Catenin (cadherin associated protein), alpha 2 (Q21498228)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q61301

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Vinculin, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

structural molecule activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

1 reference

14 February 2019

actin filament binding

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q61301&geneProductId=UniProtKB:Q61301

1 reference

1 January 2018

identical protein binding

IPI

1 reference

14 February 2019

Monomeric α-catenin links cadherin to the actin cytoskeleton

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

IPI

cadherin binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

1 reference

14 February 2019

actin filament binding

actin filament binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

14 February 2019

Ensembl genome database project

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

cell component

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

4 references

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

14 February 2019

Ensembl genome database project

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

1 reference

14 February 2019

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

1 reference

14 February 2019

adherens junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

4 references

14 February 2019

14 February 2019

Differential expression of alpha-E-catenin and alpha-N-catenin in the developing cerebral cortex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

14 February 2019

NF2deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

14 February 2019

Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

1 reference

14 February 2019

cell junction

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

1 reference

14 February 2019

basolateral plasma membrane

1 reference

14 February 2019

Nuclear localization of beta-catenin and loss of apical brush border actin in cystic tubules of bcl-2 -/- mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

actin cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

1 reference

14 February 2019

cytoskeleton

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

1 reference

14 February 2019

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

1 reference

14 February 2019

lamellipodium

1 reference

14 February 2019

Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

postsynaptic density

1 reference

14 February 2019

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

hippocampal mossy fiber to CA3 synapse

1 reference

14 February 2019

The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

parallel fiber to Purkinje cell synapse

1 reference

14 February 2019

The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

presynaptic active zone cytoplasmic component

1 reference

14 February 2019

The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

extrinsic component of presynaptic membrane

1 reference

14 February 2019

The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

extrinsic component of postsynaptic membrane

1 reference

14 February 2019

The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

postsynaptic density, intracellular component

1 reference

14 February 2019

The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

biological process

cell differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

1 reference

14 February 2019

regulation of synapse structural plasticity

1 reference

14 February 2019

Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

axonogenesis

1 reference

14 February 2019

Alpha N-catenin deficiency causes defects in axon migration and nuclear organization in restricted regions of the mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

dendrite morphogenesis

1 reference

14 February 2019

Cadherin regulates dendritic spine morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

multicellular organism development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

1 reference

14 February 2019

radial glia guided migration of Purkinje cell

brain morphogenesis

Deletion in Catna2, encoding alpha N-catenin, causes cerebellar and hippocampal lamination defects and impaired startle modulation

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

14 February 2019

Alpha N-catenin deficiency causes defects in axon migration and nuclear organization in restricted regions of the mouse brain

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

14 February 2019

prepulse inhibition

1 reference

14 February 2019

Deletion in Catna2, encoding alpha N-catenin, causes cerebellar and hippocampal lamination defects and impaired startle modulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

cell-cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

1 reference

14 February 2019

modification of postsynaptic actin cytoskeleton

Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

14 February 2019

Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

14 February 2019

Stability of dendritic spines and synaptic contacts is controlled by alpha N-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q61301

regulation of neuron projection development

EXP

ISO

negative regulation of Arp2/3 complex-mediated actin nucleation

ISO

regulation of neuron migration

Vinculin, conserved site

1 reference

InterPro Release 71.0