8CIG8

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIG8&geneProductId=UniProtKB:Q8CIG8

determination method or standard

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

1 reference

9 May 2019

The LIM protein AJUBA recruits protein arginine methyltransferase 5 to mediate SNAIL-dependent transcriptional repression

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

circadian regulation of gene expression

determination method or standard

1 reference

9 May 2019

Role of type II protein arginine methyltransferase 5 in the regulation of Circadian Per1 gene

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

endothelial cell activation

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

peptidyl-arginine methylation, to symmetrical-dimethyl arginine

determination method or standard

1 reference

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8CIG8&geneProductId=UniProtKB:Q8CIG8

determination method or standard

positive regulation of adenylate cyclase-inhibiting dopamine receptor signaling pathway

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

chromatin organization

determination method or standard

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

regulation of DNA methylation

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

negative regulation of cell differentiation

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

positive regulation of oligodendrocyte differentiation

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

regulation of ERK1 and ERK2 cascade

determination method or standard

1 reference

9 May 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

peptidyl-arginine methylation, to symmetrical-dimethyl arginine

determination method or standard

1 reference

9 May 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

histone arginine methylation

determination method or standard

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8CIG8

determination method or standard

PRMT5 arginine-N-methyltransferase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIG8

PRMT5, TIM barrel domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIG8

PRMT5, oligomerisation domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8CIG8

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000023873

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000023873

ENSMUSP00000121502

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000121502

ENSMUSP00000138549

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000138549

ENSMUSP00000154584

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000154584

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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