Phosphoinositide-3-kinase regulatory subunit 2 (Q21496147)

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mammalian protein found in Mus musculus

ptdIns-3-kinase regulatory subunit p85-beta
PI3-kinase subunit p85-beta
phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta
PI3K regulatory subunit beta
phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta)
Pik3r2
phosphatidylinositol 3-kinase regulatory subunit beta
PI3-kinase regulatory subunit beta

Language	Label	Description	Also known as
English	Phosphoinositide-3-kinase regulatory subunit 2	mammalian protein found in Mus musculus	ptdIns-3-kinase regulatory subunit p85-beta PI3-kinase subunit p85-beta phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta PI3K regulatory subunit beta phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) Pik3r2 phosphatidylinositol 3-kinase regulatory subunit beta PI3-kinase regulatory subunit beta

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

19 January 2017

UniProt protein ID

SH3-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08908

Rho GTPase activation protein

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08908

SH2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08908

PI3K p85 subunit, inter-SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Rho GTPase-activating protein domain family

1 reference

based on heuristic

inferred from protein domain or family

PI3K p85 subunit, C-terminal SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PI3K p85 subunit, N-terminal SH2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

SH3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

phosphatidylinositol 3-kinase regulatory subunit binding

determination method or standard

1 reference

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

receptor tyrosine kinase binding

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

transcription factor binding

determination method or standard

1 reference

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

1-phosphatidylinositol-3-kinase regulator activity

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

protein binding

determination method or standard

5 references

14 February 2019

NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

14 February 2019

Enkurin is a novel calmodulin and TRPC channel binding protein in sperm

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

14 February 2019

SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

14 February 2019

Phosphoinositide 3-kinase p85beta regulates invadopodium formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

14 February 2019

Bioinformatics and cellular signaling

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

protein heterodimerization activity

determination method or standard

1 reference

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

protein phosphatase binding

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

phosphotyrosine residue binding

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

phosphatidylinositol 3-kinase regulator activity

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

determination method or standard

1 reference

14 February 2019

Phosphoinositide 3-kinase p85beta regulates invadopodium formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

biological process

cellular glucose homeostasis

determination method or standard

1 reference

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

response to endoplasmic reticulum stress

determination method or standard

1 reference

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

regulation of stress fiber assembly

determination method or standard

1 reference

14 February 2019

Phosphoinositide 3-kinase p85beta regulates invadopodium formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

regulation of actin filament polymerization

determination method or standard

1 reference

14 February 2019

Phosphoinositide 3-kinase p85beta regulates invadopodium formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

regulation of phosphatidylinositol 3-kinase activity

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

cellular response to insulin stimulus

determination method or standard

1 reference

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

protein transport

determination method or standard

1 reference

14 February 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

signal transduction

determination method or standard

1 reference

14 February 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

positive regulation of cell adhesion

determination method or standard

1 reference

14 February 2019

Phosphoinositide 3-kinase p85beta regulates invadopodium formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

positive regulation of transcription by RNA polymerase II

determination method or standard

1 reference

14 February 2019

The regulatory subunits of PI3K, p85alpha and p85beta, interact with XBP-1 and increase its nuclear translocation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

regulation of protein localization to plasma membrane

determination method or standard

1 reference

14 February 2019

Phosphoinositide 3-kinase p85beta regulates invadopodium formation

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

negative regulation of MAPK cascade

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

insulin receptor signaling pathway

determination method or standard

positive regulation of protein import into nucleus

determination method or standard

negative regulation of cell migration involved in sprouting angiogenesis

determination method or standard

1 reference

14 February 2019

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

phosphatidylinositol phosphate biosynthetic process

determination method or standard

1 reference

14 February 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O08908

determination method or standard

Rho GTPase-activating protein domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08908

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08908

PI3K p85 subunit, inter-SH2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08908

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08908

PI3K p85 subunit, C-terminal SH2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08908

PI3K p85 subunit, N-terminal SH2 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08908

Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O08908

Identifiers

RefSeq protein ID

1 reference

20 March 2022

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

ENSMUSP00000034296

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000034296

ENSMUSP00000122065

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000122065

ENSMUSP00000121463

1 reference

ensembl Release 106

Ensembl protein ID

ENSMUSP00000121463

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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