Yes-associated protein 1 (Q21498262)

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mammalian protein found in Mus musculus
  • yes-associated protein, 65 kDa
  • protein yorkie homolog
  • transcriptional coactivator YAP1
  • Yap1
  • yes-associated protein YAP65 homolog
  • 65 kDa Yes-associated protein
  • yorkie homolog
edit
Language Label Description Also known as
English
Yes-associated protein 1
mammalian protein found in Mus musculus
  • yes-associated protein, 65 kDa
  • protein yorkie homolog
  • transcriptional coactivator YAP1
  • Yap1
  • yes-associated protein YAP65 homolog
  • 65 kDa Yes-associated protein
  • yorkie homolog

Statements

molecular function
protein binding
determination method or standard
IPI
11 references
retrieved
9 May 2019
stated in
A WW domain protein TAZ is a critical coactivator for TBX5, a transcription factor implicated in Holt-Oram syndrome
GOA
curator
UniProt
UniProt protein ID
P46938
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IPI
retrieved
9 May 2019
stated in
Hippo Pathway Inhibits Wnt Signaling to Restrain Cardiomyocyte Proliferation and Heart Size
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IPI
retrieved
9 May 2019
stated in
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IPI
retrieved
9 May 2019
stated in
Regulation of mouse embryonic stem cell self-renewal by a Yes–YAP–TEAD2 signaling pathway downstream of LIF
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IPI
retrieved
9 May 2019
stated in
YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IPI
retrieved
9 May 2019
stated in
Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IPI
retrieved
9 May 2019
stated in
Yap1 acts downstream of α-catenin to control epidermal proliferation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IPI
retrieved
9 May 2019
stated in
Physical interaction with Yes-associated protein enhances p73 transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IPI
retrieved
9 May 2019
stated in
Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IPI
retrieved
9 May 2019
stated in
Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IPI
retrieved
9 May 2019
stated in
Hippo signaling regulates microprocessor and links cell-density-dependent miRNA biogenesis to cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IPI
cell component
cytoplasm
determination method or standard
IDA
IEA
ISO
11 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P46938
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IEA
retrieved
14 February 2019
stated in
Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
A crucial role of WW45 in developing epithelial tissues in the mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
nucleus
determination method or standard
IDA
IEA
ISO
15 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
ISO
retrieved
14 February 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P46938
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IEA
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IEA
retrieved
14 February 2019
stated in
DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2
GOA
curator
UniProt
UniProt protein ID
P46938
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
A crucial role of WW45 in developing epithelial tissues in the mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
Regulation of mouse embryonic stem cell self-renewal by a Yes–YAP–TEAD2 signaling pathway downstream of LIF
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
14 February 2019
stated in
Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
nucleus
determination method or standard
IBA
IDA
IEA
ISO
16 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P46938
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IEA
retrieved
9 May 2019
stated in
DLG5 connects cell polarity and Hippo signaling protein networks by linking PAR-1 with MST1/2
GOA
curator
UniProt
UniProt protein ID
P46938
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
A crucial role of WW45 in developing epithelial tissues in the mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
Tumor suppressor Nf2 limits expansion of the neural progenitor pool by inhibiting Yap/Taz transcriptional coactivators
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
Regulation of mouse embryonic stem cell self-renewal by a Yes–YAP–TEAD2 signaling pathway downstream of LIF
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IBA
cytoplasm
determination method or standard
IBA
IDA
IEA
ISO
12 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
ISO
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P46938
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IEA
retrieved
9 May 2019
stated in
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH, and hippo pathway effectors by Notch1
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
Nf2-Yap signaling controls the expansion of DRG progenitors and glia during DRG development
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
Temporal reduction of LATS kinases in the early preimplantation embryo prevents ICM lineage differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
A crucial role of WW45 in developing epithelial tissues in the mouse
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
The hippo pathway effector Yap controls patterning and differentiation of airway epithelial progenitors
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
Stromal-epithelial crosstalk regulates kidney progenitor cell differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IBA
biological process
positive regulation of transcription by RNA polymerase II
determination method or standard
IBA
IDA
IEA
IGI
ISO
6 references
retrieved
9 May 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
ISO
retrieved
9 May 2019
stated in
Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IGI
retrieved
9 May 2019
stated in
Regulation of mouse embryonic stem cell self-renewal by a Yes–YAP–TEAD2 signaling pathway downstream of LIF
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IGI
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IEA
retrieved
9 May 2019
stated in
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P46938
determination method or standard
IBA

Identifiers

 
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