Retinoid X receptor alpha (Q21499097)

Zinc finger, NHR/GATA-type

1 reference

Nuclear hormone receptor-like domain superfamily

1 reference

Nuclear hormone receptor, ligand-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Zinc finger, nuclear hormone receptor-type, protein family

1 reference

based on heuristic

inferred from protein domain or family

Nuclear/hormone receptor activator site AF-1, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

sequence-specific DNA binding

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

DNA binding

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

The gene encoding the Acyl-CoA-binding protein is activated by peroxisome proliferator-activated receptor gamma through an intronic response element functionally conserved between humans and rodents

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

NF-Y is essential for the recruitment of RNA polymerase II and inducible transcription of several CCAAT box-containing genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

protein heterodimerization activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

nuclear receptor activity

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

nuclear receptor activity

1 reference

7 November 2018

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28700&geneProductId=UniProtKB:P28700

chromatin DNA binding

1 reference

14 February 2019

Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

steroid hormone receptor activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

1 reference

14 February 2019

protein binding

12 references

14 February 2019

Molecular cloning and characterization of a novel inhibitor of apoptosis protein from Xenopus laevis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Differential ligand-dependent interactions between the AF-2 activating domain of nuclear receptors and the putative transcriptional intermediary factors mSUG1 and TIF1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

TGIF inhibits retinoid signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Identification of a novel nurr1-interacting protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

PSF is a novel corepressor that mediates its effect through Sin3A and the DNA binding domain of nuclear hormone receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

DNA-binding transcription factor activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

transcription factor binding

1 reference

14 February 2019

MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

1 reference

14 February 2019

zinc ion binding

protein domain specific binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

retinoic acid receptor binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

protein-containing complex binding

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

cell component

nucleus

6 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Neurological defects in trichothiodystrophy reveal a coactivator function of TFIIH

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Cyclo-oxygenase-2-derived prostacyclin mediates embryo implantation in the mouse via PPARdelta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

1 reference

14 February 2019

RNA polymerase II transcription regulator complex

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

axon

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

negative regulation of gene expression

biological process

1 reference

14 February 2019

Epicardial-myocardial signaling directing coronary vasculogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

ventricular cardiac muscle tissue morphogenesis

1 reference

14 February 2019

Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

positive regulation of translational initiation by iron

1 reference

14 February 2019

The corepressor CTBP2 is a coactivator of retinoic acid receptor/retinoid X receptor in retinoic acid signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

1 reference

24 April 2018

Two novel RXR alpha isoforms from mouse testis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28700&geneProductId=UniProtKB:P28700

regulation of transcription by RNA polymerase II

1 reference

14 February 2019

Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

cardiac muscle cell proliferation

Epicardial-myocardial signaling directing coronary vasculogenesis

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

in utero embryonic development

1 reference

14 February 2019

Retinoid X receptors are essential for early mouse development and placentogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

regulation of branching involved in prostate gland morphogenesis

1 reference

14 February 2019

Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor alpha allele in the prostate epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

steroid hormone mediated signaling pathway

1 reference

14 February 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

heart morphogenesis

1 reference

14 February 2019

Epicardial-myocardial signaling directing coronary vasculogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

ventricular cardiac muscle cell differentiation

Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes

2 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Vitamin A deficiency and mutations of RXRalpha, RXRbeta and RARalpha lead to early differentiation of embryonic ventricular cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

positive regulation of transcription, DNA-templated

2 references

mesenchyme development

1 reference

14 February 2019

Epicardial-myocardial signaling directing coronary vasculogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

heart development

positive regulation of transcription by RNA polymerase II

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

The corepressor CTBP2 is a coactivator of retinoic acid receptor/retinoid X receptor in retinoic acid signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

TGIF inhibits retinoid signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

EBF2 determines and maintains brown adipocyte identity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Retinoic acid, hypoxia, and GATA factors cooperatively control the onset of fetal liver erythropoietin expression and erythropoietic differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

TGIF inhibits retinoid signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

The liver X receptor (LXR) and hepatic lipogenesis. The carbohydrate-response element-binding protein is a target gene of LXR

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

cardiac muscle cell differentiation

1 reference

14 February 2019

Epicardial-myocardial signaling directing coronary vasculogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

maternal placenta development

1 reference

14 February 2019

Retinoid X receptors are essential for early mouse development and placentogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

angiogenesis involved in coronary vascular morphogenesis

1 reference

14 February 2019

Epicardial-myocardial signaling directing coronary vasculogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

retinoic acid receptor signaling pathway

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

The corepressor CTBP2 is a coactivator of retinoic acid receptor/retinoid X receptor in retinoic acid signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

visceral serous pericardium development

1 reference

14 February 2019

Epicardial-myocardial signaling directing coronary vasculogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

negative regulation of transcription by RNA polymerase II

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

Thyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndrome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development

1 reference

14 February 2019

Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor alpha allele in the prostate epithelium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

embryo implantation

1 reference

14 February 2019

Retinoid X receptors are essential for early mouse development and placentogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

camera-type eye development

1 reference

14 February 2019

Limited specificity and large overlap of the functions of the mouse RARγ1 and RARγ2 isoforms

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P28700&geneProductId=UniProtKB:P28700

1 reference

24 April 2018

placenta development

1 reference

14 February 2019

Defects of the Chorioallantoic Placenta in Mouse RXRα Null Fetuses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

regulation of transcription, DNA-templated

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

14 February 2019

14 February 2019

TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

negative regulation of cell population proliferation

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

regulation of myelination

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

positive regulation of apoptotic process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

response to glucocorticoid

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P28700

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

1051

English

Nuclear/hormone receptor activator site AF-1

17 August 2016

has part(s)

1 reference

Nuclear hormone receptor, ligand-binding domain

1 reference

nuclear hormone receptor-type zinc finger

1 reference

Identifiers

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

20 March 2022

1 reference

25 May 2022

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016