DEAD-box helicase 6 (Q21172262)

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mammalian protein found in Homo sapiens

ATP-dependent RNA helicase p54
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD)
probable ATP-dependent RNA helicase DDX6
oncogene RCK
DEAD box protein 6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 6
DEAD (Asp-Glu-Ala-Asp) box helicase 6
DEAD box-6
DDX6

Language	Label	Description	Also known as
English	DEAD-box helicase 6	mammalian protein found in Homo sapiens	ATP-dependent RNA helicase p54 DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 6 (RNA helicase, 54kD) probable ATP-dependent RNA helicase DDX6 oncogene RCK DEAD box protein 6 DEAD (Asp-Glu-Ala-Asp) box polypeptide 6 DEAD (Asp-Glu-Ala-Asp) box helicase 6 DEAD box-6 DDX6

Statements

1 reference

13 November 2019

UniProt protein ID

P-loop containing nucleoside triphosphate hydrolase

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26196

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Helicase superfamily 1/2, ATP-binding domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Helicase, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

DEAD/DEAH box helicase

1 reference

based on heuristic

inferred from protein domain or family

RNA helicase, DEAD-box type, Q motif, protein family

1 reference

based on heuristic

inferred from protein domain or family

ATP-dependent RNA helicase DEAD-box, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

RNA helicase activity

determination method or standard

1 reference

8 April 2019

Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

helicase activity

determination method or standard

3 references

8 April 2019

Cloning, expression and localization of an RNA helicase gene from a human lymphoid cell line with chromosomal breakpoint 11q23.3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

The RCK gene associated with t(11;14) translocation is distinct from the MLL/ALL-1 gene with t(4;11) and t(11;19) translocations

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

protein domain specific binding

determination method or standard

1 reference

8 April 2019

A DDX6-CNOT1 complex and W-binding pockets in CNOT9 reveal direct links between miRNA target recognition and silencing

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

protein binding

determination method or standard

15 references

8 April 2019

Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

The C-terminal alpha-alpha superhelix of Pat is required for mRNA decapping in metazoa

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

Human Pat1b connects deadenylation with mRNA decapping and controls the assembly of processing bodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

Ataxin-2 interacts with the DEAD/H-box RNA helicase DDX6 and interferes with P-bodies and stress granules

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

DCP1 forms asymmetric trimers to assemble into active mRNA decapping complexes in metazoa

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

Mammalian microtubule P-body dynamics are mediated by nesprin-1.

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

nucleic acid binding

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

hydrolase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

determination method or standard

3 references

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26196&geneProductId=UniProtKB:P26196

determination method or standard

17 October 2017

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26196&geneProductId=UniProtKB:P26196

determination method or standard

17 October 2017

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26196&geneProductId=UniProtKB:P26196

determination method or standard

cadherin binding

determination method or standard

1 reference

17 October 2017

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26196&geneProductId=UniProtKB:P26196

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

cadherin binding

determination method or standard

1 reference

8 April 2019

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

Comprehensive Protein Interactome Analysis of a Key RNA Helicase: Detection of Novel Stress Granule Proteins

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

determination method or standard

1 reference

8 April 2019

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

determination method or standard

1 reference

17 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26196&geneProductId=UniProtKB:P26196

determination method or standard

determination method or standard

8 references

8 April 2019

The DEAD-box RNA helicase DDX6 is required for efficient encapsidation of a retroviral genome

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

HIV-1 replication and APOBEC3 antiviral activity are not regulated by P bodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

Distinct functions of maternal and somatic Pat1 protein paralogs

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

8 April 2019

LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

cytoplasmic stress granule

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

determination method or standard

1 reference

17 October 2017

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26196&geneProductId=UniProtKB:P26196

determination method or standard

outer dense fiber

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

heterochromatin

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

cytoplasmic ribonucleoprotein granule

determination method or standard

1 reference

8 April 2019

Human Protein Atlas

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

determination method or standard

1 reference

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

chromatoid body

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

perinuclear region of cytoplasm

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

concave side of sperm head

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

biological process

negative regulation of neuron differentiation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

stem cell population maintenance

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

RNA secondary structure unwinding

determination method or standard

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26196&geneProductId=UniProtKB:P26196

determination method or standard

P-body assembly

determination method or standard

1 reference

8 April 2019

Distinct functions of maternal and somatic Pat1 protein paralogs

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

exonucleolytic catabolism of deadenylated mRNA

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

viral RNA genome packaging

determination method or standard

1 reference

8 April 2019

The DEAD-box RNA helicase DDX6 is required for efficient encapsidation of a retroviral genome

Community Assessment of Community Annotation with Ontologies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

regulation of translation

determination method or standard

1 reference

17 October 2017

http://www.ebi.ac.uk/QuickGO/annotations?protein=P26196&geneProductId=UniProtKB:P26196

determination method or standard

spermatogenesis

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

spermatid differentiation

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P26196

determination method or standard

DEAD/DEAH box helicase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26196

ATP-dependent RNA helicase DEAD-box, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26196

RNA helicase, DEAD-box type, Q motif

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26196

Helicase, C-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26196

Helicase superfamily 1/2, ATP-binding domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P26196

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000433704

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000433704

ENSP00000442266

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000442266

ENSP00000478754

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000478754

ENSP00000483902

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000483902

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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