Protein tyrosine phosphatase non-receptor type 2 (Q21171735)

From Wikidata

Jump to navigation Jump to search

mammalian protein found in Homo sapiens

T-cell protein tyrosine phosphatase
tyrosine-protein phosphatase non-receptor type 2
TCPTP
PTPN2
T-cell protein-tyrosine phosphatase
Protein Tyrosine Phosphatase, Non-Receptor Type 2

Language	Label	Description	Also known as
English	Protein tyrosine phosphatase non-receptor type 2	mammalian protein found in Homo sapiens	T-cell protein tyrosine phosphatase tyrosine-protein phosphatase non-receptor type 2 TCPTP PTPN2 T-cell protein-tyrosine phosphatase Protein Tyrosine Phosphatase, Non-Receptor Type 2

Statements

1 reference

13 November 2019

UniProt protein ID

Protein-tyrosine phosphatase, non-receptor type-1/2

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17706

Protein-tyrosine phosphatase-like

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P17706

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Tyrosine specific protein phosphatases domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

PTP type protein phosphatase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein-tyrosine phosphatase, catalytic domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein-tyrosine phosphatase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method or standard

4 references

8 April 2019

T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

8 April 2019

Selective regulation of tumor necrosis factor-induced Erk signaling by Src family kinases and the T cell protein tyrosine phosphatase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

8 April 2019

Evidence for a role of transmembrane protein p25 in localization of protein tyrosine phosphatase TC48 to the ER

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

8 April 2019

Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

protein kinase binding

determination method or standard

1 reference

8 April 2019

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

phosphatase activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

integrin binding

determination method or standard

1 reference

8 April 2019

Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

phosphoprotein phosphatase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

syntaxin binding

determination method or standard

1 reference

8 April 2019

Tyrosine phosphorylation of a SNARE protein, syntaxin 17: implications for membrane trafficking in the early secretory pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

non-membrane spanning protein tyrosine phosphatase activity

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

receptor tyrosine kinase binding

determination method or standard

1 reference

8 April 2019

Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

hydrolase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

protein tyrosine phosphatase activity

determination method or standard

8 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

1 January 2018

Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

1 January 2018

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

1 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

1 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

1 January 2018

Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

1 January 2018

Identification of a nuclear Stat1 protein tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

STAT family protein binding

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

protein tyrosine phosphatase activity

determination method or standard

7 references

8 April 2019

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

8 April 2019

Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

8 April 2019

Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

8 April 2019

Identification of a nuclear Stat1 protein tyrosine phosphatase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

determination method or standard

4 references

31 January 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

31 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

31 January 2018

COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

31 January 2018

Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

biological process

negative regulation of epidermal growth factor receptor signaling pathway

determination method or standard

1 reference

8 April 2019

Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

positive regulation of PERK-mediated unfolded protein response

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

dephosphorylation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

negative regulation of interleukin-4-mediated signaling pathway

determination method or standard

positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

negative regulation of interleukin-6-mediated signaling pathway

determination method or standard

negative regulation of cell population proliferation

determination method or standard

1 reference

8 April 2019

Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

regulation of interferon-gamma-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

negative regulation of protein tyrosine kinase activity

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

regulation of hepatocyte growth factor receptor signaling pathway

determination method or standard

1 reference

8 April 2019

Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

peptidyl-tyrosine dephosphorylation

determination method or standard

5 references

31 January 2018

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

31 January 2018

Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

31 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

31 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

31 January 2018

Identification of a nuclear Stat1 protein tyrosine phosphatase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

negative regulation of transcription by RNA polymerase II

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

negative regulation of tyrosine phosphorylation of STAT protein

determination method or standard

5 references

31 January 2018

T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

31 January 2018

Identification of a nuclear Stat1 protein tyrosine phosphatase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

31 January 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

31 January 2018

Identification of a nuclear Stat1 protein tyrosine phosphatase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

31 January 2018

The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17706&geneProductId=UniProtKB:P17706

determination method or standard

cellular response to cytokine stimulus

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

peptidyl-tyrosine dephosphorylation

determination method or standard

3 references

8 April 2019

The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

8 April 2019

Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

negative regulation of interleukin-6-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

negative regulation of interleukin-4-mediated signaling pathway

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17706

determination method or standard

Identifiers

MeSH descriptor ID

subject named as

Protein Tyrosine Phosphatase, Non-Receptor Type 2

0 references

D08.811.277.352.650.775.300.200

0 references

D12.776.476.564.300.200

0 references

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000311857

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000311857

ENSP00000320298

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000320298

ENSP00000320546

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000320546

ENSP00000466936

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466936

ENSP00000464719

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464719

ENSP00000464937

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464937

ENSP00000466206

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000466206

ENSP00000467043

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000467043

ENSP00000467823

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000467823

ENSP00000468012

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468012

ENSP00000468155

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468155

ENSP00000468408

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000468408

ENSP00000496181

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000496181

ENSP00000494336

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000494336

ENSP00000493693

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000493693

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q21171735&oldid=2245776290"