Eukaryotic translation initiation factor 2 alpha kinase 3 (Q21172758)

Protein kinase-like domain superfamily

1 reference

WD40/YVTN repeat-like-containing domain superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Protein kinase domain, protein family

1 reference

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

inferred from protein domain or family

1 reference

16 January 2019

1 reference

16 January 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

Hsp90 protein binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

protein homodimerization activity

1 reference

8 April 2019

The endoplasmic reticulum stress response in aging and age-related diseases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

protein serine/threonine kinase activity

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5

5 references

8 April 2019

TMEM33: a new stress-inducible endoplasmic reticulum transmembrane protein and modulator of the unfolded protein response signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

TBL2 is a novel PERK-binding protein that modulates stress-signaling and cell survival during endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Compounds Triggering ER Stress Exert Anti-Melanoma Effects and Overcome BRAF Inhibitor Resistance

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

identical protein binding

IPI

1 reference

8 April 2019

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

1 reference

8 April 2019

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

protein phosphatase binding

IPI

1 reference

8 April 2019

H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

2 references

eukaryotic translation initiation factor 2alpha kinase activity

6 references

26 September 2017

p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5

26 September 2017

Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5

26 September 2017

Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5

26 September 2017

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5

26 September 2017

Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5

Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells

protein kinase activity

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

eukaryotic translation initiation factor 2alpha kinase activity

IBA

7 references

8 April 2019

Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

protein serine/threonine kinase activity

IBA

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

integral component of membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

endoplasmic reticulum membrane

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene

endoplasmic reticulum

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

perinuclear region of cytoplasm

IC

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

skeletal system development

IBA

biological process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

insulin-like growth factor receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

negative regulation of translation

1 reference

8 April 2019

Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation

TAS

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

cellular response to glucose starvation

1 reference

8 April 2019

The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

negative regulation of translation in response to stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

1 reference

8 April 2019

Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

negative regulation of translational initiation in response to stress

3 references

8 April 2019

Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

cellular response to amino acid starvation

1 reference

8 April 2019

p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

chondrocyte development

1 reference

8 April 2019

regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

1 reference

8 April 2019

Ursolic acid induces ER stress response to activate ASK1-JNK signaling and induce apoptosis in human bladder cancer T24 cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

1 reference

26 September 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9NZJ5&geneProductId=UniProtKB:Q9NZJ5

endoplasmic reticulum organization

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

response to endoplasmic reticulum stress

1 reference

8 April 2019

Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

2 references

8 April 2019

Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

response to manganese-induced endoplasmic reticulum stress

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

endoplasmic reticulum unfolded protein response

4 references

8 April 2019

Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Pancreatic eukaryotic initiation factor-2alpha kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

response to unfolded protein

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

positive regulation of gene expression

1 reference

8 April 2019

The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

cellular response to cold

1 reference

8 April 2019

p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

peptidyl-serine phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

1 reference

8 April 2019

The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

eiF2alpha phosphorylation in response to endoplasmic reticulum stress

TAS

protein autophosphorylation

4 references

8 April 2019

Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

8 April 2019

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

positive regulation of vascular endothelial growth factor production

1 reference

8 April 2019

The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

positive regulation of transcription by RNA polymerase I

1 reference

8 April 2019

The unfolded protein response induces the angiogenic switch in human tumor cells through the PERK/ATF4 pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

protein homooligomerization

1 reference

8 April 2019

Dimerization and release of molecular chaperone inhibition facilitate activation of eukaryotic initiation factor-2 kinase in response to endoplasmic reticulum stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

activation of cysteine-type endopeptidase activity involved in apoptotic process

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

negative regulation of myelination

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

regulation of translation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

calcium-mediated signaling

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

endocrine pancreas development

1 reference

8 April 2019

Loss of kinase activity in a patient with Wolcott-Rallison syndrome caused by a novel mutation in the EIF2AK3 gene

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

positive regulation of protein localization to nucleus

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

regulation of translational initiation by eIF2 alpha phosphorylation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9NZJ5

serine/threonine-protein kinase, active site

has part(s)

1 reference

protein kinase domain

1 reference

protein kinase, ATP binding site

1 reference

Identifiers

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

8 February 2019

1 reference

16 January 2019

1 reference

1 reference

1 reference

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016

1 reference

4 August 2016