SMCR8-C9orf72 complex subunit (Q21135644)

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mammalian protein found in Homo sapiens

SMCR8
guanine nucleotide exchange protein SMCR8
Smith-Magenis syndrome chromosome region, candidate 8
smith-Magenis syndrome chromosomal region candidate gene 8 protein

Language	Label	Description	Also known as
English	SMCR8-C9orf72 complex subunit	mammalian protein found in Homo sapiens	SMCR8 guanine nucleotide exchange protein SMCR8 Smith-Magenis syndrome chromosome region, candidate 8 smith-Magenis syndrome chromosomal region candidate gene 8 protein

Statements

1 reference

13 November 2019

UniProt protein ID

1 reference

1 December 2016

UniProt protein ID

Folliculin/SMCR8, N-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Folliculin/SMCR8, tripartite DENN domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method or standard

5 references

8 April 2019

C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

8 April 2019

The C9orf72-interacting protein Smcr8 is a negative regulator of autoimmunity and lysosomal exocytosis

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

8 April 2019

Pooled-matrix protein interaction screens using Barcode Fusion Genetics

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

8 April 2019

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

protein kinase inhibitor activity

determination method or standard

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

protein kinase binding

determination method or standard

1 reference

8 April 2019

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

guanyl-nucleotide exchange factor activity

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

determination method or standard

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

guanyl-nucleotide exchange factor complex

determination method or standard

1 reference

8 April 2019

Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

Atg1/ULK1 kinase complex

determination method or standard

determination method or standard

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

8 April 2019

The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

biological process

negative regulation of protein kinase activity

determination method or standard

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

negative regulation of gene expression

determination method or standard

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

negative regulation of macroautophagy

determination method or standard

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

positive regulation of TOR signaling

determination method or standard

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

positive regulation of autophagosome maturation

determination method or standard

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

negative regulation of autophagosome assembly

determination method or standard

1 reference

8 April 2019

Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

regulation of TORC1 signaling

determination method or standard

1 reference

8 April 2019

C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

transcription, DNA-templated

determination method or standard

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TEV9&geneProductId=UniProtKB:Q8TEV9

determination method or standard

regulation of transcription, DNA-templated

determination method or standard

1 reference

5 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q8TEV9&geneProductId=UniProtKB:Q8TEV9

determination method or standard

determination method or standard

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q8TEV9

determination method or standard

Folliculin/SMCR8, N-terminal

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TEV9

Folliculin/SMCR8, tripartite DENN domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q8TEV9

Identifiers

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000492062

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000492062

ENSP00000385025

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000385025

Sitelinks

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Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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