Mitogen-activated protein kinase 12 (Q21156651)

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mammalian protein found in Homo sapiens

mitogen-activated protein kinase 3
MAP kinase 12
extracellular signal-regulated kinase 6
MAP kinase p38 gamma
mitogen-activated protein kinase p38 gamma
ERK-6
mitogen-activated protein kinase 12
stress-activated protein kinase 3
MAPK12

Language	Label	Description	Also known as
English	Mitogen-activated protein kinase 12	mammalian protein found in Homo sapiens	mitogen-activated protein kinase 3 MAP kinase 12 extracellular signal-regulated kinase 6 MAP kinase p38 gamma mitogen-activated protein kinase p38 gamma ERK-6 mitogen-activated protein kinase 12 stress-activated protein kinase 3 MAPK12

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53778

mitogen-activated protein kinase 12

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53778

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Mitogen-activated protein (MAP) kinase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

protein kinase activity

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

nucleotide binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

metal ion binding

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

kinase activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

protein binding

determination method or standard

8 references

8 April 2019

Phosphorylation of the mitochondrial protein Sab by stress-activated protein kinase 3

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

Proteomic analysis of GTP cyclohydrolase 1 multiprotein complexes in cultured normal adult human astrocytes under both basal and cytokine-activated conditions

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

Regulation of the catalytic activity of the human phosphatase PTPN4 by its PDZ domain

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

Proteome-wide analysis of phospho-regulated PDZ domain interactions

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

determination method or standard

magnesium ion binding

determination method or standard

1 reference

8 April 2019

The structure of phosphorylated p38gamma is monomeric and reveals a conserved activation-loop conformation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

protein serine/threonine kinase activity

determination method or standard

5 references

8 April 2019

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

The phosphorylation of CapZ-interacting protein (CapZIP) by stress-activated protein kinases triggers its dissociation from CapZ

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

MAP kinase activity

determination method or standard

5 references

8 April 2019

Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

determination method or standard

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

biological process

regulation of transcription, DNA-templated

determination method or standard

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53778&geneProductId=UniProtKB:P53778

determination method or standard

phosphorylation

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

positive regulation of muscle cell differentiation

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

muscle organ development

determination method or standard

1 reference

8 April 2019

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

negative regulation of cell cycle

determination method or standard

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53778&geneProductId=UniProtKB:P53778

determination method or standard

positive regulation of peptidase activity

determination method or standard

1 reference

8 April 2019

Biochemical aspects of the neuroprotective mechanism of PTEN-induced kinase-1 (PINK1)

Parkinsons Disease Gene Ontology Initiative

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

peptidyl-serine phosphorylation

determination method or standard

DNA damage induced protein phosphorylation

determination method or standard

1 reference

8 April 2019

Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

myoblast differentiation

determination method or standard

1 reference

8 April 2019

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

signal transduction

determination method or standard

1 reference

8 April 2019

ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

determination method or standard

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

regulation of gene expression

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

intracellular signal transduction

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

cellular response to organic substance

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53778

determination method or standard

protein kinase, ATP binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53778

protein kinase domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53778

mitogen-activated protein (MAP) kinase, conserved site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53778

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000215659

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000215659

ENSP00000479972

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000479972

ENSP00000379124

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000379124

ENSP00000379126

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000379126

PDB structure ID

1 reference

UniProt protein ID

30 June 2016

language of work or name

1 reference

UniProt protein ID

30 June 2016

language of work or name

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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