fibroblast growth factor receptor 4 (Q21137668)

Protein kinase-like domain superfamily

1 reference

Immunoglobulin-like domain superfamily

1 reference

fibroblast growth factor receptor family

1 reference

membrane protein

1 reference

inferred from GOA cell component → membrane

Immunoglobulin I-set, protein family

1 reference

Serine-threonine/tyrosine-protein kinase, catalytic domain, protein family

1 reference

Immunoglobulin subtype, protein family

1 reference

Immunoglobulin subtype 2, protein family

1 reference

Protein kinase domain, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Tyrosine-protein kinase, catalytic domain, protein family

1 reference

Tyrosine-protein kinase, active site, protein family

1 reference

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

nucleotide binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

protein kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

heparin binding

1 reference

8 April 2019

Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

transmembrane receptor protein tyrosine kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

1 reference

27 March 2018

protein tyrosine kinase activity

fibroblast growth factor binding

Liver-specific activities of FGF19 require Klotho beta

4 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

27 March 2018

FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

27 March 2018

Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

27 March 2018

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

fibroblast growth factor-activated receptor activity

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

7 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

27 March 2018

FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

27 March 2018

Ensembl genome database project

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

27 March 2018

Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

27 March 2018

Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

27 March 2018

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

phosphatidylinositol-4,5-bisphosphate 3-kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

1 reference

1 January 2018

1-phosphatidylinositol-3-kinase activity

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

1 reference

1 January 2018

transmembrane signaling receptor activity

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

fibroblast growth factor-activated receptor activity

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Ensembl genome database project

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

fibroblast growth factor binding

Liver-specific activities of FGF19 require Klotho beta

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Ubiquitination of fibroblast growth factor receptor 1 is required for its intracellular sorting but not for its endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

cell component

endosome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

Golgi apparatus

1 reference

8 April 2019

The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

cell-cell junction

1 reference

8 April 2019

FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

8 April 2019

The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

integral component of plasma membrane

transport vesicle

1 reference

8 April 2019

The cell surface receptor FGFRL1 forms constitutive dimers that promote cell adhesion

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

integral component of plasma membrane

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

receptor complex

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

biological process

glucose homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

phosphate ion homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

response to bile acid

1 reference

8 April 2019

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

regulation of extracellular matrix disassembly

1 reference

8 April 2019

Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

MAPK cascade

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

regulation of bile acid biosynthetic process

2 references

10 September 2018

Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

10 September 2018

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

fibroblast growth factor receptor signaling pathway

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

7 references

8 April 2019

8 April 2019

Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

FGF-19, a novel fibroblast growth factor with unique specificity for FGFR4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Ensembl genome database project

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

regulation of lipid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

protein phosphorylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

positive regulation of gene expression

1 reference

8 April 2019

Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

positive regulation of cell population proliferation

Receptor specificity of the fibroblast growth factor family

3 references

27 March 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

27 March 2018

27 March 2018

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

positive regulation of DNA biosynthetic process

1 reference

8 April 2019

Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

positive regulation of ERK1 and ERK2 cascade

1 reference

27 March 2018

Sulfated glycosaminoglycans are required for specific and sensitive fibroblast growth factor (FGF) 19 signaling via FGF receptor 4 and betaKlotho

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

positive regulation of proteolysis

1 reference

8 April 2019

FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

protein autophosphorylation

1 reference

8 April 2019

FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

peptidyl-tyrosine phosphorylation

2 references

cell migration

1 reference

8 April 2019

Fibroblast growth factor receptor 4 regulates tumor invasion by coupling fibroblast growth factor signaling to extracellular matrix degradation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

phosphatidylinositol phosphate biosynthetic process

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

positive regulation of catalytic activity

1 reference

8 April 2019

FGF receptor-4 (FGFR4) polymorphism acts as an activity switch of a membrane type 1 matrix metalloproteinase-FGFR4 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

phosphatidylinositol-3-phosphate biosynthetic process

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

positive regulation of protein kinase B signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

cholesterol homeostasis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

1 reference

8 April 2019

angiogenesis

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

positive regulation of cell population proliferation

Receptor specificity of the fibroblast growth factor family

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

8 April 2019

Receptor specificity of the fibroblast growth factor family

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

negative regulation of signal transduction

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

cell differentiation

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

negative regulation of apoptotic process

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P22455&geneProductId=UniProtKB:P22455

positive regulation of ERK1 and ERK2 cascade

transmembrane receptor protein tyrosine kinase signaling pathway

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

nervous system development

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

regulation of bile acid biosynthetic process

Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19-mediated down-regulation of cytochrome P450 7A1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P22455

physically interacts with

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5936

English

17 August 2016

nintedanib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL502835

infigratinib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1852688

brivanib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL377300

erdafitinib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3545376

orantinib

1 reference

14 August 2023

https://platform.opentargets.org/drug/CHEMBL274654

has part(s)

tyrosine-protein kinase, active site

1 reference

protein kinase domain

1 reference

protein kinase, ATP binding site

1 reference

immunoglobulin subtype 2

1 reference

immunoglobulin I-set

1 reference

immunoglobulin-like domain

1 reference

tyrosine-protein kinase, catalytic domain

1 reference

immunoglobulin subtype

1 reference

serine-threonine/tyrosine-protein kinase, catalytic domain

1 reference

D08.811.913.696.620.682.725.400.180

Identifiers

MeSH descriptor ID

D051499

subject named as

Receptor, Fibroblast Growth Factor, Type 4

0 references

MeSH tree code

0 references

D12.776.543.750.630.443

0 references

D12.776.543.750.750.400.370.937

0 references

D12.776.476.568.400.180

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

Transporter Classification Database ID

English

8.A.23.1.9

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

1 reference

inferred by common MeSH mappings on source and on Wikidata

UMLS 2023