LIM domain kinase 1 (Q21154133)

PDZ superfamily

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Zinc finger, LIM-type, protein family

1 reference

PDZ domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

1 reference

8 April 2019

heat shock protein binding

1 reference

8 April 2019

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

metal ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

1 reference

8 April 2019

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

1 reference

8 April 2019

protein binding

13 references

8 April 2019

Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

The phosphorylation of p25/TPPP by LIM kinase 1 inhibits its ability to assemble microtubules

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

A dimeric kinase assembly underlying autophosphorylation in the p21 activated kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

Regulation of actin function by protein kinase A-mediated phosphorylation of Limk1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

LIM kinase1 modulates function of membrane type matrix metalloproteinase 1: implication in invasion of prostate cancer cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

Protein-protein interaction of zinc finger LIM domains with protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

protein heterodimerization activity

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

protein serine/threonine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

4 references

8 April 2019

8 April 2019

Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

signal transducer activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53667&geneProductId=UniProtKB:P53667

1 reference

31 October 2017

cell component

membrane

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

focal adhesion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53667&geneProductId=UniProtKB:P53667

3 references

5 June 2018

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53667&geneProductId=UniProtKB:P53667

5 June 2018

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53667&geneProductId=UniProtKB:P53667

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

Golgi apparatus

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53667&geneProductId=UniProtKB:P53667

1 reference

5 June 2018

nuclear speck

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

1 reference

8 April 2019

neuron projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

3 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

lamellipodium

ISS

cell projection

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

1 reference

8 April 2019

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

4 references

8 April 2019

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

Fc-gamma receptor signaling pathway involved in phagocytosis

biological process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

1 reference

8 April 2019

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

1 reference

8 April 2019

nervous system development

1 reference

8 April 2019

LIM-kinase1 hemizygosity implicated in impaired visuospatial constructive cognition

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

negative regulation of ubiquitin-protein transferase activity

1 reference

8 April 2019

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

Rho protein signal transduction

1 reference

8 April 2019

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

positive regulation of actin filament bundle assembly

1 reference

8 April 2019

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

actin cytoskeleton organization

1 reference

5 June 2018

Signal-regulated activation of serum response factor is mediated by changes in actin dynamics

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53667&geneProductId=UniProtKB:P53667

protein phosphorylation

Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

β-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

8 April 2019

8 April 2019

Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53667

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

Zinc finger, LIM-type

1 reference

Identifiers

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016