BCL2-antagonist/killer 1 (Q21497080)

Apoptosis regulator BAK

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Apoptosis regulator, Bcl-2, BH3 motif, conserved site, protein family

1 reference

inferred from protein domain or family

Apoptosis regulator, Bcl-2, BH1 motif, conserved site, protein family

1 reference

inferred from protein domain or family

Apoptosis regulator, Bcl-2, BH2 motif, conserved site, protein family

1 reference

inferred from protein domain or family

1 reference

25 May 2022

1 reference

25 May 2022

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

1 reference

14 February 2019

protein binding

9 references

14 February 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

IL-6 protects against hyperoxia-induced mitochondrial damage via Bcl-2-induced Bak interactions with mitofusins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

VDAC2 inhibits BAK activation and mitochondrial apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Structural plasticity underpins promiscuous binding of the prosurvival protein A1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

BH3 domains other than Bim and Bid can directly activate Bax/Bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

BH domain binding

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

chaperone binding

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

heat shock protein binding

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

protein heterodimerization activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

protein homodimerization activity

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

integral component of membrane

cell component

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

1 reference

14 February 2019

integral component of mitochondrial outer membrane

1 reference

14 February 2019

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

intracellular anatomical structure

1 reference

10 October 2017

Pro- and anti-apoptotic members of the Bcl-2 family in skeletal muscle: a distinct role for Bcl-2 in later stages of myogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

endoplasmic reticulum

1 reference

14 February 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

mitochondrion

HUGO Gene Nomenclature Committee

8 references

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

Role of Bax and Bak in mitochondrial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

pore complex

HUGO Gene Nomenclature Committee

8 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Role of Bax and Bak in mitochondrial morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Temporal profiles of the subcellular localization of Bim, a BH3-only protein, during middle cerebral artery occlusion in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

A mitochondrial protein compendium elucidates complex I disease biology

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

mitochondrial outer membrane

HDA

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

cytosol

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

membrane

mitochondrial membranes

1 reference

14 February 2019

Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

biological process

leukocyte homeostasis

regulation of apoptotic process

2 references

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

1 reference

14 February 2019

establishment or maintenance of transmembrane electrochemical gradient

1 reference

14 February 2019

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

positive regulation of calcium ion transport into cytosol

1 reference

14 February 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

B cell apoptotic process

1 reference

14 February 2019

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

homeostasis of number of cells

1 reference

14 February 2019

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

response to organic cyclic compound

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

vagina development

1 reference

14 February 2019

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

cellular response to UV

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

myeloid cell homeostasis

1 reference

14 February 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

post-embryonic camera-type eye morphogenesis

1 reference

14 February 2019

Persistent fetal ocular vasculature in mice deficient in bax and bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

human ageing

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

B cell homeostasis

thymocyte apoptotic process

1 reference

14 February 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

regulation of cell cycle

1 reference

14 February 2019

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

regulation of mitochondrial membrane potential

ISS

cellular response to mechanical stimulus

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

blood vessel remodeling

1 reference

14 February 2019

Persistent fetal ocular vasculature in mice deficient in bax and bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

response to fungus

1 reference

14 February 2019

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

regulation of mitochondrial membrane permeability

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

fibroblast apoptotic process

1 reference

14 February 2019

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

apoptotic process involved in blood vessel morphogenesis

1 reference

14 February 2019

Persistent fetal ocular vasculature in mice deficient in bax and bak

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c

1 reference

14 February 2019

Bax and Bak independently promote cytochrome C release from mitochondria

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

animal organ regeneration

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

intrinsic apoptotic signaling pathway in response to DNA damage

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

3 references

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

10 October 2017

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

negative regulation of peptidyl-serine phosphorylation

1 reference

14 February 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

positive regulation of apoptotic process

5 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

extrinsic apoptotic signaling pathway in absence of ligand

negative regulation of endoplasmic reticulum calcium ion concentration

1 reference

14 February 2019

Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

cell population proliferation

1 reference

14 February 2019

Expression of Bcl-2 family during liver regeneration and identification of Bcl-x as a delayed early response gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

response to ethanol

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

activation of cysteine-type endopeptidase activity involved in apoptotic process

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Proapoptotic BAX and BAK control multiple initiator caspases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

response to gamma radiation

1 reference

14 February 2019

Radiation-induced gastric epithelial apoptosis occurs in the proliferative zone and is regulated by p53, bak, bax, and bcl-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

response to UV-C

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

response to hydrogen peroxide

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

endocrine pancreas development

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

release of cytochrome c from mitochondria

HUGO Gene Nomenclature Committee

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

B cell negative selection

1 reference

14 February 2019

Essential role of BAX,BAK in B cell homeostasis and prevention of autoimmune disease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

response to mycotoxin

1 reference

14 February 2019

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

negative regulation of cell population proliferation

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

positive regulation of release of cytochrome c from mitochondria

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

negative regulation of gene expression

1 reference

10 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O08734&geneProductId=UniProtKB:O08734

apoptotic process

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

intrinsic apoptotic signaling pathway in response to DNA damage

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

4 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

viral process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

1 reference

14 February 2019

extrinsic apoptotic signaling pathway in absence of ligand

Combined loss of proapoptotic genes Bak or Bax with Bim synergizes to cause defects in hematopoiesis and in thymocyte apoptosis

3 references

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08734

Apoptosis regulator, Bcl-2, BH3 motif, conserved site

has part(s)

1 reference

Apoptosis regulator, Bcl-2, BH1 motif, conserved site

1 reference

Apoptosis regulator, Bcl-2, BH2 motif, conserved site

1 reference