Zinc metallopeptidase, STE24 (Q21497801)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q80W54

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Peptidase M48 family

1 reference

based on heuristic

inferred from protein domain or family

CAAX prenyl protease 1, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

metalloendopeptidase activity

3 references

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80W54&geneProductId=UniProtKB:Q80W54

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80W54&geneProductId=UniProtKB:Q80W54

31 January 2018

31 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q80W54&geneProductId=UniProtKB:Q80W54

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

1 reference

14 February 2019

metallopeptidase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

1 reference

14 February 2019

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

1 reference

14 February 2019

double-stranded DNA binding

1 reference

14 February 2019

Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

endopeptidase activity

1 reference

14 February 2019

HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

metalloendopeptidase activity

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

integral component of membrane

IBA

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

1 reference

14 February 2019

nuclear inner membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

1 reference

14 February 2019

endoplasmic reticulum membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

1 reference

14 February 2019

endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

1 reference

14 February 2019

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

1 reference

14 February 2019

integral component of endoplasmic reticulum membrane

IBA

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

IBA

nuclear envelope

1 reference

14 February 2019

Genomic instability in laminopathy-based premature aging

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

prenylated protein catabolic process

biological process

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

nuclear envelope organization

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

liver development

1 reference

14 February 2019

Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

hair follicle development

1 reference

14 February 2019

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

heart morphogenesis

1 reference

14 February 2019

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

ventricular cardiac muscle tissue development

1 reference

14 February 2019

Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

cardiac ventricle development

1 reference

14 February 2019

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

growth plate cartilage development

1 reference

14 February 2019

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

DNA repair

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Genomic instability in laminopathy-based premature aging

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

chromatin organization

1 reference

14 February 2019

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of transcription, DNA-templated

1 reference

14 February 2019

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

inflammatory cell apoptotic process

1 reference

14 February 2019

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

cellular response to DNA damage stimulus

3 references

14 February 2019

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Genomic instability in laminopathy-based premature aging

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

nucleus organization

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Prelamin A and lamin A appear to be dispensable in the nuclear lamina

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of mitotic cell cycle

1 reference

14 February 2019

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

adult walking behavior

1 reference

14 February 2019

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of heart contraction

1 reference

14 February 2019

Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

determination of adult lifespan

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

9 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Genomic instability in laminopathy-based premature aging

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of cell shape

1 reference

14 February 2019

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

epidermis development

1 reference

14 February 2019

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of autophagy

1 reference

14 February 2019

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

positive regulation of gene expression

1 reference

14 February 2019

Cartilage oligomeric matrix protein prevents vascular aging and vascular smooth muscle cells senescence

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

negative regulation of gene expression

regulation of glucose metabolic process

1 reference

14 February 2019

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

protein processing

1 reference

14 February 2019

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of lipid metabolic process

1 reference

14 February 2019

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

bone mineralization

1 reference

14 February 2019

Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of bone mineralization

1 reference

14 February 2019

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of TOR signaling

1 reference

14 February 2019

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of hormone metabolic process

1 reference

14 February 2019

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

multicellular organism growth

regulation of multicellular organism growth

1 reference

14 February 2019

Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

maintenance of rDNA

1 reference

14 February 2019

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of DNA damage response, signal transduction by p53 class mediator

histone H2B acetylation

1 reference

14 February 2019

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

histone H2B-K5 acetylation

1 reference

14 February 2019

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

hypomethylation of CpG island

1 reference

14 February 2019

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of DNA methylation

1 reference

14 February 2019

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

cellular lipid metabolic process

1 reference

14 February 2019

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of fibroblast proliferation

1 reference

14 February 2019

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

thymus development

1 reference

14 February 2019

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of defense response to virus

ZMPSTE24 defends against influenza and other pathogenic viruses

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

ISO

14 February 2019

ZMPSTE24 defends against influenza and other pathogenic viruses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

Ensembl genome database project

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

neuromuscular process

chromosome organization

1 reference

14 February 2019

Genomic instability in laminopathy-based premature aging

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of ventricular cardiac muscle cell membrane repolarization

1 reference

14 February 2019

Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

kidney morphogenesis

1 reference

14 February 2019

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

cardiac conduction

1 reference

14 February 2019

Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

CAMKK-AMPK signaling cascade

1 reference

14 February 2019

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of stress-activated protein kinase signaling cascade

1 reference

14 February 2019

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

cellular response to gamma radiation

1 reference

14 February 2019

Genomic instability in laminopathy-based premature aging

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

response to DNA damage checkpoint signaling

1 reference

14 February 2019

Genomic instability in laminopathy-based premature aging

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of histone H4 acetylation

1 reference

14 February 2019

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of RNA polymerase II regulatory region sequence-specific DNA binding

1 reference

14 February 2019

Genomic instability in laminopathy-based premature aging

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of mitotic cell cycle DNA replication

1 reference

14 February 2019

Genomic instability in laminopathy-based premature aging

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of blood circulation

1 reference

14 February 2019

Premature aging in mice activates a systemic metabolic response involving autophagy induction.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

negative regulation of production of miRNAs involved in gene silencing by miRNA

calcium ion import into sarcoplasmic reticulum

1 reference

14 February 2019

Cardiac electrical defects in progeroid mice and Hutchinson-Gilford progeria syndrome patients with nuclear lamina alterations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of histone H4-K16 acetylation

1 reference

14 February 2019

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of termination of RNA polymerase I transcription

1 reference

14 February 2019

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

regulation of cellular senescence

Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

14 February 2019

Targeting isoprenylcysteine methylation ameliorates disease in a mouse model of progeria.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q80W54

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q80W54

CAAX prenyl protease 1, N-terminal

1 reference

InterPro Release 71.0