Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases (Q21562402)

25 August 2022

5

Gurdyal S Besra

Gurdyal S

Besra

1 reference

25 August 2022

Alistair K Brown

1

Alistair K

Brown

1 reference

25 August 2022

Rebecca C Taylor

series ordinal

2

author given names

Rebecca C

author last names

Taylor

1 reference

25 August 2022

Apoorva Bhatt

series ordinal

3

author given names

Apoorva

author last names

Bhatt

1 reference

Creative Commons Attribution 4.0 International

25 August 2022

language of work or name

English

0 references

publication date

2009

0 references

published in

PLOS One

0 references

volume

4

0 references

issue

7

0 references

page(s)

e6306

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copyright license

start time

17 July 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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19 March 2017

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19 March 2017

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Acyl-CoA carboxylases (accD2 and accD3), together with a unique polyketide synthase (Cg-pks), are key to mycolic acid biosynthesis in Corynebacterianeae such as Corynebacterium glutamicum and Mycobacterium tuberculosis

19 March 2017

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Mycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosis

19 March 2017

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Purification and biochemical characterization of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthases KasA and KasB

19 March 2017

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Activation of the pro-drug ethionamide is regulated in mycobacteria

19 March 2017

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Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis

19 March 2017

1 reference

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Identification and substrate specificity of beta -ketoacyl (acyl carrier protein) synthase III (mtFabH) from Mycobacterium tuberculosis

19 March 2017

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Thiolactomycin and related analogues as novel anti-mycobacterial agents targeting KasA and KasB condensing enzymes in Mycobacterium tuberculosis

19 March 2017

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The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance

19 March 2017

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Rapid, Low-Technology MIC Determination with Clinical Mycobacterium tuberculosis Isolates by Using the Microplate Alamar Blue Assay

19 March 2017

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Antimycobacterial action of thiolactomycin: an inhibitor of fatty acid and mycolic acid synthesis

19 March 2017

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Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis

19 March 2017

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Specialized transduction: an efficient method for generating marked and unmarked targeted gene disruptions in Mycobacterium tuberculosis, M. bovis BCG and M. smegmatis

19 March 2017

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inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis

7 April 2017

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Functional complementation of the essential gene fabG1 of Mycobacterium tuberculosis by Mycobacterium smegmatis fabG but not Escherichia coli fabG

7 April 2017

1 reference

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Platensimycin is a selective FabF inhibitor with potent antibiotic properties

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707616

Probing the mechanism of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III mtFabH: factors influencing catalysis and substrate specificity

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707616

A polyketide synthase catalyzes the last condensation step of mycolic acid biosynthesis in mycobacteria and related organisms

12 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2707616

Requirement for kasB in Mycobacterium mycolic acid biosynthesis, cell wall impermeability and intracellular survival: implications for therapy

12 September 2017

1 reference

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Conditional depletion of KasA, a key enzyme of mycolic acid biosynthesis, leads to mycobacterial cell lysis.

12 September 2017

1 reference

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Tuberculosis control: the relevance of classic principles in an era of acquired immunodeficiency syndrome and multidrug resistance

27 September 2017

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Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis

27 September 2017

1 reference

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Identification of the dehydratase component of the mycobacterial mycolic acid-synthesizing fatty acid synthase-II complex

30 May 2018

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Flavonoid inhibitors as novel antimycobacterial agents targeting Rv0636, a putative dehydratase enzyme involved in Mycobacterium tuberculosis fatty acid synthase II.

29 November 2018

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Two functional FAS-I type fatty acid synthases in Corynebacterium glutamicum

29 November 2018

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Temperature-induced changes in the cell-wall components of Mycobacterium thermoresistibile

29 November 2018

1 reference

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Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strategy

29 November 2018

1 reference

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0006306

1 reference

ADS bibcode

2009PLoSO...4.6306B

0 references

1 reference

1 reference

1 reference