Small nuclear ribonucleoprotein U5 subunit 200 (Q21173803)

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mammalian protein found in Homo sapiens

U5 snRNP-specific 200 kDa protein
U5 small nuclear ribonucleoprotein 200 kDa helicase
bad response to refrigeration 2 homolog
activating signal cointegrator 1 complex subunit 3-like 1
U5-200KD
SNRNP200
small nuclear ribonucleoprotein, U5 200kDa subunit
BRR2 homolog
small nuclear ribonucleoprotein 200kDa (U5)

Language	Label	Description	Also known as
English	Small nuclear ribonucleoprotein U5 subunit 200	mammalian protein found in Homo sapiens	U5 snRNP-specific 200 kDa protein U5 small nuclear ribonucleoprotein 200 kDa helicase bad response to refrigeration 2 homolog activating signal cointegrator 1 complex subunit 3-like 1 U5-200KD SNRNP200 small nuclear ribonucleoprotein, U5 200kDa subunit BRR2 homolog small nuclear ribonucleoprotein 200kDa (U5)

Statements

1 reference

13 November 2019

UniProt protein ID

winged helix DNA-binding domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75643

C2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75643

Immunoglobulin E-set

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75643

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/O75643

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Helicase superfamily 1/2, ATP-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Helicase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DEAD/DEAH box helicase

1 reference

based on heuristic

inferred from protein domain or family

Sec63 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

helicase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

helicase activity

determination method or standard

1 reference

17 October 2017

The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplicesin vitro

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75643&geneProductId=UniProtKB:O75643

determination method or standard

protein binding

determination method or standard

6 references

8 April 2019

PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

8 April 2019

Death by splicing: tumor suppressor RBM5 freezes splice-site pairing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

8 April 2019

A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

8 April 2019

A new role for FBP21 as regulator of Brr2 helicase activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

8 April 2019

Dynamic protein-protein interaction wiring of the human spliceosome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

8 April 2019

The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

identical protein binding

determination method or standard

1 reference

8 April 2019

Dynamic protein-protein interaction wiring of the human spliceosome

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

nucleic acid binding

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

hydrolase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

determination method or standard

catalytic step 2 spliceosome

determination method or standard

1 reference

17 October 2017

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75643&geneProductId=UniProtKB:O75643

determination method or standard

determination method or standard

1 reference

17 October 2017

Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75643&geneProductId=UniProtKB:O75643

determination method or standard

determination method or standard

1 reference

17 October 2017

The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplicesin vitro

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75643&geneProductId=UniProtKB:O75643

determination method or standard

spliceosomal complex

determination method or standard

U4/U6 x U5 tri-snRNP complex

determination method or standard

1 reference

17 October 2017

The nuclear cap-binding complex interacts with the U4/U6·U5 tri-snRNP and promotes spliceosome assembly in mammalian cells

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75643&geneProductId=UniProtKB:O75643

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

8 April 2019

PHF6 interacts with the nucleosome remodeling and deacetylation (NuRD) complex

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

spliceosomal complex

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

8 April 2019

The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

determination method or standard

1 reference

8 April 2019

Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

U4/U6 x U5 tri-snRNP complex

determination method or standard

catalytic step 2 spliceosome

determination method or standard

post-mRNA release spliceosomal complex

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

biological process

mRNA splicing, via spliceosome

determination method or standard

3 references

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75643&geneProductId=UniProtKB:O75643

determination method or standard

17 October 2017

The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75643&geneProductId=UniProtKB:O75643

determination method or standard

17 October 2017

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75643&geneProductId=UniProtKB:O75643

determination method or standard

mRNA processing

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

osteoblast differentiation

determination method or standard

1 reference

17 October 2017

Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=O75643&geneProductId=UniProtKB:O75643

determination method or standard

cis assembly of pre-catalytic spliceosome

determination method or standard

1 reference

8 April 2019

The human U5-200kD DEXH-box protein unwinds U4/U6 RNA duplicesin vitro

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

mRNA splicing, via spliceosome

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

8 April 2019

The HeLa 200 kDa U5 snRNP-specific protein and its homologue in Saccharomyces cerevisiae are members of the DEXH-box protein family of putative RNA helicases

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

8 April 2019

Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

osteoblast differentiation

determination method or standard

1 reference

8 April 2019

Differential expression profiling of membrane proteins by quantitative proteomics in a human mesenchymal stem cell line undergoing osteoblast differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O75643

determination method or standard

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000317123

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000317123

ENSP00000498933

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000498933

PDB structure ID

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

1 reference

UniProt protein ID

4 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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