TNF receptor-associated factor 6 (Q21497539)

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mammalian protein found in Mus musculus
  • E3 ubiquitin-protein ligase TRAF6
  • RING-type E3 ubiquitin transferase TRAF6
  • Traf6
edit
Language Label Description Also known as
English
TNF receptor-associated factor 6
mammalian protein found in Mus musculus
  • E3 ubiquitin-protein ligase TRAF6
  • RING-type E3 ubiquitin transferase TRAF6
  • Traf6

Statements

molecular function
protein binding
determination method or standard
IPI
25 references
retrieved
14 February 2019
stated in
FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway
GOA
curator
UniProt
UniProt protein ID
P70196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development
GOA
curator
UniProt
UniProt protein ID
P70196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
Antiviral protein Viperin promotes Toll-like receptor 7- and Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells
GOA
curator
UniProt
UniProt protein ID
P70196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
GOA
curator
UniProt
UniProt protein ID
P70196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
Identification of MEKK2/3 serine phosphorylation site targeted by the Toll-like receptor and stress pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
Hsp70 inhibits lipopolysaccharide-induced NF-kappaB activation by interacting with TRAF6 and inhibiting its ubiquitination
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
NF-kappaB activator Act1 associates with IL-1/Toll pathway adaptor molecule TRAF6
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
Identification of TRAF6, a novel tumor necrosis factor receptor-associated factor protein that mediates signaling from an amino-terminal domain of the CD40 cytoplasmic region
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
The orphan nuclear receptor SHP acts as a negative regulator in inflammatory signaling triggered by Toll-like receptors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
Bioinformatics and cellular signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
Identification of TIFA as an adapter protein that links tumor necrosis factor receptor-associated factor 6 (TRAF6) to interleukin-1 (IL-1) receptor-associated kinase-1 (IRAK-1) in IL-1 receptor signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
A20-binding inhibitor of NF-κB (ABIN1) controls Toll-like receptor-mediated CCAAT/enhancer-binding protein β activation and protects from inflammatory disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
retrieved
14 February 2019
stated in
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IPI
cell component
biological process
positive regulation of I-kappaB kinase/NF-kappaB signaling
determination method or standard
IGI
IEA
IMP
ISO
5 references
retrieved
24 April 2018
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70196&geneProductId=UniProtKB:P70196
determination method or standard
ISO
retrieved
24 April 2018
stated in
Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling
GOA
curator
UniProt
UniProt protein ID
P70196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70196&geneProductId=UniProtKB:P70196
determination method or standard
IMP
retrieved
24 April 2018
stated in
Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling
GOA
curator
UniProt
UniProt protein ID
P70196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70196&geneProductId=UniProtKB:P70196
determination method or standard
IMP
retrieved
24 April 2018
stated in
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70196&geneProductId=UniProtKB:P70196
determination method or standard
IGI
retrieved
24 April 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P70196&geneProductId=UniProtKB:P70196
determination method or standard
IEA
positive regulation of I-kappaB kinase/NF-kappaB signaling
determination method or standard
IBA
IEA
IGI
IMP
ISO
6 references
retrieved
14 February 2019
stated in
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
ISO
retrieved
14 February 2019
stated in
Cutting edge: TNFR-associated factor (TRAF) 6 is essential for MyD88-dependent pathway but not toll/IL-1 receptor domain-containing adaptor-inducing IFN-beta (TRIF)-dependent pathway in TLR signaling
GOA
curator
UniProt
UniProt protein ID
P70196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IMP
retrieved
14 February 2019
stated in
Human lactoferrin activates NF-kappaB through the Toll-like receptor 4 pathway while it interferes with the lipopolysaccharide-stimulated TLR4 signaling
GOA
curator
UniProt
UniProt protein ID
P70196
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IMP
retrieved
14 February 2019
stated in
The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IGI
retrieved
14 February 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IEA
retrieved
14 February 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P70196
determination method or standard
IBA

Identifiers

 
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