The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells (Q21195261)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21752263

7 December 2024

Min Mei Huang

2

Min Mei

Huang

1 reference

18 August 2022

Michelle Francesco

3

Michelle

Francesco

1 reference

18 August 2022

Jun Chen

4

Jun

Chen

1 reference

18 August 2022

Jeremy Sokolove

5

Jeremy

Sokolove

1 reference

18 August 2022

Padmaja Magadala

6

Padmaja

Magadala

1 reference

18 August 2022

Betty Y. Chang

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21752263

7 December 2024

Joseph J. Buggy

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21752263

7 December 2024

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English

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publication date

2011

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13 July 2011

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21752263

full work available at URL

7 December 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239353

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https://arthritis-research.biomedcentral.com/track/pdf/10.1186/ar3400

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21752263

https://europepmc.org/articles/PMC3239353

7 December 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21752263

https://europepmc.org/articles/PMC3239353?pdf=render

7 December 2024

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC:MED AND EXT_ID:21752263

https://link.springer.com/content/pdf/10.1186/ar3400.pdf

7 December 2024

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https://link.springer.com/article/10.1186/ar3400/fulltext.html

7 December 2024

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Arthritis Research and Therapy

7 December 2024

published in

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volume

13

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issue

4

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page(s)

R115

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cites work

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

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Fcgamma receptors as regulators of immune responses

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Evolving concepts of rheumatoid arthritis

7 April 2017

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Novel therapeutic agents for B-cell lymphoma: developing rational combinations

7 April 2017

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Tyrosine kinases as targets for the treatment of rheumatoid arthritis

12 September 2017

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Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis

12 September 2017

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R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation

12 September 2017

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12 September 2017

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Common mechanisms in immune-mediated inflammatory disease

12 September 2017

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Targeting Syk as a treatment for allergic and autoimmune disorders

12 September 2017

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Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production

12 September 2017

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Roles of Fc receptors in autoimmunity

12 September 2017

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Regulation of B lymphocyte development and activation by Bruton's tyrosine kinase

12 September 2017

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A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase

12 September 2017

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The Arthus reaction in rodents: species-specific requirement of complement

12 September 2017

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Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production

12 September 2017

1 reference

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Btk/Tec kinases regulate sustained increases in intracellular Ca2 following B-cell receptor activation

12 September 2017

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Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

12 September 2017

1 reference

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Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data

12 September 2017

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Antibody-dependent antitumor cytotoxicity by human monocytes cultured with recombinant macrophage colony-stimulating factor. Induction of efficient antibody-mediated antitumor cytotoxicity not detected by isotope release assays

12 September 2017

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CBA/N X-linked B-cell defect prevents NZB B-cell hyperactivity in F1 mice

12 September 2017

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A multitude of kinases--which are the best targets in treating rheumatoid arthritis?

12 September 2017

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Dual functions of Bruton's tyrosine kinase and Tec kinase during Fcgamma receptor-induced signaling and phagocytosis.

27 September 2017

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Defective B cell development and function in Btk-deficient mice

27 September 2017

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Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll‐like receptor 4 and Fcγ receptor

27 September 2017

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Altered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells

30 May 2018

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Mutation of unique region of Bruton's tyrosine kinase in immunodeficient XID mice

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Pleiotropic consequences of Bruton tyrosine kinase deficiency in myeloid lineages lead to poor inflammatory responses

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21 January 2018

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Activation of human mast cells by aggregated IgG through FcgammaRI: additive effects of C3a.

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Arthritis critically dependent on innate immune system players

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Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals.

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Quantitative analysis of micro-CT imaging and histopathological signatures of experimental arthritis in rats

21 January 2018

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12 December 2020

Bruton's tyrosine kinase is not essential for LPS-induced activation of human monocytes

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12 December 2020

Histamine release from human buffy coat-derived mast cells

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12 December 2020

Inflammation and bone erosion are suppressed in models of rheumatoid arthritis following treatment with a novel Syk inhibitor

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12 December 2020

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12 December 2020

Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors

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12 December 2020

Macrophage effector functions controlled by Bruton's tyrosine kinase are more crucial than the cytokine balance of T cell responses for microfilarial clearance

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12 December 2020

Essential role of Fc gamma receptors in anti-type II collagen antibody-induced arthritis

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12 December 2020

Defective Fc-, CR1- and CR3-mediated monocyte phagocytosis and chemotaxis in common variable immunodeficiency and X-linked agammaglobulinemia patients

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12 December 2020

The interaction of the xid and me genes

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12 December 2020

Genes on the X chromosome affect development of collagen-induced arthritis in mice

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12 December 2020

Transphosphorylation of Bruton's tyrosine kinase on tyrosine 551 is critical for B cell antigen receptor function

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12 December 2020

The Journal of rheumatology. Supplement

44

73

8

GS Firestein

2005

1 reference

7 December 2024

Identifiers

DOI

10.1186/AR3400

0 references

0 references

PMC publication ID

3239353

0 references