Flap structure-specific endonuclease 1 (Q21154944)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P39748

5'-3' exonuclease, C-terminal domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P39748

Flap endonuclease 1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P39748

membrane protein

1 reference

inferred from GOA cell component → membrane

XPG N-terminal domain, protein family

1 reference

XPG-I domain, protein family

1 reference

XPG conserved site, protein family

1 reference

Helix-hairpin-helix motif, class 2, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

1 reference

8 April 2019

RNA-DNA hybrid ribonuclease activity

1 reference

17 October 2017

Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

hydrolase activity, acting on ester bonds

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

1 reference

8 April 2019

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

1 reference

8 April 2019

double-stranded DNA binding

1 reference

8 April 2019

The characterization of a mammalian DNA structure-specific endonuclease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

catalytic activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

1 reference

8 April 2019

damaged DNA binding

1 reference

8 April 2019

Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

double-stranded DNA exodeoxyribonuclease activity

1 reference

8 April 2019

The characterization of a mammalian DNA structure-specific endonuclease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

protein binding

12 references

8 April 2019

Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

Human MUS81 complexes stimulate flap endonuclease 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

Structural and thermodynamic analysis of human PCNA with peptides derived from DNA polymerase-delta p66 subunit and flap endonuclease-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

A human interactome in three quantitative dimensions organized by stoichiometries and abundances

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

A protein domain-based interactome network for C. elegans early embryogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

Stimulation of flap endonuclease-1 by the Bloom's syndrome protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

DNA binding

Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

5'-3' exonuclease activity

1 reference

17 October 2017

Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

5'-flap endonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

4 references

17 October 2017

17 October 2017

Essential amino acids for substrate binding and catalysis of human flap endonuclease 1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

17 October 2017

Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

17 October 2017

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

flap endonuclease activity

1 reference

17 October 2017

Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

RNA-DNA hybrid ribonuclease activity

5'-3' exonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

3 references

8 April 2019

8 April 2019

Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

5'-flap endonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

6 references

8 April 2019

8 April 2019

Arginine residues 47 and 70 of human flap endonuclease-1 are involved in DNA substrate interactions and cleavage site determination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

Essential amino acids for substrate binding and catalysis of human flap endonuclease 1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

8 April 2019

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

manganese ion binding

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

flap endonuclease activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

5 references

1 January 2018

Ensembl genome database project

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

1 January 2018

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

1 January 2018

Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

1 January 2018

membrane

1 reference

17 October 2017

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

nucleolus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

1 reference

17 October 2017

membrane

HDA

1 reference

8 April 2019

Defining the membrane proteome of NK cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

protein-containing complex

HDA

1 reference

8 April 2019

Opposing roles of mitochondrial and nuclear PARP1 in the regulation of mitochondrial and nuclear DNA integrity: implications for the regulation of mitochondrial function

Mouse Genome Informatics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

6 references

8 April 2019

Ensembl genome database project

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

Structural and functional homology between mammalian DNase IV and the 5'-nuclease domain of Escherichia coli DNA polymerase I

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

double-strand break repair via homologous recombination

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

1 reference

8 April 2019

double-strand break repair

1 reference

8 April 2019

The characterization of a mammalian DNA structure-specific endonuclease

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

memory

Ensembl genome database project

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

cellular response to DNA damage stimulus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

1 reference

8 April 2019

UV protection

1 reference

8 April 2019

Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

DNA repair

Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

8 April 2019

RNA phosphodiester bond hydrolysis, endonucleolytic

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

DNA replication, removal of RNA primer

1 reference

17 October 2017

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

positive regulation of sister chromatid cohesion

1 reference

8 April 2019

Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

nucleic acid phosphodiester bond hydrolysis

1 reference

8 April 2019

Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

telomere maintenance via semi-conservative replication

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

1 reference

8 April 2019

DNA repair

Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

1 January 2018

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

base-excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39748

1 reference

8 April 2019

apoptotic DNA fragmentation

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

DNA replication, removal of RNA primer

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

3 references

1 January 2018

1 January 2018

Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

positive regulation of sister chromatid cohesion

retina development in camera-type eye

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P39748&geneProductId=UniProtKB:P39748

Identifiers

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016