Frizzled class receptor 8 (Q21981588)

Frizzled cysteine-rich domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Frizzled/Smoothened, transmembrane domain, protein family

1 reference

inferred from protein domain or family

GPCR, family 2-like

1 reference

inferred from protein domain or family

Frizzled domain, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

11 references

14 February 2019

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Structural Studies of Wnts and Identification of an LRP6 Binding Site

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

4 references

24 April 2018

Structural basis of Wnt recognition by Frizzled

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

24 April 2018

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

24 April 2018

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

signal transducer activity

IPI

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

transmembrane signaling receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

signaling receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Identification of a PDZ domain containing Golgi protein, GOPC, as an interaction partner of frizzled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

Wnt-activated receptor activity

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

24 April 2018

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

G protein-coupled receptor activity

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

5 references

14 February 2019

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Structural basis of Wnt recognition by Frizzled

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

Wnt-activated receptor activity

IBA

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

2 references

Wnt-Frizzled-LRP5/6 complex

3 references

14 February 2019

Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

24 April 2018

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

integral component of membrane

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

integral component of membrane

IBA

T cell differentiation in thymus

2 references

biological process

1 reference

14 February 2019

Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

cell surface receptor signaling pathway

IMP

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

multicellular organism development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

G protein-coupled receptor signaling pathway

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

positive regulation of JUN kinase activity

1 reference

14 February 2019

MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

1 reference

14 February 2019

Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

negative regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

positive regulation of protein phosphorylation

1 reference

14 February 2019

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

positive regulation of transcription by RNA polymerase II

IMP

1 reference

14 February 2019

Sox17 is essential for the specification of cardiac mesoderm in embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

Wnt signaling pathway

3 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

canonical Wnt signaling pathway

7 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

24 April 2018

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

24 April 2018

Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

24 April 2018

Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

24 April 2018

Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

24 April 2018

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61091&geneProductId=UniProtKB:Q61091

non-canonical Wnt signaling pathway

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

canonical Wnt signaling pathway

IBA

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Truncated mutants of the putative Wnt receptor LRP6/Arrow can stabilize beta-catenin independently of Frizzled proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Wnt signaling is required for thymocyte development and activates Tcf-1 mediated transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61091

1 reference

GPCR, family 2-like

1 reference

Frizzled/Smoothened, transmembrane domain

1 reference