Adrenoceptor alpha 2B (Q21141045)

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mammalian protein found in Homo sapiens

Alpha-2B adrenoceptor
alpha-2B adrenoreceptor
ADRA2B
G-protein coupled receptor
Alpha-2BAR
ADRA2B adrenergic, alpha-2B-, receptor
alpha-2 adrenergic receptor subtype C2
alpha-2B adrenergic receptor
alpha-2-adrenergic receptor-like 1

Language	Label	Description	Also known as
English	Adrenoceptor alpha 2B	mammalian protein found in Homo sapiens	Alpha-2B adrenoceptor alpha-2B adrenoreceptor ADRA2B G-protein coupled receptor Alpha-2BAR ADRA2B adrenergic, alpha-2B-, receptor alpha-2 adrenergic receptor subtype C2 alpha-2B adrenergic receptor alpha-2-adrenergic receptor-like 1

Statements

1 reference

13 November 2019

UniProt protein ID

Alpha 2B adrenoceptor

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18089

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

22 April 2020

UniProt protein ID

1 reference

22 April 2020

UniProt protein ID

molecular function

G protein-coupled receptor activity

determination method or standard

4 references

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

determination method or standard

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

epinephrine binding

determination method or standard

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

protein binding

determination method or standard

5 references

8 April 2019

GGA3 Interacts with a G Protein-Coupled Receptor and Modulates Its Cell Surface Export.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

The α2B-adrenergic receptor is mutant in cortical myoclonus and epilepsy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

Rab26 modulates the cell surface transport of α2-adrenergic receptors from the Golgi

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

alpha2-adrenergic receptor activity

determination method or standard

4 references

8 April 2019

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

integral component of membrane

determination method or standard

4 references

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

determination method or standard

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

plasma membrane

determination method or standard

1 reference

3 January 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

determination method or standard

plasma membrane

determination method or standard

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

integral component of plasma membrane

determination method or standard

1 reference

21 June 2018

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18089&geneProductId=UniProtKB:P18089

determination method or standard

intracellular anatomical structure

determination method or standard

1 reference

10 September 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18089&geneProductId=UniProtKB:P18089

determination method or standard

integral component of plasma membrane

determination method or standard

determination method or standard

1 reference

8 April 2019

Regulation of α2B-Adrenergic Receptor Cell Surface Transport by GGA1 and GGA2

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

biological process

adrenergic receptor signaling pathway

determination method or standard

1 reference

3 January 2017

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=A2RUS0

determination method or standard

G protein-coupled receptor signaling pathway

determination method or standard

4 references

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18089&geneProductId=UniProtKB:P18089

determination method or standard

5 June 2018

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18089&geneProductId=UniProtKB:P18089

determination method or standard

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18089&geneProductId=UniProtKB:P18089

determination method or standard

5 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P18089&geneProductId=UniProtKB:P18089

determination method or standard

activation of protein kinase B activity

determination method or standard

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

negative regulation of epinephrine secretion

determination method or standard

1 reference

8 April 2019

Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

cell-cell signaling

determination method or standard

1 reference

8 April 2019

Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

adenylate cyclase-activating adrenergic receptor signaling pathway

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

positive regulation of neuron differentiation

determination method or standard

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

negative regulation of norepinephrine secretion

determination method or standard

2 references

8 April 2019

Interaction of the ubiquitin carboxyl terminal esterase L1 with alpha(2)-adrenergic receptors inhibits agonist-mediated p44/42 MAP kinase activation

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

Interaction of the amyloid precursor like protein 1 with the alpha2A-adrenergic receptor increases agonist-mediated inhibition of adenylate cyclase

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

positive regulation of MAPK cascade

determination method or standard

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

adrenergic receptor signaling pathway

determination method or standard

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

G protein-coupled receptor signaling pathway

determination method or standard

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

receptor transactivation

determination method or standard

1 reference

8 April 2019

Delayed transactivation of the receptor for nerve growth factor is required for sustained signaling and differentiation by alpha2-adrenergic receptors in transfected PC12 cells

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

adenylate cyclase-modulating G protein-coupled receptor signaling pathway

determination method or standard

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P18089

determination method or standard

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

dexmedetomidine

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

phenoxybenzamine

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL677

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL679

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1437

(−)-ephedrine

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL211456

apraclonidine hydrochloride

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200379

dipivefrin hydrochloride

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200833

oxymetazoline hydrochloride

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200791

phenoxybenzamine hydrochloride

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200787

dexmedetomidine hydrochloride

object of statement has role

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2106195

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P18089

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

22 April 2020

UniProt protein ID

Ensembl protein ID

ENSP00000480573

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000480573

PDB structure ID

1 reference

14 November 2015

http://www.uniprot.org/uniprot/P18089.txt?version=162

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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